Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Chika Takahashi-Kageyama"'
Autor:
Yoshiyuki Taoda, Toshiyuki Akiyama, Tomokazu Yoshinaga, Masayoshi Miyagawa, Kenji Tomita, Kenji Takaya, Kazunari Hattori, Shinya Shano, Takao Shishido, Akihiko Sato, Kazuya Yasuo, Makoto Kawai, Ryu Yoshida, Chika Takahashi-Kageyama
Publikováno v:
Journal of Medicinal Chemistry. 62:8101-8114
The medicinal chemistry and structure-activity relationships (SAR) for a novel series of carbamoyl pyridone bicycle (CAB) compounds as influenza Cap-dependent endonuclease (CEN) inhibitors are disclosed. Substituent effects were evaluated at the C (N
Autor:
Takao Shishido, Minako Mikamiyama-Iwata, Yoshiyuki Taoda, Tomokazu Yoshinaga, Ryu Yoshida, Naoko Kurihara, Naoyuki Suzuki, Kenji Morimoto, Noriyuki Kurose, Masayoshi Miyagawa, Hidenori Mikamiyama, Makoto Kawai, Kazunari Hattori, Kenji Tomita, Chika Takahashi-Kageyama, Toshiyuki Akiyama, Kenji Matsuo, Kenji Takaya, Akihiko Sato
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(19)
We report the discovery of a novel series of influenza Cap-dependent EndoNuclease (CEN) inhibitors based on the 4-pyridone-carboxylic acid (PYXA) scaffold, which were found from our chelate library. Our SAR research revealed the lipophilic domain to