Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Chiharu Furukawa"'
Autor:
Akihiro Michihara, Hiroshi Matsuoka, Junichi Fujii, Chiharu Furukawa, Xianting Lin, Jianzhong Yang
Publikováno v:
Fundamental Toxicological Sciences; 2024, Vol. 11 Issue 5, p233-241, 9p
Autor:
Yun Jeong Jeong, Chiharu Furukawa, Young Chae Chang, Hiroo Nakajima, Shigefumi Kuwahara, Junji Magae
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 83:2244-2248
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays essential roles in human diseases including cancer. The synthetic ascochlorin derivative 4-O-methylascochlorin stabilizes HIF-1α protein, and activates its transcriptional activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29a2ecac4b9bb3a21cbd6dcab945debb
https://doi.org/10.1080/09168451.2019.1651626
https://doi.org/10.1080/09168451.2019.1651626
Publikováno v:
Radiation Research. 188:181-190
Biological response to ionizing radiation depends not only on the type of radiation and dose, but also on the duration and dose rate of treatment. For a given radiation dose, the biological response may differ based on duration and dose rate. We stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8821b1d8dd6dcde0c32b2c02e9b94eb
https://doi.org/10.1667/rr14666.1
https://doi.org/10.1667/rr14666.1
Publikováno v:
Gan to kagaku ryoho. Cancerchemotherapy. 46(3)
Compared to other types of breast cancers, triple-negative breast cancer(TNBC)has poor prognosis. However, much work has been done towards establishing an effective therapeutic strategy. Vinorelbine(VNB)is an effective therapeutic agent for TNBC, how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9c44cb524f40f60de08f7629d0c6994
https://pubmed.ncbi.nlm.nih.gov/30914582
https://pubmed.ncbi.nlm.nih.gov/30914582
Autor:
Keiko Taki, Kwan-Sik Min, Hiroo Nakajima, Kwang Kyun Park, Hyeun-Wook Chang, Chiharu Furukawa, Kensuke Otsuka, Young-Chae Chang, Junji Magae, Cheorl-Ho Kim, Kwan-Kyu Park, In-Seon Lee, Ji-Hak Jeong, Masanori Tomita
Publikováno v:
International Journal of Cancer. 124:2797-2803
Ascochlorin, a prenylphenol antitumor antibiotic, profoundly increases the expression of endogenous p53 by increasing protein stability in the human osteosarcoma cells and human colon cancer cells. Ascochlorin also increases DNA binding activity to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79de99eb8cc6ab667e77278ece31fd9c
https://doi.org/10.1002/ijc.24259
https://doi.org/10.1002/ijc.24259
Autor:
Junji Magae, Ikuya Fujiwara, Chiharu Furukawa, Young-Chae Chang, Naruhiko Mizuta, Mitsuhiko Mizuta, Hiroo Nakajima, Koichi Sakaguchi
Publikováno v:
The Journal of Antibiotics. 60:682-689
Estrogen receptor-negative breast cancers generally are highly malignant, resistant to chemotherapy and poorly prognostic. Here we demonstrate that estrogen receptor-negative human breast cancer cell lines highly express Fra-1, c-Fos and c-Jun, compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a257e9a818acd05f3264ec2ec15413c
https://doi.org/10.1038/ja.2007.87
https://doi.org/10.1038/ja.2007.87
Autor:
Mie Tsuruga, Chiharu Furukawa, Takashi Sugihara, Takaharu Nomura, Yurie Sasaki, Atsushi Ochiai, Junji Magae, Genichiro Ishii, Keiko Taki
Publikováno v:
Radiation Research. 167:592-599
Low-dose-rate radiation modulates various biological responses including carcinogenesis, immunological responses and diabetes. We found that continuous irradiation with low-dose-rate gamma rays ameliorated type II diabetes in db/db mice, diabetic mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492edaac4108372b2de490b6f166bd75
https://doi.org/10.1667/rr0786.1
https://doi.org/10.1667/rr0786.1
Autor:
Chiharu Furukawa, Junji Magae, Young-Chae Chang, Naruhiko Mizuta, Hisakazu Yamagishi, Koichi Sakaguchi, Hiroo Nakajima, Satoshi Ozawa, Kunio Ando
Publikováno v:
Biochemical and Biophysical Research Communications. 329:46-50
While agents targeting estrogen receptors are most effective in adjuvant therapy for human breast cancers expressing estrogen receptors after surgery, breast cancers lacking estrogen receptor are clinically serious, because they are highly malignant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07a8fdac264367dc5ae7c0fafe74db5
https://doi.org/10.1016/j.bbrc.2005.01.096
https://doi.org/10.1016/j.bbrc.2005.01.096
Publikováno v:
Radiation research. 176(4)
Irradiation time and dose rate are important factors in the evaluation of radiation risk for human health. We previously proposed a novel dose-rate effect model, the modified exponential (MOE) model, which predicts that radiation risks decline expone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38606a840099304d871b894ef6ff5c5
https://pubmed.ncbi.nlm.nih.gov/21943187
https://pubmed.ncbi.nlm.nih.gov/21943187
Autor:
Shuji Kojima, Hirohiko Shimizu, Chiharu Furukawa, Junji Magae, Mie Tsuruga, Ayako Maruyama, Kunio Ando
Publikováno v:
The Journal of antibiotics. 62(7)
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a crucial factor in the development of insulin resistance associated with type II diabetes. We previously found that 4-O-carboxymethyl ascochlorin, a derivative of ascochlorin, ameliora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1069237d987d36307c629ee8970cacd8
https://pubmed.ncbi.nlm.nih.gov/19557028
https://pubmed.ncbi.nlm.nih.gov/19557028