Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Chika Sakai"'
Autor:
Noriyuki Naya, Chika Sakai, Daiki Okutsu, Ryo Kiguchi, Masakazu Fujiwara, Toshinaga Tsuji, Akira Iwanami
Publikováno v:
Neuropsychopharmacology Reports, Vol 41, Iss 1, Pp 26-39 (2021)
Abstract Aim Previously, we reported on the efficacy and safety of guanfacine extended‐release (GXR) in Japanese adults with attention‐deficit/hyperactivity disorder (ADHD) from a phase 3, double‐blind, placebo‐controlled, randomized trial. I
Externí odkaz:
https://doaj.org/article/1afcbb99cc3145e18b16b6c7120876a2
Autor:
Yukiko Miyazaki, Daniel K. Inaoka, Tomoo Shiba, Hiroyuki Saimoto, Takaya Sakura, Eri Amalia, Yasutoshi Kido, Chika Sakai, Mari Nakamura, Anthony L. Moore, Shigeharu Harada, Kiyoshi Kita
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to the respiratory chain by shuttling electrons to the ubiquinone pool. We have
Externí odkaz:
https://doaj.org/article/4343e700cc7f4f4caa097f95f6941062
Autor:
Ryo Kiguchi, Toshinaga Tsuji, Chika Sakai, Akira Iwanami, Masakazu Fujiwara, Noriyuki Naya, Daiki Okutsu
Publikováno v:
Neuropsychopharmacology Reports
Aim Previously, we reported on the efficacy and safety of guanfacine extended‐release (GXR) in Japanese adults with attention‐deficit/hyperactivity disorder (ADHD) from a phase 3, double‐blind, placebo‐controlled, randomized trial. In this ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382aff4d4edca34dab66b3113a9f8d3c
https://doi.org/10.1002/npr2.12152
https://doi.org/10.1002/npr2.12152
Autor:
Chika Sakai
Publikováno v:
Folia Pharmacologica Japonica. 155:413-425
Lisdexamfetamine dimesylate (hereinafter referred to as "lisdexamfetamine"; brand name, Vyvanse®), was developed for the treatment of attention-deficit/hyperactivity disorder (ADHD). This drug, which is classified as a central nervous system (CNS) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67d5ae8a8b2988e8e04dccfcf8bc4e9d
https://doi.org/10.1254/fpj.20033
https://doi.org/10.1254/fpj.20033
Autor:
Chika Sakai, Noriyuki Naya, Sungeun Jung, Toshinaga Tsuji, Yirong Chen, Nobuhiro Nishigaki, Hirotaka Kosaka
Publikováno v:
Cureus
Background Symptoms experienced by adult patients with attention-deficit/hyperactivity disorder (ADHD) frequently result in functional impairment across academic/occupational functioning, daily life, and social functioning. A substantial proportion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401c3626d6c74aa573cb5be4390431f7
https://doi.org/10.7759/cureus.19615
https://doi.org/10.7759/cureus.19615
Publikováno v:
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 30(8)
Purpose As the cancer survivors increase, patients using long-term and high-dose opioids are also increasing. Therefore, the promotion of appropriate use is important. This study investigated the actual status of opioid prescriptions in Japan and ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28856c5c72e51c8a4da65c227f918319
https://pubmed.ncbi.nlm.nih.gov/35543815
https://pubmed.ncbi.nlm.nih.gov/35543815
Autor:
Hisato Matsunaga, Hirokazu Mishima, Yuki Namba, Toru Nakai, Masakazu Fujiwara, Toshinaga Tsuji, Chika Sakai
Publikováno v:
Neuropsychiatric Disease and Treatment
Chika Sakai,1 Toshinaga Tsuji,1 Toru Nakai,1 Yuki Namba,1 Hirokazu Mishima,1 Masakazu Fujiwara,2 Hisato Matsunaga3 1Medical Affairs Department, Shionogi & Co. Ltd, Osaka, Japan; 2Data Science Office, Shionogi & Co. Ltd, Osaka, Japan; 3Department of N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a85e234089e2ca61f22318be957efa
https://pubmed.ncbi.nlm.nih.gov/34675521
https://pubmed.ncbi.nlm.nih.gov/34675521
Autor:
Akihiro, Tokunaga, Daisuke, Sugiyama, Yuka, Maeda, Allison Betof, Warner, Katherine S, Panageas, Sachiko, Ito, Yosuke, Togashi, Chika, Sakai, Jedd D, Wolchok, Hiroyoshi, Nishikawa
Publikováno v:
The Journal of Experimental Medicine
Corticosteroids inhibit antitumor immune responses of immune checkpoint blockade in a dose- and timing-dependent manner. Memory CD8+ T cells with low TCR affinity are selectively suppressed by corticosteroids, necessitating careful and thoughtful cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::355137cc7dc83ccd294d9f6069123292
https://pubmed.ncbi.nlm.nih.gov/31537643
https://pubmed.ncbi.nlm.nih.gov/31537643
Autor:
Takahiro Kinoshita, Chika Sakai, Yosuke Togashi, Masahito Kawazu, Masami Yamamoto, Eiichi Sato, Hiroyoshi Nishikawa, Toshihide Ueno, Akihito Kawazoe, Shogo Kumagai, Tetsuya Tsukamoto, Kohei Shitara, Hiroyuki Mano, Takeshi Kuwata, Sachiyo Nomura
Publikováno v:
Immunity. 53:187-203.e8
Only a small percentage of patients afflicted with gastric cancer (GC) respond to immune checkpoint blockade (ICB). To study the mechanisms underlying this resistance, we examined the immune landscape of GC. A subset of these tumors was characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6a5f76d2ce0fe37ae9f5bfca88024a
https://doi.org/10.1016/j.immuni.2020.06.016
https://doi.org/10.1016/j.immuni.2020.06.016
Autor:
Chika, Sakai, Hiroyoshi, Nishikawa
Publikováno v:
Gan to kagaku ryoho. Cancerchemotherapy. 45(2)
Tumor cells establish a unique circumstance called tumor microenvironment(TME)suitable for tumor development and progression. One ofthe most important advantages ofTME for tumor cells is immunosuppressive environment such as higher presence ofregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5c985e83654f8625dc2d2afc8c01826
https://pubmed.ncbi.nlm.nih.gov/29483409
https://pubmed.ncbi.nlm.nih.gov/29483409