Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chiharu Otani"'
Autor:
Shuhei Tsuji, Chiharu Otani, Takahiro Horie, Shin Watanabe, Osamu Baba, Naoya Sowa, Yuya Ide, Asami Kashiwa, Takeru Makiyama, Hirohiko Imai, Yasuhiro Nakashima, Tomohiro Yamasaki, Sijia Xu, Kazuki Matsushita, Keita Suzuki, Fuquan Zou, Eitaro Kume, Koji Hasegawa, Takeshi Kimura, Akira Kakizuka, Koh Ono
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 115850- (2024)
Aims: As heart failure (HF) progresses, ATP levels in myocardial cells decrease, and myocardial contractility also decreases. Inotropic drugs improve myocardial contractility but increase ATP consumption, leading to poor prognosis. Kyoto University S
Externí odkaz:
https://doaj.org/article/82e21e0f2691410394d8635d08158b4a
Autor:
Takahiro Horie, Tetsushi Nakao, Yui Miyasaka, Tomohiro Nishino, Shigenobu Matsumura, Fumiko Nakazeki, Yuya Ide, Masahiro Kimura, Shuhei Tsuji, Randolph Ruiz Rodriguez, Toshimitsu Watanabe, Tomohiro Yamasaki, Sijia Xu, Chiharu Otani, Sawa Miyagawa, Kazuki Matsushita, Naoya Sowa, Aoi Omori, Jin Tanaka, Chika Nishimura, Masataka Nishiga, Yasuhide Kuwabara, Osamu Baba, Shin Watanabe, Hitoo Nishi, Yasuhiro Nakashima, Marina R. Picciotto, Haruhisa Inoue, Dai Watanabe, Kazuhiro Nakamura, Tsutomu Sasaki, Takeshi Kimura, Koh Ono
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve t
Externí odkaz:
https://doaj.org/article/8523a0051c014923987d8a460a8d8a1f
Autor:
Yuya Ide, MD, Takahiro Horie, MD, PhD, Naritatsu Saito, MD, PhD, Shin Watanabe, MD, PhD, Chiharu Otani, MD, Yui Miyasaka, BSc, Yasuhide Kuwabara, MD, PhD, Tomohiro Nishino, MD, PhD, Tetsushi Nakao, MD, PhD, Masataka Nishiga, MD, PhD, Hitoo Nishi, MD, PhD, Yasuhiro Nakashima, MD, PhD, Fumiko Nakazeki, MD, PhD, Satoshi Koyama, MD, PhD, Masahiro Kimura, MD, Shuhei Tsuji, MD, Randolph Ruiz Rodriguez, MD, Sijia Xu, MD, Tomohiro Yamasaki, MD, Toshimitsu Watanabe, MD, Masamichi Yamamoto, PhD, Motoko Yanagita, MD, PhD, Takeshi Kimura, MD, PhD, Akira Kakizuka, MD, PhD, Koh Ono, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 701-714 (2019)
Summary: No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyo
Externí odkaz:
https://doaj.org/article/d66cbcb274f6484fb40460d224a0132a
Autor:
Satoshi Koyama, Takahiro Horie, Tomohiro Nishino, Osamu Baba, Naoya Sowa, Yui Miyasaka, Yasuhide Kuwabara, Tetsushi Nakao, Masataka Nishiga, Hitoo Nishi, Yasuhiro Nakashima, Fumiko Nakazeki, Yuya Ide, Masahiro Kimura, Shuhei Tsuji, Randolph Ruiz Rodriguez, Sijia Xu, Tomohiro Yamasaki, Chiharu Otani, Toshimitsu Watanabe, Tomoyuki Nakamura, Koji Hasegawa, Takeshi Kimura, Koh Ono
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 13 (2019)
Background MicroRNA (miR)‐33 targets cholesterol transporter ATP‐binding cassette protein A1 and other antiatherogenic targets and contributes to atherogenic progression. Its inhibition or deletion is known to result in the amelioration of athero
Externí odkaz:
https://doaj.org/article/69648184ded84dff81452fbc1f678cd7
Autor:
Sawa Miyagawa, Takahiro Horie, Tomohiro Nishino, Satoshi Koyama, Toshimitsu Watanabe, Osamu Baba, Tomohiro Yamasaki, Naoya Sowa, Chiharu Otani, Kazuki Matsushita, Hidenori Kojima, Masahiro Kimura, Yasuhiro Nakashima, Satoshi Obika, Yuuya Kasahara, Jun Kotera, Kozo Oka, Ryo Fujita, Takashi Sasaki, Akihiro Takemiya
Publikováno v:
Life Science Alliance; Aug2023, Vol. 6 Issue 8, p1-17, 17p
Autor:
