Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Chihyuan Chuang"'
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Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy
Autor: Laura A. Robertson, Julia Schaletzky, Xiaolin Wang, Chihyuan Chuang, Yangsong Wu, James J. Hartman, Jingying Wang, Eddie Wehri, Eva R. Chin, Fady I. Malik, Scott Collibee, Mark Vander Wal, Jeanelle Zamora, Peadar Cremin, Morgan Bradley P, Luke W. Ashcraft, Darren T. Hwee, Wenyue Wang
Publikováno v: Journal of Medicinal Chemistry. 64:14142-14152
Hypercontractility of the cardiac sarcomere may be essential for the underlying pathological hypertrophy and fibrosis in genetic hypertrophic cardiomyopathies. Aficamten (CK-274) is a novel cardiac myosin inhibitor that was discovered from the optimi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57e158c743a4bf8ac97172694a8e35d
https://doi.org/10.1021/acs.jmedchem.1c01290
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4
Abstract 332: Pharmacologic Characterization of the Cardiac Myosin Inhibitor, CK-3773274: A Potential Therapeutic Approach for Hypertrophic Cardiomyopathy
Autor: James J. Hartman, Fady I. Malik, Julia Schaletzky, Kenneth Lee, Eva R Chin, Yangsong Wu, Bradley P Morgan, Eddie Wehri, Chihyuan Chuang, Darren T. Hwee, Khanha D. Taheri, Preeti Paliwal, Jingying Wang
Publikováno v: Circulation Research. 125
Hypercontractility of the cardiac sarcomere appears to underlie pathological hypertrophy and fibrosis in select genetic hypertrophic cardiomyopathies. Here, we characterize the small molecule, CK-3773274, as a novel cardiac myosin inhibitor that decr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aab40ad3254225a0aeb43ec40ea6e12a
https://doi.org/10.1161/res.125.suppl_1.332
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9
GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease
Autor: David R. Archer, Athiwat Hutchaleelaha, Mira Patel, Brian Metcalf, Larysa N. Patskovska, Chihyuan Chuang, Zhe Li, Qing Xu, Yury Patskovsky, Chengjing Zhou, Steven C. Almo, Donna Oksenberg, Abel Silva-Garcia, Uma Sinha, Kobina Dufu
Publikováno v: British journal of haematology. 175(1)
Summary A major driver of the pathophysiology of sickle cell disease (SCD) is polymerization of deoxygenated haemoglobin S (HbS), which leads to sickling and destruction of red blood cells (RBCs) and end-organ damage. Pharmacologically increasing the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3da859d0033d27cb65d4d24bab32e93
https://pubmed.ncbi.nlm.nih.gov/27410726
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