Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Chiharu Hattori"'
Publikováno v:
Journal of Immunotoxicology, Vol 18, Iss 1, Pp 136-143 (2021)
Immunostimulatory effects of monoclonal antibodies (mAb) through binding to Fcγ receptors (FcγR) on immune cells are a likely cause of cytokine release syndrome. However, it is difficult to detect the potential risk of FcγR-dependent cytokine rele
Externí odkaz:
https://doaj.org/article/4fa8d7b3d9334334a65c40ee72fd091d
Autor:
Toshinori Agatsuma, George D. Demetri, Atsushi Ochiai, Toshihiko Doi, Suzanne George, Matthew L. Hemming, Sandro Santagata, Jessica L. Andersen, Taisei Nomura, Yuki Abe, Reiko Kamei, Koichiro Inaki, Takashi Nakada, Tsuyoshi Karibe, Takuma Iguchi, Jun Hasegawa, Manabu Abe, Chiharu Hattori, Michiko Kitamura, Satoru Yasuda, Tomoko Shibutani, Akiko Kawano Nagatsuma, Amr H. Abdelhamid Ahmed, Kenji Iida
Currently, the only approved treatments for gastrointestinal stromal tumor (GIST) are tyrosine kinase inhibitors (TKI), which eventually lead to the development of secondary resistance mutations in KIT or PDGFRA and disease progression. Herein, we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ff5c1a35e538f0f23815d732707bbe
https://doi.org/10.1158/2159-8290.c.6549451.v1
https://doi.org/10.1158/2159-8290.c.6549451.v1
Autor:
Toshinori Agatsuma, George D. Demetri, Atsushi Ochiai, Toshihiko Doi, Suzanne George, Matthew L. Hemming, Sandro Santagata, Jessica L. Andersen, Taisei Nomura, Yuki Abe, Reiko Kamei, Koichiro Inaki, Takashi Nakada, Tsuyoshi Karibe, Takuma Iguchi, Jun Hasegawa, Manabu Abe, Chiharu Hattori, Michiko Kitamura, Satoru Yasuda, Tomoko Shibutani, Akiko Kawano Nagatsuma, Amr H. Abdelhamid Ahmed, Kenji Iida
Characteristics for GIST patient samples, GPR20 expression in KIT/PDGFRA wild type GIST, GPR20 expression in normal, malignant and sarcoma tissue microarrays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27293cf28c63fa839c7af8be6d843fa1
https://doi.org/10.1158/2159-8290.22540666
https://doi.org/10.1158/2159-8290.22540666
Autor:
Toshinori Agatsuma, Yuki Abe, Takashi Nakada, Ichiro Hayakawa, Tetsuo Aida, Tomoko Shibutani, Yumi Nishiya, Akiko Watanabe, Kazuyoshi Kumagai, Chiharu Hattori, Takanori Maejima, Jun Hasegawa, Michiko Yamato
Supplementary Data from DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2555c866d4671115aaf3d352455d62eb
https://doi.org/10.1158/1535-7163.22521898.v1
https://doi.org/10.1158/1535-7163.22521898.v1
Autor:
Toshinori Agatsuma, Yuki Abe, Takashi Nakada, Ichiro Hayakawa, Tetsuo Aida, Tomoko Shibutani, Yumi Nishiya, Akiko Watanabe, Kazuyoshi Kumagai, Chiharu Hattori, Takanori Maejima, Jun Hasegawa, Michiko Yamato
B7-H3 is overexpressed in various solid tumors and has been considered as an attractive target for cancer therapy. Here, we report the development of DS-7300a, a novel B7-H3–targeting antibody–drug conjugate with a potent DNA topoisomerase I inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a31bd9f9c43f7e981e6be14ca30c4b1
https://doi.org/10.1158/1535-7163.c.6543217
https://doi.org/10.1158/1535-7163.c.6543217
Autor:
Toshinori Agatsuma, George D. Demetri, Atsushi Ochiai, Toshihiko Doi, Suzanne George, Matthew L. Hemming, Sandro Santagata, Jessica L. Andersen, Taisei Nomura, Yuki Abe, Reiko Kamei, Koichiro Inaki, Takashi Nakada, Tsuyoshi Karibe, Takuma Iguchi, Jun Hasegawa, Manabu Abe, Chiharu Hattori, Michiko Kitamura, Satoru Yasuda, Tomoko Shibutani, Akiko Kawano Nagatsuma, Amr H. Abdelhamid Ahmed, Kenji Iida
S1: Expression of GPR20 in clinical GIST specimens from NCCHE S2: Representative images of GPR20 expression in various sarcoma including GIST in University of Basel derived TMA. S3: GPR20 was not expressed in systemic mastocytosis. S4: Protein expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972e3baf460726f896fad4d66dcaea01
https://doi.org/10.1158/2159-8290.22540669
https://doi.org/10.1158/2159-8290.22540669
Autor:
Michiko Yamato, Jun Hasegawa, Takanori Maejima, Chiharu Hattori, Kazuyoshi Kumagai, Akiko Watanabe, Yumi Nishiya, Tomoko Shibutani, Tetsuo Aida, Ichiro Hayakawa, Takashi Nakada, Yuki Abe, Toshinori Agatsuma
Publikováno v:
Molecular Cancer Therapeutics. 21:635-646
B7-H3 is overexpressed in various solid tumors and has been considered as an attractive target for cancer therapy. Here, we report the development of DS-7300a, a novel B7-H3–targeting antibody–drug conjugate with a potent DNA topoisomerase I inhi
Autor:
Michiko Kitamura, Suzanne George, Sandro Santagata, Chiharu Hattori, Toshihiko Doi, Akiko Kawano Nagatsuma, Yuki Abe, Reiko Kamei, Tsuyoshi Karibe, Takuma Iguchi, Jun Hasegawa, Takashi Nakada, Matthew L. Hemming, Koichiro Inaki, Jessica L. Andersen, Amr H. Abdelhamid Ahmed, George D. Demetri, Tomoko Shibutani, Iida Kenji, Toshinori Agatsuma, Taisei Nomura, Satoru Yasuda, Manabu Abe, Atsushi Ochiai
Publikováno v:
Cancer Discovery. 11:1508-1523
Currently, the only approved treatments for gastrointestinal stromal tumor (GIST) are tyrosine kinase inhibitors (TKI), which eventually lead to the development of secondary resistance mutations in KIT or PDGFRA and disease progression. Herein, we id
Publikováno v:
Journal of Immunotoxicology, Vol 18, Iss 1, Pp 136-143 (2021)
Immunostimulatory effects of monoclonal antibodies (mAb) through binding to Fcγ receptors (FcγR) on immune cells are a likely cause of cytokine release syndrome. However, it is difficult to detect the potential risk of FcγR-dependent cytokine rele
Publikováno v:
Journal of immunotoxicology. 18(1)
Immunostimulatory effects of monoclonal antibodies (mAb) through binding to F