Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Chihiro Tsukahara"'
Autor:
Ibuki Arizono, Naoki Fujita, Chihiro Tsukahara, Kana Sase, Reio Sekine, Tatsuya Jujo, Mizuki Otsubo, Naoto Tokuda, Yasushi Kitaoka
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 9, Pp 7097-7109 (2023)
Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has been studied to support human health against metabolic stress, cardiovascular disease, and neurodegenerative disease. In the present study, we investigated the e
Externí odkaz:
https://doaj.org/article/00457c21ff0c4bf1bc0b4cb1d03a95e6
Autor:
Masatoshi Mutazono, Misato Morita, Chihiro Tsukahara, Madoka Chinen, Shiori Nishioka, Tatsuhiro Yumikake, Kohei Dohke, Misuzu Sakamoto, Takashi Ideue, Jun-Ichi Nakayama, Kojiro Ishii, Tokio Tani
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006606 (2017)
In fission yeast, the formation of centromeric heterochromatin is induced through the RNA interference (RNAi)-mediated pathway. Some pre-mRNA splicing mutants (prp) exhibit defective formation of centromeric heterochromatin, suggesting that splicing
Externí odkaz:
https://doaj.org/article/44116123d34c466798f4d127e1e3a016
Publikováno v:
International Ophthalmology.
Purpose A relationship between p38 and autophagy remains debated. The aim of the current study is to investigate whether an inhibitor of p38 prevents axon loss induced by TNF and whether it affects autophagy. Methods Rats were given intravitreal inje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a53433ab12dcf7b8e0cee4ca006f738
https://doi.org/10.1007/s10792-023-02706-1
https://doi.org/10.1007/s10792-023-02706-1
Publikováno v:
Molecular Biology Reports
Excitotoxicity is involved in the retinal neuronal cell death in diabetic retinopathy. Although fenofibrate has been shown to ameliorate the progression of diabetic retinopathy, the effect of pemafibrate, which is highly selective for peroxisome prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e949b6f8abf4a4e3b878514e4a8c38b7
http://europepmc.org/articles/PMC7884588
http://europepmc.org/articles/PMC7884588
Publikováno v:
Molecular Biology Reports
Akebia Saponin D (ASD), a triterpenoid saponin, was shown to have protective effects in certain neuronal cells. The purpose of the present study was to investigate the possibility of ASD to prevent tumor necrosis factor (TNF)-induced axonal loss and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955dd99b6030d38fec66ea6066735907
https://doi.org/10.1007/s11033-020-06008-y
https://doi.org/10.1007/s11033-020-06008-y
Publikováno v:
Molecular Neurobiology
Nicotinamide adenine dinucleotide (NAD+) synthesis pathway has been involved in many biological functions. Nicotinamide riboside (NR) is widely used as an NAD+ precursor and known to increase NAD+ level in several tissues. The present study aimed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d824894251b1be93dc5aaf6c7c0f07e7
https://doi.org/10.1007/s12035-020-02063-5
https://doi.org/10.1007/s12035-020-02063-5
Autor:
Kana Sase, Chihiro Tsukahara, Yasushi Kitaoka, Naoto Tokuda, Hitoshi Takagi, Naoki Fujita, Jiro Kogo
Publikováno v:
Japanese Journal of Ophthalmology. 64:298-303
To examine the effects of SRT2104, an SIRT1 activator, in optic nerve degeneration induced by TNF and to investigate whether it affects the autophagic status after induction of axonal degeneration. Experimental. Adult male Wistar rats received intrav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f071ee002b5e4cc41c27aea104c8b957
https://doi.org/10.1007/s10384-020-00731-6
https://doi.org/10.1007/s10384-020-00731-6
Autor:
Yasushi Kitaoka, Kana Sase, Chihiro Tsukahara, Naoki Fujita, Ibuki Arizono, Jiro Kogo, Naoto Tokuda, Hitoshi Takagi
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Netarsudil, a Rho kinase inhibitor with norepinephrine transport inhibitory effect, lowers intraocular pressure, however, its effect on axon damage remains to be elucidated. The aim of the current study was to investigate the effect of netars
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453ca3362cf5259d35f8e9840039058f
https://pubmed.ncbi.nlm.nih.gov/34982146
https://pubmed.ncbi.nlm.nih.gov/34982146
Publikováno v:
Neurochemical Research
Tacrolimus, a calcineurin (CaN) inhibitor, has been used for treatment of refractory allergic ocular disease, although its role in optic nerve degeneration remains to be elucidated. In this study, we investigated whether tacrolimus modulates tumor ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c54481c97fb4485a86e2dda622e7cd3
https://pubmed.ncbi.nlm.nih.gov/31087207
https://pubmed.ncbi.nlm.nih.gov/31087207
Autor:
Tatsuhiro Yumikake, Kojiro Ishii, Madoka Chinen, Takashi Ideue, Misuzu Sakamoto, Kohei Dohke, Jun-ichi Nakayama, Misato Morita, Chihiro Tsukahara, Masatoshi Mutazono, Tokio Tani, Shiori Nishioka
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006606 (2017)
PLoS Genetics
PLoS Genetics
In fission yeast, the formation of centromeric heterochromatin is induced through the RNA interference (RNAi)-mediated pathway. Some pre-mRNA splicing mutants (prp) exhibit defective formation of centromeric heterochromatin, suggesting that splicing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7b153c6ca9af4ede18f5311810797d
http://europepmc.org/articles/PMC5322907?pdf=render
http://europepmc.org/articles/PMC5322907?pdf=render