Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Chijioke N Umunnakwe"'
1
Akademický článek
Evaluation of a commercial SARS-CoV-2 multiplex PCR genotyping assay for variant identification in resource-scarce settings.
Autor: Chijioke N Umunnakwe, Zinhle N Makatini, Mathapelo Maphanga, Anele Mdunyelwa, Khamusi M Mlambo, Puseletso Manyaka, Monique Nijhuis, Annemarie Wensing, Hugo A Tempelman
Publikováno v: PLoS ONE, Vol 17, Iss 6, p e0269071 (2022)
The rapid emergence and spread of numerous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants across the globe underscores the crucial need for continuous SARS-CoV-2 surveillance to ensure that potentially more pathogenic variants
Externí odkaz: https://doaj.org/article/daf96b25c1e34e7c8e9b57036ba77276
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2
Akademický článek
Defective proviruses significantly impact viral transcription and immune activation in men and women with HIV-1 subtype C in rural South Africa
Autor: Ninée V. E. J. Buchholtz, Lucas E. Hermans, Chijioke N. Umunnakwe, Marieke M. Nühn, Regina Voss, Emma Need, Neeltje A. Kootstra, Irma Maurer, Dorien C. M. de Jong, Jori Symons, Hugo A. Tempelman, Annemarie M. J. Wensing, Monique Nijhuis
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
IntroductionThe main obstacle to achieving an HIV-1 cure is the proviral reservoir. To promote equity in HIV cure strategies, it is crucial to study the viral reservoir of the predominant HIV-1 subtype C in both women and men. Therefore, we investiga
Externí odkaz: https://doaj.org/article/cb7079436e894078b14b9014db465d08
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4
Point-of-Care Tenofovir Urine Testing for the Prediction of Treatment Failure and Drug Resistance During Initial Treatment for Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Autor: Lucas E Hermans, Chijioke N Umunnakwe, Samanta T Lalla-Edward, Shane K Hebel, Hugo A Tempelman, Monique Nijhuis, Willem D F Venter, Annemarie M J Wensing
Publikováno v: Clinical Infectious Diseases. 76:e553-e560
Background Viral rebound during antiretroviral treatment (ART) is most often driven by suboptimal adherence in the absence of drug resistance. We assessed the diagnostic performance of point-of-care (POC) tenofovir (TFV) detection in urine for the pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58cae597712ebb1d150420f477b8510a
https://doi.org/10.1093/cid/ciac755
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5
Point-Of-Care Tenofovir urine Testing for the Prediction of Treatment Failure and Drug Resistance During Initial Treatment for HIV-1 Infection
Autor: Lucas E, Hermans, Chijioke N, Umunnakwe, Samanta T, Lalla-Edward, Shane K, Hebel, Hugo A, Tempelman, Monique, Nijhuis, Willem D F, Venter, Annemarie M J, Wensing
Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
Viral rebound during antiretroviral treatment (ART) is most often driven by suboptimal adherence in the absence of drug resistance. We assessed the diagnostic performance of point-of-care (POC) tenofovir (TFV) detection in urine for the prediction of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c1f284dc360e2d7fd3e44799e79e36c
https://pubmed.ncbi.nlm.nih.gov/36136811
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6
Evaluation of a commercial SARS-CoV-2 multiplex PCR genotyping assay for variant identification in resource-scarce settings
Autor: Chijioke N. Umunnakwe, Zinhle N. Makatini, Mathapelo Maphanga, Anele Mdunyelwa, Khamusi M. Mlambo, Puseletso Manyaka, Monique Nijhuis, Annemarie Wensing, Hugo A. Tempelman
Publikováno v: PloS one. 17(6)
The rapid emergence and spread of numerous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants across the globe underscores the crucial need for continuous SARS-CoV-2 surveillance to ensure that potentially more pathogenic variants
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d9a284b9225c3dcf23f9f753d9b327
https://pubmed.ncbi.nlm.nih.gov/35749403
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7
Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution
Autor: Jianbo Chen, Wei-Shau Hu, David Q. Sun, Olga A. Nikolaitchik, Ben Berkhout, Chijioke N. Umunnakwe, Atze T. Das, Vinay K. Pathak
Publikováno v: mBio, 11(6):e01578-20, 1-18. American Society for Microbiology
mBio, Vol 11, Iss 6 (2020)
mBio
The unspliced HIV-1 full-length RNA (HIV-1 RNA) is packaged into virions as the genome and is translated to generate viral structural proteins and enzymes. To serve these functions, HIV-1 RNA must be exported from the nucleus to the cytoplasm. It was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2ef47987a0c6e408a554c1b10a53e2
https://pure.amc.nl/en/publications/impact-of-nuclear-export-pathway-on-cytoplasmic-hiv1-rna-transport-mechanism-and-distribution(1e955778-abb2-4b59-bb62-7b01b95bb768).html
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8
Specific Guanosines in the HIV-2 Leader RNA are Essential for Efficient Viral Genome Packaging
Autor: Yang Liu, Wei-Shau Hu, Alice Duchon, Olga A. Nikolaitchik, Chijioke N. Umunnakwe, Jianbo Chen, Sheikh Abdul Rahman, Vinay K. Pathak, S.-H. Sheldon Tai
Publikováno v: J Mol Biol
HIV-2, a human pathogen that causes acquired immunodeficiency syndrome, is distinct from the more prevalent HIV-1 in several features including its evolutionary history and certain aspects of viral replication. Like other retroviruses, HIV-2 packages
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc41aa0ecf0fa7575e765b3f6959edb
https://pubmed.ncbi.nlm.nih.gov/33221337
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9
Identification of a homogenous structural basis for oligomerization by retroviral Rev-like proteins
Autor: Drena Dobbs, Susan Carpenter, Karin S. Dorman, Chijioke N. Umunnakwe
Publikováno v: Retrovirology
Background Rev-like proteins are post-transcriptional regulatory proteins found in several retrovirus genera, including lentiviruses, betaretroviruses, and deltaretroviruses. These essential proteins mediate the nuclear export of incompletely spliced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bdcb3dca2395745510d7c04f138218
https://pubmed.ncbi.nlm.nih.gov/28830558
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10
Computational modeling suggests dimerization of equine infectious anemia virus Rev is required for RNA binding
Autor: Jerald Rudy Chavez, Drena Dobbs, Chijioke N. Umunnakwe, Hyelee Loyd, Kinsey Cornick, Susan Carpenter
Publikováno v: Retrovirology
Background The lentiviral Rev protein mediates nuclear export of intron-containing viral RNAs that encode structural proteins or serve as the viral genome. Following translation, HIV-1 Rev localizes to the nucleus and binds its cognate sequence, term
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36ccb5d5a93031d1a37207572cedec1
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