Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Chiho Koyama"'
Autor:
Akira Iizuka, Kiyohiko Takayama, Takashi Torashima, Miwako Yamasaki, Chiho Koyama, Kazuhiro Mitsumura, Masahiko Watanabe, Hirozaku Hirai
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 457-465 (2009)
Hotfoot5J mice are spontaneously occurring ataxic mice that lack δ2 glutamate receptor (GluRδ2) protein in cerebellar Purkinje cells. Here we aimed to rescue the ataxic phenotype of hotfoot5J mice by lentiviral vector-mediated expression of recombi
Externí odkaz:
https://doaj.org/article/8f7463c59f8547939e4609128399a39f
Autor:
Haruyasu Yamaguchi, Kiyohiko Takayama, Kazuhiro Mitsumura, Chiho Koyama, Hirokazu Hirai, Takashi Torashima, Akira Iizuka, Miho Oue, Shigeru Yanagi
Publikováno v:
EMBO reports. 9:393-399
Polyglutamine disorders are inherited neurodegenerative diseases caused by the accumulation of expanded polyglutamine protein (polyQ). Previously, we identified a new guanosine triphosphatase, CRAG, which facilitates the degradation of polyQ aggregat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc77f7a0dd0453e90f825250ce17bf3
https://doi.org/10.1038/embor.2008.31
https://doi.org/10.1038/embor.2008.31
Autor:
Anton N. Shuvaev, Akira Iizuka, Hirokazu Hirai, Go Kajiwara, Kiyohiko Takayama, Chiho Koyama, Yusuke Sawada
Publikováno v:
Cerebellum (London, England). 9(3)
Lentiviral vectors are promising as gene-transfer vehicles for gene therapy targeted to intractable brain diseases. Although lentiviral vectors are thought to exert little toxicity on infected cells, the adverse influence of viral infection on vulner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd504e05a4166a1654e20e60fcaf70fb
https://pubmed.ncbi.nlm.nih.gov/20178014
https://pubmed.ncbi.nlm.nih.gov/20178014
Autor:
Hajime Horiuchi, Masae Iino, Chiho Koyama, Masahiko Watanabe, Akira Iizuka, Takashi Torashima, Miwako Yamasaki, Kiyohiko Takayama, Kazuhiro Mitsumura, Hirozaku Hirai
Publikováno v:
The European journal of neuroscience. 30(3)
The delta2 glutamate receptor (GluRdelta2) is expressed predominantly in cerebellar Purkinje cells. GluRdelta2 knock-out mice show impaired synaptogenesis and loss of long-term depression (LTD) at parallel fiber/Purkinje cell synapses, and persistent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d1708e1fa1bfc522bfefce22501910
https://pubmed.ncbi.nlm.nih.gov/19614753
https://pubmed.ncbi.nlm.nih.gov/19614753
Autor:
Chiho Koyama, Hirozaku Hirai, Akira Iizuka, Masahiko Watanabe, Kazuhiro Mitsumura, Takashi Torashima, Kiyohiko Takayama, Miwako Yamasaki
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 457-465 (2009)
Hotfoot5J mice are spontaneously occurring ataxic mice that lack delta2 glutamate receptor (GluRdelta2) protein in cerebellar Purkinje cells. Here we aimed to rescue the ataxic phenotype of hotfoot5J mice by lentiviral vector-mediated expression of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cc9d842d52e7edfae0ac23f2ed28b6
https://pubmed.ncbi.nlm.nih.gov/19573599
https://pubmed.ncbi.nlm.nih.gov/19573599
Autor:
Takashi Torashima, Chiho Koyama, Nobuhiko Furuya, Hirokazu Hirai, Haruyasu Yamaguchi, Kazuhiro Mitsumura, Miho Oue
Publikováno v:
Brain research. 1255
We recently produced transgenic mice that expressed an abnormally expanded polyglutamine (polyQ) specifically in cerebellar Purkinje cells (polyQ mice). The polyQ mice showed inclusion body formation, cerebellar atrophy and severe ataxia. Here we ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c8bd95131979063880a5aae3358c72
https://pubmed.ncbi.nlm.nih.gov/19103174
https://pubmed.ncbi.nlm.nih.gov/19103174
Publikováno v:
Protocol Exchange.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e94efa4639096dddf22a1873a86cda14
https://doi.org/10.1038/nprot.2007.89
https://doi.org/10.1038/nprot.2007.89
Autor:
Hirokazu Hirai, Takashi Torashima, Chiho Koyama, Kazuhiro Mitsumura, Masae Iino, Akira Iizuka
Publikováno v:
Neuroscience Research. 65:S96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2ed0bb33623341fc051b20d8e114c00
https://doi.org/10.1016/j.neures.2009.09.406
https://doi.org/10.1016/j.neures.2009.09.406