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Oral Combination Vaccine, Comprising Bifidobacterium Displaying Hepatitis C Virus Nonstructural Protein 3 and Interferon-α, Induces Strong Cellular Immunity Specific to Nonstructural Protein 3 in Mice

Autor: Chika Omoto, Katsumi Shigemura, Koichi Kitagawa, Hiroki Saito, Hak Hotta, Tsugumi Oda, Toshiro Shirakawa, Takane Katayama, Ayame Araki

Publikováno v: Viral immunology. 30(3)

We previously generated an oral hepatitis C virus (HCV) vaccine using Bifidobacterium displaying the HCV nonstructural protein 3 (NS3) polypeptide. NS3-specific cellular immunity is important for viral clearance and recovery from HCV infection. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c02ae7685489584e9528d5ebcda84c
https://pubmed.ncbi.nlm.nih.gov/28112593

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Oral administration of genetically modified Bifidobacterium displaying HCV-NS3 multi-epitope fusion protein could induce an HCV-NS3-specific systemic immune response in mice

Autor: Katsumi Shigemura, Koichi Kitagawa, Masato Fujisawa, Masato Kawabata, Takane Katayama, Chika Omoto, Hak Hotta, Toshiro Shirakawa, Saki Takei, Naoya Morishita

Publikováno v: Vaccine. 32:3066-3074

More than 170 million people worldwide are chronic HCV (Hepatitis C virus) carriers, and about 30% of them will develop progressive liver disease, such as cirrhosis and hepatocellular carcinoma. A combination of pegylated interferon-α with ribavirin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45b54a07fbe215cda987eb9d933e5dd
https://doi.org/10.1016/j.vaccine.2014.03.022

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