Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chikako Setoguchi"'
Publikováno v:
Drug Metabolism and Disposition. 43:1956-1959
Systemically administered pravastatin effectively treats diabetic retinopathy without central nervous system side effects. The efflux transport mechanism of pravastatin from the brain has already been clarified. In this study, the influx of pravastat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cce7cbea6da9e66c5d0ef4bbfdf0b5a
https://doi.org/10.1124/dmd.115.066266
https://doi.org/10.1124/dmd.115.066266
Publikováno v:
Modern Rheumatology. 20:381-388
The combined effects of bucillamine (Buc) and etanercept (ETN) on a rat model of type II collagen (CII)-induced arthritis (CIA) after treatment onset were investigated. In the combination treatment, rats received Buc 30 mg/kg orally administered once
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd7a7d62103d1757d075974006554c1
https://doi.org/10.3109/s10165-010-0292-8
https://doi.org/10.3109/s10165-010-0292-8
Publikováno v:
Investigative ophthalmologyvisual science. 55(7)
PURPOSE The purpose of this study was to clarify the impact of P-glycoprotein (P-gp) on blood-retinal barrier (BRB) and blood-aqueous humor barrier (BAB) permeability, in contrast to blood-brain barrier (BBB) permeability. METHODS Permeabilities of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0d4f7db6608197f3b4182da8fcc962
https://pubmed.ncbi.nlm.nih.gov/24985475
https://pubmed.ncbi.nlm.nih.gov/24985475
Publikováno v:
International immunopharmacology. 14(1)
The improvement of rheumatoid factor titers in patients with rheumatoid arthritis is one of the significant clinical effects of bucillamine (Buc). In this study, we investigated the effects of SA981, an active metabolite of Buc, and methotrexate (MTX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceb34ebcb32613bbede595064f7c81a
https://pubmed.ncbi.nlm.nih.gov/22735757
https://pubmed.ncbi.nlm.nih.gov/22735757
Publikováno v:
International Journal of Immunopharmacology. 15:757-762
Thymulin is a well defined nonapeptide produced by thymic epithelial cells, and plays an important role in thymocyte differentiation. We investigated the restorative effect of thymulin on the stress-induced reduction in the production of antibodies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea2af5979ecc721d2f1db4939416151
https://doi.org/10.1016/0192-0561(93)90149-s
https://doi.org/10.1016/0192-0561(93)90149-s
Autor:
Chikako Setoguchi, Hiroyuki Inoue, Yoshimasa Sasabuchi, Ayako Sawa, Noriyoshi Yamamoto, Masahiro Okamoto, Hiroshi Suhara, Hiroshi Enomoto, Fumio Tsuji, Masakazu Ban, Masato Horiuchi
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(15)
A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-alpha production. We focused on the 1,1-substituted moiety (R(1) and R(2)) of SA13353 and investigated subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b434d9c0f7adff13d1ee329c304bf8
https://pubmed.ncbi.nlm.nih.gov/20580551
https://pubmed.ncbi.nlm.nih.gov/20580551
Autor:
Fumio Tsuji, Iwao Seki, Masafumi Nose, Masaaki Murai, Kenji Oki, Hiroshi Suhara, Chikako Setoguchi, Hiroyuki Aono, Minoru Sasano
Publikováno v:
European journal of pharmacology. 588(2-3)
Tumor necrosis factor-alpha (TNF-alpha) is known to play a crucial role in the pathogenesis of rheumatoid arthritis. In the present study, we demonstrate the effects of SA13353 (1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea), a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad2ced50e2784d0ad689848d62c08c7
https://pubmed.ncbi.nlm.nih.gov/18508045
https://pubmed.ncbi.nlm.nih.gov/18508045
Publikováno v:
Ensho. 17:87-89
Effects of salazosulfapyridine (SASP) and bucillamine (Bc), as disease-modifying antirheumatic drugs (DMARDs), on an active Arthus reaction and a delayed-type hypersensitivity (DTH) response were studied. SASP and Bc significantly suppressed the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3b14b4d4d49d4049d3c67b83a6ec7ac
https://doi.org/10.2492/jsir1981.17.87
https://doi.org/10.2492/jsir1981.17.87
Publikováno v:
Japanese Journal of Pharmacology. 58:120
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86ef0904ac8091f655ba32f0bc2070ef
https://doi.org/10.1016/s0021-5198(19)48860-4
https://doi.org/10.1016/s0021-5198(19)48860-4