Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Chihiro, Okuma"'
Autor:
Katsuya Sakimura, Takashi Kawai, Reiko Nashida, Yuji Ishida, Kana Harada, Takashi Suzuki, Chihiro Okuma, Gregory M. Cole
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Alzheimer’s disease (AD) is the most common form of dementia. Although drugs focusing on reducing amyloid β slow progression, they fail to improve cognitive function. Deficits in glucose metabolism are reflected in FDG-PET and
Externí odkaz:
https://doaj.org/article/d0cd1b22ce1843a987fdf8ace4913d23
Autor:
Paul Denver, Heather D’Adamo, Shuxin Hu, Xiaohong Zuo, Cansheng Zhu, Chihiro Okuma, Peter Kim, Daniel Castro, Mychica R. Jones, Carmen Leal, Marisa Mekkittikul, Elham Ghadishah, Bruce Teter, Harry V. Vinters, Gregory Michael Cole, Sally A. Frautschy
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Alzheimer’s disease (AD) and mixed dementia (MxD) comprise the majority of dementia cases in the growing global aging population. MxD describes the coexistence of AD pathology with vascular pathology, including cerebral small vessel disease (SVD).
Externí odkaz:
https://doaj.org/article/d8dfc5a5a3ef4ae4be442906e4dd5013
Autor:
Daisuke Tomimoto, Chihiro Okuma, Yukihito Ishii, Akio Kobayashi, Takeshi Ohta, Makoto Kakutani, Tsuneo Imanaka, Nobuya Ogawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 1, Pp 51-58 (2015)
Type 2 diabetes mellitus (T2DM) arises primarily due to lifestyle factors and genetics. A number of lifestyle factors are known to be important in the development of T2DM, including obesity. JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase 1
Externí odkaz:
https://doaj.org/article/051859ed813e444b90d8d63ebc73c679
Autor:
Chihiro Okuma, Takeshi Ohta, Hironobu Tadaki, Tatsuya Ishigure, Shohei Sakata, Hideyuki Taniuchi, Ryuhei Sano, Hiromi Hamada, Shinichi Kume, Jun Nishiu, Makoto Kakutani
Publikováno v:
Journal of Pharmacological Sciences, Vol 128, Iss 3, Pp 150-157 (2015)
Aim: Monoacyglycerol acyltransferases (MGATs) are known to play important roles in intestinal TG absorption. In contrast, the role of MGATs in the liver is still unclear. We investigated the effects of JTP-103237, a novel MGAT inhibitor, on hepatic M
Externí odkaz:
https://doaj.org/article/4f84e16fc93843638e297033bf9858ca
Autor:
Chihiro Okuma, Takeshi Ohta, Makoto Ito, Hironobu Tadaki, Tomohiro Oda, Shinichi Kume, Jun Nishiu, Makoto Kakutani
Publikováno v:
Journal of Pharmacological Sciences, Vol 130, Iss 2, Pp 136-138 (2016)
Some nutrients, such as carbohydrate, fat and protein, are known to stimulate satiety. However, the effect of sn-2-monoacylglycerol (2-MG), one of the digestive products of triglycerides, on food intake is still unclear. In the present study, the eff
Externí odkaz:
https://doaj.org/article/75e71d1997c94870b15a717a96be6fdf
Autor:
Masaki, Inagaki, Yoshinori, Takizawa, Kenji, Uchiyama, Chikako, Yatsuka, Rie, Ichinohe, Junko, Tomita, Chihiro, Okuma, Kosuke, Haruki, Masaya, Tamano
Publikováno v:
Dokkyo Journal of Medical Sciences. 47(1):27-33
目的：腹部超音波検査にて，肝門部胆管の異常所見が胆膵疾患の拾い上げにどの程度寄与するか明らかにすることを目的として，肝門部胆管の超音波所見と最終診断について検討した．
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::f51d70e4ace3d7b98921aad40401267b
http://id.nii.ac.jp/1199/00002269/
http://id.nii.ac.jp/1199/00002269/
Autor:
Hiromi Yoshiuchi, Hironobu Tadaki, Chihiro Okuma, Reina Kakefuda, Takeshi Ohta, Yukihito Ishii, Daisuke Tomimoto, Mariko Maekawa, Ryuhei Sano, Yoshiaki Katsuda, Tomohiko Sasase
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1906-1912
Tumor necrosis factor-α (TNF-α) converting enzyme/a disintegrin and metalloproteinase domain-containing protein 17 (TACE/ADAM17) is a key sheddase that releases TNF-α from its inactive precursor and is thought as a new drug target to inhibit TNF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::483eb128e9f50cd62b7365039ba59613
https://doi.org/10.1248/bpb.b19-00526
https://doi.org/10.1248/bpb.b19-00526
Autor:
Mariko, Maekawa, Hironobu, Tadaki, Daisuke, Tomimoto, Chihiro, Okuma, Ryuhei, Sano, Yukihito, Ishii, Yoshiaki, Katsuda, Hiromi, Yoshiuchi, Reina, Kakefuda, Takeshi, Ohta, Tomohiko, Sasase
Publikováno v:
Biologicalpharmaceutical bulletin. 42(11)
Tumor necrosis factor-α (TNF-α) converting enzyme/a disintegrin and metalloproteinase domain-containing protein 17 (TACE/ADAM17) is a key sheddase that releases TNF-α from its inactive precursor and is thought as a new drug target to inhibit TNF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ddb819218037984ca0c3b9366095988
https://pubmed.ncbi.nlm.nih.gov/31685773
https://pubmed.ncbi.nlm.nih.gov/31685773
Autor:
Yukihito Ishii, Tsuneo Imanaka, Akio Kobayashi, Daisuke Tomimoto, Chihiro Okuma, Takeshi Ohta, Nobuya Ogawa, Makoto Kakutani
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 1, Pp 51-58 (2015)
Type 2 diabetes mellitus (T2DM) arises primarily due to lifestyle factors and genetics. A number of lifestyle factors are known to be important in the development of T2DM, including obesity. JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac6616f55bacc03c8b67f715e81877e
http://www.sciencedirect.com/science/article/pii/S1347861315001802
http://www.sciencedirect.com/science/article/pii/S1347861315001802
Autor:
Takeshi Ohta, Hideyuki Taniuchi, Tatsuya Ishigure, Jun Nishiu, Hiromi Hamada, Ryuhei Sano, Hironobu Tadaki, Chihiro Okuma, Shinichi Kume, Shohei Sakata, Makoto Kakutani
Publikováno v:
Journal of Pharmacological Sciences, Vol 128, Iss 3, Pp 150-157 (2015)
Aim Monoacyglycerol acyltransferases (MGATs) are known to play important roles in intestinal TG absorption. In contrast, the role of MGATs in the liver is still unclear. We investigated the effects of JTP-103237, a novel MGAT inhibitor, on hepatic MG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a761b08b0090e5a61333f3e2ee70290
https://doi.org/10.1016/j.jphs.2015.06.007
https://doi.org/10.1016/j.jphs.2015.06.007