Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Chih-Lin Hsieh"'
Autor:
Zarko Manojlovic, Jordan Wlodarczyk, Cindy Okitsu, Yuxin Jin, David Van Den Berg, Michael R. Lieber, Chih-Lin Hsieh
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-6 (2023)
Abstract Objective Comprehensive and reliable genome-wide variant analysis of a small number of cells has been challenging due to genome coverage bias, PCR over-cycling, and the requirement of expensive technologies. To comprehensively identify genom
Externí odkaz:
https://doaj.org/article/4260e4607375442b84e92339103a96e2
Autor:
Heather A. Ogana, Samantha Hurwitz, Chih-Lin Hsieh, Huimin Geng, Markus Müschen, Deepa Bhojwani, Mark A. Wolf, James Larocque, Michael R. Lieber, Yong Mi Kim
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
As effective therapies for relapse and refractory B-cell acute lymphoblastic leukemia (B-ALL) remain problematic, novel therapeutic strategies are needed. Artemis is a key endonuclease in V(D)J recombination and nonhomologous end joining (NHEJ) of DN
Externí odkaz:
https://doaj.org/article/16124452d48a4bd1a4732545972846eb
Autor:
Yongsheng Ruan, Hye Na Kim, Heather A. Ogana, Zesheng Wan, Samantha Hurwitz, Cydney Nichols, Nour Abdel-Azim, Ariana Coba, Seyoung Seo, Yong-Hwee Eddie Loh, Eun Ji Gang, Hisham Abdel-Azim, Chih-Lin Hsieh, Michael R. Lieber, Chintan Parekh, Dhananjaya Pal, Deepa Bhojwani, Donald L. Durden, Yong-Mi Kim
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The PI3K/Akt pathway—and in particular PI3Kδ—is known for its role in drug resistant B-cell acute lymphoblastic leukemia (B-ALL) and it is often upregulated in refractory or relapsed B-ALL. Myc proteins are transcription factors responsible for
Externí odkaz:
https://doaj.org/article/9d2a16f695cc4722b8574521dd391e56
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109387- (2021)
Summary: Analysis of translocation breakpoints in human B cell malignancies reveals that DNA double-strand breaks at oncogenes most frequently occur at CpG sites located within 20–600 bp fragile zones and depend on activation-induced deaminase (AID
Externí odkaz:
https://doaj.org/article/36bc2879a10947e3906294f6c965ccfa
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 557-569 (2014)
R loops exist at the murine IgH switch regions and possibly other locations, but their functional importance is unclear. In biochemical systems, R loop initiation requires DNA sequence regions containing clusters of G nucleotides, but cellular studie
Externí odkaz:
https://doaj.org/article/8325885ccd534711aaa18a134a04e9b2
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 316-320 (2014)
Summary: Of the three DNA ligases present in all vertebrates, DNA ligase I (Lig1) has been considered essential for ligating Okazaki fragments during DNA replication and thereby essential for cell viability. Here, we report the striking finding that
Externí odkaz:
https://doaj.org/article/bbb6d8054d6a46fa962fce08ac01c879
Autor:
Chih-Lin Hsieh, 謝芷霖
103
The purpose of the study was to understand the nutrition and oral candidiasis cases of people in Taiwan Hansen hospital. Combining with previous oral health information data, the study hoped to find potential issues for the nutrition statues
The purpose of the study was to understand the nutrition and oral candidiasis cases of people in Taiwan Hansen hospital. Combining with previous oral health information data, the study hoped to find potential issues for the nutrition statues
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/71910025183119611073
Autor:
Chih-Lin Hsieh, 謝志琳
100
Due to the limitation of fossil fuel resources, oil prices have being gradually increasing. Besides, combustion of fossil fuels will increase carbon dioxide in the atmosphere, resulting in the greenhouse effect. Therefore, it has become an u
Due to the limitation of fossil fuel resources, oil prices have being gradually increasing. Besides, combustion of fossil fuels will increase carbon dioxide in the atmosphere, resulting in the greenhouse effect. Therefore, it has become an u
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/31039388297643340135
Autor:
Jianfeng Xu, William J. Catalona, Graham G. Giles, Brian T. Helfand, Michael J. Ackerman, Janet L. Stanford, Rosalind A. Eeles, O. Cussenot, Christopher J. Klein, Melissa C. Larson, Daniel J. Schaid, Zachary C. Fogarty, Lisa A. Cannon Albright, Cheryl D. Cropp, John D. Carpten, Shannon K. McDonnell, F. Wiklund, Zsofia Kote-Jarai, Robert J. MacInnis, Tu Nguyen-Dumont, Diptasri Mandal, Joan E. Bailey-Wilson, William B. Isaacs, Shaun M. Riska, Chih-Lin Hsieh, Josef Hoegel, Elaine A. Ostrander, Liesel M. FitzGerald, Alice S. Whittemore, Lissa DeRycke, Kathleen A. Cooney, Geraldine Cancel-Tassin, Craig C. Teerlink, Nilah Monnier Ioannidis, Saurabh Bahetti, Johanna Schleutker, Melissa C. Southey, Weiva Sieh, Stephen N. Thibodeau
Publikováno v:
European Urology. 79:353-361
Background Family history of prostate cancer (PCa) is a well-known risk factor, and both common and rare genetic variants are associated with the disease. Objective To detect new genetic variants associated with PCa, capitalizing on the role of famil
Publikováno v:
Mol Immunol
Spontaneous DNA-PKcs deficiencies in animals result in a severe combined immunodeficiency (SCID) phenotype because DNA-PKcs is required to activate Artemis for V(D)J recombination coding end hairpin opening. The impact on signal joint formation in th