Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Chihae, Yang"'
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Externí odkaz:
https://doaj.org/article/0cdf25fd603e4227b58d1ab6f2e25867
Autor:
Monika Batke, Fatemeh Moradi Afrapoli, Rupert Kellner, James F. Rathman, Chihae Yang, Mark T. D. Cronin, Sylvia E. Escher
Publikováno v:
Frontiers in Toxicology, Vol 3 (2021)
The Threshold of Toxicological Concern (TTC) concept can be applied to organic compounds with the known chemical structure to derive a threshold for exposure, below which a toxic effect on human health by the compound is not expected. The TTC concept
Externí odkaz:
https://doaj.org/article/94a1725ac32c45b78c0406d6254c6e57
Autor:
Ann M. Richard, Ryan Lougee, Matthew Adams, Hannah Hidle, Chihae Yang, James Rathman, Tomasz Magdziarz, Bruno Bienfait, Antony J. Williams, Grace Patlewicz
Publikováno v:
Chemical Research in Toxicology. 36:508-534
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3e2eee2e2a73aef0d31269ed0fd5ead
https://doi.org/10.1021/acs.chemrestox.2c00403
https://doi.org/10.1021/acs.chemrestox.2c00403
Autor:
Emilio Benfenati, Alessandra Roncaglioni, Edoardo Carnesecchi, Matilda Mazzucotelli, Marco Marzo, Andrey Toropov, Alla Toropova, Rossella Baldin, Andrea Ciacci, Simona Kovarich, Luca Sartori, Chihae Yang, Tomasz Magdziarz, Bryan Hobocienski, Aleksandra Mostrag
Publikováno v:
EFSA Supporting Publications. 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68924fb46324b52aa6965ccda72b37b1
https://doi.org/10.2903/sp.efsa.2022.en-7635
https://doi.org/10.2903/sp.efsa.2022.en-7635
Autor:
Chihae Yang, James F Rathman, Bruno Bienfait, Matthew Burbank, Ann Detroyer, Steven J. Enoch, James W. Firman, Steve Gutsell, Nicola J. Hewitt, Bryan Hobocienski, Gerry Kenna, Judith C. Madden, Tomasz Magdziarz, Jörg Marusczyk, Aleksandra Mostrag-Szlichtyng, Christopher-Tilman Krueger, Cathy Lester, Catherine Mahoney, Abdulkarim Najjar, Gladys Ouedraogo, Katarzyna R. Przybylak, J. Vinicius Ribeiro, Mark T.D. Cronin
Publikováno v:
Computational Toxicology. 26:100272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5741cc1baeed6bd50fa239de98753095
https://doi.org/10.1016/j.comtox.2023.100272
https://doi.org/10.1016/j.comtox.2023.100272
Autor:
Chihae Yang, James F. Rathman, Cynthia B. Pestana, James W. Firman, Mark T. D. Cronin, Mathieu Vinken
Publikováno v:
Chemical Research in Toxicology. 34:641-655
Owing to the primary role which it holds within metabolism of xenobiotics, the liver stands at heightened risk of exposure to, and injury from, potentially hazardous substances. A principal manifestation of liver dysfunction is cholestasis-the impair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef7797ce573997271e1e9ba05acff35
https://doi.org/10.1021/acs.chemrestox.0c00465
https://doi.org/10.1021/acs.chemrestox.0c00465
Autor:
Sylvia E, Escher, Susan P, Felter, Heli, Hollnagel, Alan R, Boobis, Chihae, Yang, James, Rathman, Mark T D, Cronin, Monika, Batke
Publikováno v:
ALTEX.
Threshold of toxicological concern (TTC) values are frequently used for compounds occurring at low concentrations in feed and food or as impurities in drugs. This workshop report addresses the emerging alternatives for deriving TTC values for DNA rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8dcf779bbc7d2e82056afe344bbedd
https://doi.org/10.14573/altex.2210111
https://doi.org/10.14573/altex.2210111
Publikováno v:
Computational Toxicology (Amsterdam, Netherlands)
In silico chemical safety assessment potentially allows for the evaluation of hazard and risk following potential exposure to a substance. A Symposium identified a number of opportunities and challenges to implement in silico methods, such as quantit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8dd6b29c5c916783ed5d9e98ae5297
https://doi.org/10.1016/j.comtox.2018.12.006
https://doi.org/10.1016/j.comtox.2018.12.006
Autor:
B. Montemayor, R. Taalman, Rajeshwar P. Verma, Hajime Kojima, J. Field, Matt Dent, Vera Rogiers, C. Willett, Janine Ezendam, João Barroso, Gladys Ouedraogo, M. Lorencini, Chihae Yang, Tara S. Barton-Maclaren, Susanne Hougaard Bennekou, Paul L. Carmichael, E. Vaillancourt, Suzanne Fitzpatrick, Reinhard Kreiling, J. Ansell, R. Mazaro-Costa, J. Oliveira, Russell S. Thomas, Kim Boekelheide, D. Smegal, Catherine Mahony, Y. Tokura, M. Hatao
Publikováno v:
Dent, M P, Vaillancourt, E, Thomas, R S, Carmichael, P L, Ouedraogo, G, Kojima, H, Barroso, J, Ansell, J, Barton-Maclaren, T S, Bennekou, S H, Boekelheide, K, Ezendam, J, Field, J, Fitzpatrick, S, Hatao, M, Kreiling, R, Lorencini, M, Mahony, C, Montemayor, B, Mazaro-Costa, R, Oliveira, J, Rogiers, V, Smegal, D, Taalman, R, Tokura, Y, Verma, R, Willett, C & Yang, C 2021, ' Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients ', Regulatory Toxicology and Pharmacology, vol. 125, 105026 . https://doi.org/10.1016/j.yrtph.2021.105026
Next generation risk assessment (NGRA) is an exposure-led, hypothesis-driven approach that has the potential to support animal-free safety decision-making. However, significant effort is needed to develop and test the in vitro and in silico (computat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9c756a1ebd0b3e0cf3dcb968552455
https://pubmed.ncbi.nlm.nih.gov/34389358
https://pubmed.ncbi.nlm.nih.gov/34389358
Autor:
Richard, Ann, Lougee, Ryan, Patlewicz, Grace, Grulke, Christopher, Williams, Antony, Chihae Yang, Rathman, James, Magdziarz, Tomasz
Presentation to the Society of Toxicology annual meeting March 2021, March 12-26, 2021
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c3248824756676a40bcc991b42adb0
