Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Chihiro Iwaya"'
Autor:
Toshiyuki Itai, Fangfang Yan, Andi Liu, Yulin Dai, Chihiro Iwaya, Sarah W. Curtis, Elizabeth J. Leslie, Lukas M. Simon, Peilin Jia, Xiangning Chen, Junichi Iwata, Zhongming Zhao
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100313- (2024)
Summary: Orofacial clefts (OFCs) are common congenital birth defects with various etiologies, including genetic variants. Online Mendelian Inheritance in Man (OMIM) annotated several hundred genes involving OFCs. Furthermore, several hundreds of de n
Externí odkaz:
https://doaj.org/article/d1da2bc8f18746018552c2282332f15a
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract DHCR7 and SC5D are enzymes crucial for cholesterol biosynthesis, and mutations in their genes are associated with developmental disorders, which are characterized by craniofacial deformities. We have recently reported that a loss of either D
Externí odkaz:
https://doaj.org/article/a8de99937f974c849a8479e42a48e5ba
Autor:
Fangfang Yan, Akiko Suzuki, Chihiro Iwaya, Guangsheng Pei, Xian Chen, Hiroki Yoshioka, Meifang Yu, Lukas M. Simon, Junichi Iwata, Zhongming Zhao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Perturbations in gene regulation during palatogenesis can lead to cleft palate, which is among the most common congenital birth defects. Here, we perform single-cell multiome sequencing and profile chromatin accessibility and gene expression
Externí odkaz:
https://doaj.org/article/6cd15382d2174b2486bc7b4a4b70cba7
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract High-resolution computed tomography (CT) is widely used to assess bone structure under physiological and pathological conditions. Although the analytic protocols and parameters for micro-CT (μCT) analyses in mice are standardized for long b
Externí odkaz:
https://doaj.org/article/6793ab69420b45e2be981c041109b0d1
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3552 (2023)
Cleft lip and palate is one of the most common congenital birth defects and has a complex etiology. Either genetic or environmental factors, or both, are involved at various degrees, and the type and severity of clefts vary. One of the longstanding q
Externí odkaz:
https://doaj.org/article/107511b862174a2e9b24178ed73782ad
Publikováno v:
Human Genomics, Vol 11, Iss 1, Pp 1-8 (2017)
Abstract Background Epidemiological studies of DNA methylation profiles may uncover the molecular mechanisms through which genetic and environmental factors contribute to the risk of multifactorial diseases. There are two types of commonly used DNA b
Externí odkaz:
https://doaj.org/article/1925eb6d176f4d77bf11bd7ba3fbd10b
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 8992 (2020)
Carbohydrates, fats, and proteins are the underlying energy sources for animals and are catabolized through specific biochemical cascades involving numerous enzymes. The catabolites and metabolites in these metabolic pathways are crucial for many cel
Externí odkaz:
https://doaj.org/article/37d7bc6bb62e443d94b5de1efbb756d3
Autor:
Fangfang Yan, Akiko Suzuki, Chihiro Iwaya, Guangsheng Pei, Xian Chen, Hiroki Yoshioka, Meifang Yu, Lukas M. Simon, Junichi Iwata, Zhongming Zhao
SUMMARYThe abnormal perturbation in gene regulation during palatogenesis may lead to cleft palate, a major congenital birth defect in humans and mice. However, a comprehensive multi-omic map of the developing secondary palate at single-cell resolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3dcccb1c8970b32877aa5f5581a47ee
https://doi.org/10.1101/2022.11.02.514609
https://doi.org/10.1101/2022.11.02.514609
Publikováno v:
Development
The etiology of cleft lip with or without cleft palate (CL/P), a common congenital birth defect, is complex, with genetic and epigenetic, as well as environmental, contributing factors. Recent studies suggest that fetal development is affected by mat
Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren's syndrome-like exocrinopathy
Autor:
Akiko Suzuki, Chihiro Iwaya, Kenichi Ogata, Hiroki Yoshioka, Junbo Shim, Isei Tanida, Masaaki Komatsu, Norihiro Tada, Junichi Iwata
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(6)
Sjögren's syndrome (SjS) is a chronic autoimmune disease characterized by immune cell infiltration of the exocrine glands, mainly the salivary and lacrimal glands. Despite recent advances in the clinical and mechanistic characterization of the disea