Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Chihiro Tohda"'
Publikováno v:
Phytomedicine Plus, Vol 4, Iss 3, Pp 100613- (2024)
Introduction: In Alzheimer's disease (AD), neural circuit disconnection primarily causes memory dysfunction, which leads to the hypothesis that repairing neural networks may be an appropriate treatment strategy for AD. We previously found that diosge
Externí odkaz:
https://doaj.org/article/3d57ac9acae94095a56d4ea7a137b447
Autor:
Chihiro Tohda
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 5, Pp 1377-1389 (2025)
Spinal cord injury is an intractable traumatic injury. The most common hurdles faced during spinal cord injury are failure of axonal regrowth and reconnection to target sites. These also tend to be the most challenging issues in spinal cord injury. A
Externí odkaz:
https://doaj.org/article/a813180f719c4cbd8e70ca98aa030948
Autor:
Tsukasa Nagase, Chihiro Tohda
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 2199-2210 (2021)
Abstract Background Alzheimer's disease (AD) is an unmet medical need worldwide, and physical inactivity is a risk factor for AD. Performing physical exercise is difficult at old age, and thus, decline in physical movement may be a cause of age‐ass
Externí odkaz:
https://doaj.org/article/e29aca0d7a7c48e886b8459a2fff65c3
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/a21d245d6af046709c0315ce2d6d210a
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 11, Pp 1961-1967 (2019)
In chronic phase of spinal cord injury, functional recovery is more untreatable compared with early intervention in acute phase of spinal cord injury. In the last decade, several combination therapies successfully improved motor dysfunction in chroni
Externí odkaz:
https://doaj.org/article/ecd8f3c5d8da46f4a5524dab5a6c4a2e
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
We investigated the effects of a heptapeptide, GPPGPAG, on memory improvement and neuritic regeneration in Alzheimer’s disease models to evaluate its potency as a new anti-Alzheimer’s disease (AD) therapy. The anti-AD effects of GPPGPAG were eval
Externí odkaz:
https://doaj.org/article/d940fb0746d141afb4369045060657d9
Autor:
Toru Hosoi, Kyosuke Yazawa, Michihiro Imada, Akari Tawara, Chihiro Tohda, Yasuyuki Nomura, Koichiro Ozawa
Publikováno v:
Molecular Pharmacology. 103:266-273
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6878876250a0ec1d0deeb00575112e75
https://doi.org/10.1124/molpharm.121.000468
https://doi.org/10.1124/molpharm.121.000468
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Promoting axonal growth is essential for repairing damaged neuronal connections and motor function in spinal cord injury (SCI). Neuroleukin (NLK) exerts axonal growth activity in vitro and in vivo, but the mechanism remains unclear. This study reveal
Externí odkaz:
https://doaj.org/article/b4bb0ab739714f5c8665dc364713a259
Autor:
Chihiro Tohda, Ximeng Yang
Publikováno v:
Molecular Neurobiology. 60:1250-1266
Galectin-1 (Gal-1), a member of the Galectin family, is expressed in various tissues and responsible for multiple biological activities. Previous studies reported that extracellular Gal-1 participated in axonal growth and repair, and Gal-1 knockout m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8660f07bd5b79d3e5fd4e33f7b502d32
https://doi.org/10.1007/s12035-022-03125-6
https://doi.org/10.1007/s12035-022-03125-6
Autor:
Chihiro Tohda, Michihisa Tohda
Publikováno v:
BMC Research Notes, Vol 10, Iss 1, Pp 1-5 (2017)
Abstract Objective Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteases. Although commonly recognized as a lysosomal protease, cathepsin L is also secreted and involved
Externí odkaz:
https://doaj.org/article/58173c6358424efca497fe566bcffa0b