Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis.

Autor: Li Qin, Fei Da, Emilie L Fisher, Daniel C S Tan, Thuan H Nguyen, Chih-Lung Fu, Vee Y Tan, Joshua W McCausland, Daniel E Sturdevant, Hwang-Soo Joo, Shu Y Queck, Gordon Y C Cheung, Michael Otto

Publikováno v: PLoS Pathogens, Vol 13, Iss 2, p e1006153 (2017)

Bacterial sepsis is a major killer in hospitalized patients. Coagulase-negative staphylococci (CNS) with the leading species Staphylococcus epidermidis are the most frequent causes of nosocomial sepsis, with most infectious isolates being methicillin

Externí odkaz: https://doaj.org/article/0232038b1b1e4dd497951e084a965e80

A Small Membrane Stabilizing Protein Critical to the Pathogenicity of Staphylococcus aureus

Autor: Alaa Abdulaziz Alnahari, Ruth C. Massey, Maisem Laabei, Kate J. Heesom, Michael Otto, Rachel M. McLoughlin, Chih-Lung Fu, Eric P. Skaar, Seána Duggan, Eóin C O'Brien, Keenan A. Lacey, Leann Bacon

Publikováno v: Duggan, S, Laabei, M, Alnahari, A, O'Brien, E T, Lacey, K, Bacon, L, Heesom, K J, Fu, C-L, Otto, M, Skaar, E, McLoughlin, R M & Massey, R C 2020, ' A small membrane stabilising protein critical to the pathogenicity of Staphylococcus aureus ', Infection and Immunity . https://doi.org/10.1128/IAI.00162-20
Infection and Immunity

Staphylococcus aureus is a major human pathogen, and the emergence of antibiotic-resistant strains is making all types of S. aureus infections more challenging to treat. With a pressing need to develop alternative control strategies to use alongside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bea0afb3aada33cb3a7ec1cae5ce2c
https://doi.org/10.1128/iai.00162-20

Staphylococcus aureus Phenol-Soluble Modulins Impair Interleukin Expression in Bovine Mammary Epithelial Cells

Autor: Ksenia Semenovskaya, Pierre Germon, Martine Deplanche, Yves Le Loir, Chih-Lung Fu, Frederic Dessauge, Liudmila Alekseeva, Pascal Rainard, David Ge Smith, Laurence Finot, Nadejda Berkova, Holm Zerbe, Michael Otto, Wolfram Petzl

Publikováno v: Infection and Immunity
Infection and Immunity, American Society for Microbiology, 2016, 84 (6), pp.1682-1692. ⟨10.1128/IAI.01330-15⟩
Journées d'Animation Scientifique du Département Santé Animale
Journées d'Animation Scientifique du Département Santé Animale, May 2016, Chasseneuil-du-Poitou France. 98 p., 2016
Journées d'Animation Scientifique du Département Santé Animale, May 2016, Chasseneuil-du-Poitou, France. 98 p., 2016

The role of the recently described interleukin-32 (IL-32) in Staphylococcus aureus -induced mastitis, an inflammation of the mammary gland, is unclear. We determined expression of IL-32, IL-6, and IL-8 in S. aureus - and Escherichia coli -infected bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1255fbe80c9ffd646ef65fbe6ded4a5
https://doi.org/10.1128/iai.01330-15

Virulence determinants associated with the Asian community-associated methicillin-resistant Staphylococcus aureus lineage ST59

Autor: Min Li, Yuanjun Zhu, Vee Y. Tan, Yingxin Dai, Juanxiu Qin, Chih-Lung Fu, Xing Wang, Xiaowei Ma, Jing-Yuan Fang, Tianming Li, Xufen Hong, Qian Liu, Yanan Wang, Michael Otto

Publikováno v: Scientific Reports

Understanding virulence is vital for the development of novel therapeutics to target infections with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), which cause an ongoing epidemic in the United States and are on a global

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd642cc3d0d002c165393a49e75fa11
http://europepmc.org/articles/PMC4906288

Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S

Autor: Kwame Tuffuor, Anthony J. Yeh, Hwang-Soo Joo, Dorothee Kretschmer, Andreas Peschel, Binh An Diep, Yuumi Nakamura, Gabriel Núñez, Gordon Y. C. Cheung, Anthony C. Duong, Min Li, Michael Otto, Chih Lung Fu

Publikováno v: Scientific Reports

Staphylococcus aureus δ-toxin is a member of the phenol-soluble modulin (PSM) peptide family. PSMs have multiple functions in staphylococcal pathogenesis; for example, they lyse red and white blood cells and trigger inflammatory responses. Compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85812d31af7a5073e9c7d9c2ba89d71
https://doi.org/10.1038/srep18023