Randolph Ruiz Rodriguez, Fumiko Nakazeki, Takeshi Kimura, Chiharu Otani, Yuya Ide, Sijia Xu, Takahiro Horie, Akira Kakizuka, Toshimitsu Watanabe, Koh Ono, Yui Miyasaka, Satoshi Koyama, Yasuhide Kuwabara, Naritatsu Saito, Masamichi Yamamoto, Tomohiro Nishino, Shin Watanabe, Yasuhiro Nakashima, Tomohiro Yamasaki, Masahiro Kimura, Hitoo Nishi, Motoko Yanagita, Masataka Nishiga, Shuhei Tsuji, Tetsushi Nakao
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 701-714 (2019)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • KUS121 was developed to selectively inhibit the adenosine triphosphatase activity of valosin-containing protein without affecting other cellular functions of valosin-containing protein. • KUS121 preserved adenosi
Highlights • KUS121 was developed to selectively inhibit the adenosine triphosphatase activity of valosin-containing protein without affecting other cellular functions of valosin-containing protein. • KUS121 preserved adenosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ca6171c32bb98e41fff95ae5384ca4
http://www.sciencedirect.com/science/article/pii/S2452302X19301822
http://www.sciencedirect.com/science/article/pii/S2452302X19301822
Autor:
Tomohiro Yamasaki, Toshimitsu Watanabe, Shigenobu Matsumura, Kazuhiro Nakamura, Chika Nishimura, Naoya Sowa, Takahiro Horie, Tomohiro Nishino, Yui Miyasaka, Sijia Xu, Masataka Nishiga, Randolph Ruiz Rodriguez, Yasuhide Kuwabara, Yasuhiro Nakashima, Chiharu Otani, Dai Watanabe, Haruhisa Inoue, Shin Watanabe, Yuya Ide, Tetsushi Nakao, Aoi Omori, Fumiko Nakazeki, Hitoo Nishi, Takeshi Kimura, Shuhei Tsuji, Osamu Baba, Jin Tanaka, Tsutomu Sasaki, Kazuki Matsushita, Sawa Miyagawa, Marina R. Picciotto, Masahiro Kimura, Koh Ono
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a564fc29dca384d57a72dc71fd711bfc
https://doi.org/10.1038/s41467-021-21107-5
https://doi.org/10.1038/s41467-021-21107-5
Autor:
Koh Ono, Toshimitsu Watanabe, Yuya Ide, Masahiro Kimura, Chiharu Otani, Takeshi Kimura, Tomohiro Yamasaki, Sijia Xu, Takahiro Horie, Randolph Ruiz Rodriguez, Osamu Baba, Shuhei Tsuji, Yasuhiro Nakashima, Yui Miyasaka
Publikováno v:
EMBO Reports
The Hippo signaling pathway is involved in the pathophysiology of various cardiovascular diseases. Yes‐associated protein (YAP) and transcriptional enhancer activator domain (TEAD) transcriptional factors, the main transcriptional complex of the Hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8873ea60e20059ee33252946d74525a2
https://doi.org/10.15252/embr.201948389
https://doi.org/10.15252/embr.201948389
Autor:
Koh Ono, Osamu Baba, Yuya Ide, Naoya Sowa, Masahiro Kimura, Tetsushi Nakao, Yasuhide Kuwabara, Satoshi Koyama, Randolph Ruiz Rodriguez, Yui Miyasaka, Tomohiro Nishino, Takahiro Horie, Tomohiro Yamasaki, Sijia Xu, Yasuhiro Nakashima, Hitoo Nishi, Chiharu Otani, Masataka Nishiga, Fumiko Nakazeki, Takeshi Kimura, Toshimitsu Watanabe, Shuhei Tsuji, Tomoyuki Nakamura, Koji Hasegawa
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Micro RNA (miR)‐33 targets cholesterol transporter ATP ‐binding cassette protein A1 and other antiatherogenic targets and contributes to atherogenic progression. Its inhibition or deletion is known to result in the amelioration of athe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282d6b1fced944bc8b59c92c5331250b
https://pubmed.ncbi.nlm.nih.gov/31242815
https://pubmed.ncbi.nlm.nih.gov/31242815