Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chikako Nakai"'
Autor:
Chikako Nakai, Sachiyo Mimaki, Koutatsu Matsushima, Eiji Shinozaki, Kentaro Yamazaki, Kei Muro, Kensei Yamaguchi, Tomohiro Nishina, Satoshi Yuki, Kohei Shitara, Hideaki Bando, Yutaka Suzuki, Kiwamu Akagi, Shogo Nomura, Satoshi Fujii, Masaya Sugiyama, Nao Nishida, Masashi Mizokami, Yasuhiro Koh, Takuya Koshizaka, Hideki Okada, Yukiko Abe, Atsushi Ohtsu, Takayuki Yoshino, Katsuya Tsuchihara
Publikováno v:
International Journal of Clinical Oncology. 28:654-663
Background Oncogenic mutations in BRAF genes are found in approximately 5–10% of colorectal cancers. The majority of BRAF mutations are located within exons 11–15 of the catalytic kinase domains, with BRAF V600E accounting for more than 80% of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25534629028e92330b7a6f8f5355dee4
https://doi.org/10.1007/s10147-023-02318-w
https://doi.org/10.1007/s10147-023-02318-w
Autor:
Yukihito Ishizaka, Hitoshi Kurumizaka, Tetsutaro Sata, Yoshimasa Takizawa, Kenzo Tokunaga, Chikako Nakai-Murakami, Mari Shimura, Hiroaki Tachiwana
Recent observations imply that HIV-1 infection induces chromosomal DNA damage responses. However, the precise molecular mechanism and biological relevance are not fully understood. Here, we report that HIV-1 infection causes double-strand breaks in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87e7679ff69dbdadca9d071180babd8
https://doi.org/10.1158/0008-5472.c.6494105
https://doi.org/10.1158/0008-5472.c.6494105
Autor:
Yukihito Ishizaka, Hitoshi Kurumizaka, Tetsutaro Sata, Yoshimasa Takizawa, Kenzo Tokunaga, Chikako Nakai-Murakami, Mari Shimura, Hiroaki Tachiwana
Supplementary Method from HIV-1 Vpr Induces DNA Double-Strand Breaks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5ab8b4e565cc32226e7f5d7ee20518
https://doi.org/10.1158/0008-5472.22364255
https://doi.org/10.1158/0008-5472.22364255
Autor:
Satoshi Yuki, Masaya Sugiyama, Takeharu Yamanaka, Tomohiro Nishina, Kensei Yamaguchi, Satoshi Fujii, Hiroyasu Esumi, Atsushi Ohtsu, Kentaro Yamazaki, Sachiyo Mimaki, Eiji Shinozaki, Kohei Shitara, Kiwamu Akagi, Chikako Nakai, Koutatsu Matsushima, Kei Muro, Yutaka Suzuki, Katsuya Tsuchihara, Masashi Mizokami, Takayuki Yoshino, Shogo Nomura, Nao Nishida, Yasuhiro Koh, Yukiko Abe, Hideaki Bando
Publikováno v:
British Journal of Cancer
Background: Patients with BRAFV600E-mutated metastatic colorectal cancer (mCRC) have a poorer prognosis as well as resistance to anti-EGFR antibodies. However, it is unclear whether BRAF mutations other than BRAFV600E (BRAFnon-V600E mutations) contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c224f25ae0f61ede4d397ea63bdf8859
https://doi.org/10.1038/bjc.2017.308
https://doi.org/10.1038/bjc.2017.308
Autor:
Yukiko Abe, Takayuki Yoshino, Takeharu Yamanaka, Kentaro Yamazaki, Shogo Nomura, Yutaka Suzuki, Masaya Sugiyama, Hideaki Bando, Satoshi Yuki, Tomohiro Nishina, Katsuya Tsuchihara, Kohei Shitara, Eiji Shinozaki, Kiwamu Akagi, Nao Nishida, Sachiyo Mimaki, Yasuhiro Koh, Kensei Yamaguchi, Koutatsu Matsushima, Masashi Mizokami, Kei Muro, Hiroyasu Esumi, Atsushi Ohtsu, Satoshi Fujii, Chikako Nakai
To enable the widespread application of genomic medicine, the extraction of genomic DNA from thin sections of archived formalin-fixed and paraffin-embedded (FFPE) tissue blocks for next-generation sequencing (NGS) is often necessary. However, there a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a609215bd005a742850babc9809e185
https://europepmc.org/articles/PMC6759515/
https://europepmc.org/articles/PMC6759515/
Autor:
Shigeru Marubashi, Yukari Totsuka, Katsuya Tsuchihara, Sachiyo Mimaki, Masahiko Kinoshita, Hiroyasu Esumi, Hirofumi Arakawa, Shoji Kubo, Yutaka Suzuki, Tomonari Matsuda, Atsushi Ochiai, Tatsuhiro Shibata, Masanori Goto, Shigekazu Takemura, Shoji Nakamori, Chikako Nakai, Shogo Tanaka, Motohiro Kojima, Hitoshi Nakagama
Publikováno v:
Carcinogenesis
Summary These occupational cholangiocarcinoma cases shared a high mutation burden, strand bias and unique trinucleotide mutational signatures, suggesting that the patients might have been exposed to a common strong mutagen. The underlying mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33624718a85dfc5832f8f15e46435401
http://europepmc.org/articles/PMC4967217
http://europepmc.org/articles/PMC4967217
Publikováno v:
Journal of Pharmaceutical Sciences. 102:3196-3204
CYP3A4 and P-glycoprotein (P-gp) have similar substrate specificities and work together to form an intestinal absorption barrier against xenobiotics. Previous reports have indicated that CYP3A4 expression decreases gradually, whereas P-gp expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca6e4a026cc4595455abc0da0afb7c5
https://doi.org/10.1002/jps.23623
https://doi.org/10.1002/jps.23623
Autor:
Chikako Nakai-Murakami, Yukihito Ishizaka, Norio Yamamoto, Tetsutaro Sata, Kenzo Tokunaga, Takehiko Sasazuki, Shiori Haga, Yoshiaki Osawa, Naoki Yamamoto
Publikováno v:
Proceedings of the National Academy of Sciences
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a high-risk infectious pathogen. In the proposed model of respiratory failure, SARS-CoV down-regulates its receptor, angiotensin-converting enzyme 2 (ACE2), but the mechanism involved is unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a243ed9793a50c5472c46ca683503fc0
Publikováno v:
Experimental Cell Research. 313:3517-3525
Multidrug resistance-associated protein ABCC2 (MRP2) is widely expressed in mammalian tissues including intestine, liver and kidney, and it has been shown to be located exclusively on the apical membrane of polarized cells. Recently, several reports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c0c31bd52504d062fea7db3227e577
https://doi.org/10.1016/j.yexcr.2007.07.033
https://doi.org/10.1016/j.yexcr.2007.07.033
Publikováno v:
Current HIV research. 7(2)
We focus on the role of Vpr in inducing DNA double-strand breaks (DSBs) in the host cell. Based on the summarized findings of Vpr-induced DSBs and the finding of Vpr in the plasma of HIV-1-positive patients, we discuss the roles of Vpr in viral infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d09dd9b2174c07eca8503ed74a4dc4
https://pubmed.ncbi.nlm.nih.gov/19275579
https://pubmed.ncbi.nlm.nih.gov/19275579