Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Chiharu Miyajima"'
Autor:
Mai Nagasaka, Yasumichi Inoue, Yuji Nagao, Chiharu Miyajima, Daisuke Morishita, Hiromasa Aoki, Mineyoshi Aoyama, Takeshi Imamura, Hidetoshi Hayashi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Transforming growth factor β (TGF-β) is a multifunctional cytokine that induces a diverse set of cellular processes principally through Smad-dependent transcription. Transcriptional responses induced by Smads are tightly regulated by Smad
Externí odkaz:
https://doaj.org/article/2ab13886656548118f875b0b10be51f9
Autor:
Muneshige Tokugawa, Yasumichi Inoue, Kan’ichiro Ishiuchi, Chisane Kujirai, Michiyo Matsuno, Masaki Ri, Yuka Itoh, Chiharu Miyajima, Daisuke Morishita, Nobumichi Ohoka, Shinsuke Iida, Hajime Mizukami, Toshiaki Makino, Hidetoshi Hayashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The unfolded protein response (UPR) controls protein homeostasis through transcriptional and translational regulation. However, dysregulated UPR signaling has been associated with the pathogenesis of many human diseases. Therefore, the compo
Externí odkaz:
https://doaj.org/article/f4d5583a2ef44886af048e669358049f
Autor:
Mai Nagasaka, Chiharu Miyajima, Hiromasa Aoki, Mineyoshi Aoyama, Daisuke Morishita, Yasumichi Inoue, Hidetoshi Hayashi
Publikováno v:
Cells, Vol 11, Iss 23, p 3825 (2022)
The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of target genes and diverse physiological processes. To precisely regulate the p53 network, p53 undergoes various post-translational modifications and alters t
Externí odkaz:
https://doaj.org/article/d8f6e75a10914b80b6059f190ae35569
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1015 (2022)
Transcriptional coactivator with PDZ-binding motif (TAZ) is a downstream transcriptional regulator of the Hippo pathway that controls cell growth and differentiation. The aberrant activation of TAZ correlates with a poor prognosis in human cancers, s
Externí odkaz:
https://doaj.org/article/bdbc09adf21e4582bda7aa1758804201
Autor:
Sakiko Nishikawa, Yasumichi Inoue, Yuka Hori, Chiharu Miyajima, Daisuke Morishita, Nobumichi Ohoka, Shigeaki Hida, Toshiaki Makino, Hidetoshi Hayashi
Publikováno v:
Antioxidants, Vol 9, Iss 9, p 842 (2020)
Kurarinone, a flavonoid isolated from the roots of Sophora flavescens, was suggested to exert potent antioxidant and immunosuppressive effects. However, the underlying mechanisms remain unclear. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a
Externí odkaz:
https://doaj.org/article/db34febb01324e019da29671db557636
Autor:
Chiharu Miyajima, Yuki Kawarada, Yasumichi Inoue, Chiaki Suzuki, Kana Mitamura, Daisuke Morishita, Nobumichi Ohoka, Takeshi Imamura, Hidetoshi Hayashi
Publikováno v:
Cells, Vol 9, Iss 1, p 171 (2020)
Transcriptional coactivator with a PDZ-binding motif (TAZ) is one of the mammalian orthologs of Drosophila Yorkie, a transcriptional coactivator of the Hippo pathway. TAZ has been suggested to function as a regulator that modulates the expression of
Externí odkaz:
https://doaj.org/article/fcef14e3b77d4bfca152e1dea35c0b3d
Autor:
Sakiko Nishikawa, Yuka Itoh, Muneshige Tokugawa, Yasumichi Inoue, Ken-ichi Nakashima, Yuka Hori, Chiharu Miyajima, Kou Yoshida, Daisuke Morishita, Nobumichi Ohoka, Makoto Inoue, Hajime Mizukami, Toshiaki Makino, Hidetoshi Hayashi
Publikováno v:
Molecules, Vol 24, Iss 17, p 3110 (2019)
In response to cellular stresses, activating transcriptional factor 4 (ATF4) regulates the expression of both stress-relieving genes and apoptosis-inducing genes, eliciting cell fate determination. Since pharmacological activation of ATF4 exerts pote
Externí odkaz:
https://doaj.org/article/77da10572a6043da8a2749f540681df9
Autor:
Mai Nagasaka, Yasumichi Inoue, Manaka Yoshida, Chiharu Miyajima, Daisuke Morishita, Muneshige Tokugawa, Haruna Nakamoto, Mayumi Sugano, Nobumichi Ohoka, Hidetoshi Hayashi
Publikováno v:
FEBS lettersReferences. 596(4)
The c-Myc oncoprotein is frequently overexpressed in human cancers and is essential for cancer cell proliferation. The dysregulation of ubiquitin-proteasome-mediated degradation is one of the contributing factors to the upregulated expression of c-My
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eea258ef3f9cdd890fa6fc69b22d432
https://pubmed.ncbi.nlm.nih.gov/35076962
https://pubmed.ncbi.nlm.nih.gov/35076962
Autor:
Nobumichi Ohoka, Muneshige Tokugawa, Hidetoshi Hayashi, Masayuki Komada, Yasumichi Inoue, Shin Watanabe, Daisuke Morishita, Chiharu Miyajima, Keishi Fukuura
Publikováno v:
J Biol Chem
Su(var)3–9, Enhancer-of-zeste, and Trithorax (SET) domain-containing protein 8 (SET8) is the sole enzyme that monomethylates Lys-20 of histone H4 (H4K20). SET8 has been implicated in the regulation of multiple biological processes, such as gene tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5215caa0554c13cf61ee1ea274772b
https://doi.org/10.1074/jbc.ra119.009006
https://doi.org/10.1074/jbc.ra119.009006
Autor:
Chiharu Miyajima, Daisuke Morishita, Yasumichi Inoue, Masaki Ri, Hajime Mizukami, Kan'ichiro Ishiuchi, Shinsuke Iida, Muneshige Tokugawa, Nobumichi Ohoka, Michiyo Matsuno, Hidetoshi Hayashi, Yuka Itoh, Toshiaki Makino, Chisane Kujirai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
The unfolded protein response (UPR) controls protein homeostasis through transcriptional and translational regulation. However, dysregulated UPR signaling has been associated with the pathogenesis of many human diseases. Therefore, the compounds modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b092e837b758421fd5b0ccb3ff5f48
https://doi.org/10.1038/s41598-021-89074-x
https://doi.org/10.1038/s41598-021-89074-x