Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Chih-Liang Tien"'
Autor:
Xiaokang Luo, Shiyang Song, Lei Qi, Chih-Liang Tien, Hui Li, Weiyi Xu, Theodore Lemuel Mathuram, Thomas Burris, Yuanbiao Zhao, Zheng Sun, Lilei Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
REV-ERB agonists have shown antifibrotic effects in the heart and other organs. The function of REV-ERB in the cardiac fibroblasts remains unstudied. Here, we characterize the functional difference of REV-ERB in mouse embryonic fibroblasts and cardia
Externí odkaz:
https://doaj.org/article/f968753e53384be3aaed3518750afe84
Autor:
Hui Li, Shiyang Song, Chih-liang Tien, Lei Qi, Andrea Graves, Eleni Nasiotis, Thomas P. Burris, Yuanbiao Zhao, Zheng Sun, Lilei Zhang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
The core clock component REV-ERB is essential for heart function. Previous studies show that REV-ERB agonist SR9009 ameliorates heart remodeling in the pressure overload model with transverse aortic constriction (TAC). However, it is unknown whether
Externí odkaz:
https://doaj.org/article/8991e186795141b6a3354c14b196d528
Autor:
Chih-Liang Tien, 田至良
94
Spinocerebellar ataxias are neurological disorders, and many subtypes were identified. Machado-Joseph disease (MJD) / SCA3 is the most common type. This disease is caused by CAG trinucleotide repeat expansion and the abnormal CAG repeats are
Spinocerebellar ataxias are neurological disorders, and many subtypes were identified. Machado-Joseph disease (MJD) / SCA3 is the most common type. This disease is caused by CAG trinucleotide repeat expansion and the abnormal CAG repeats are
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/83151689229935244125
Autor:
Shiyang Song, Chih-Liang Tien, Hao Cui, Paul Basil, Ningxia Zhu, Yingyun Gong, Wenbo Li, Hui Li, Qiying Fan, Jong Min Choi, Weijia Luo, Yanfeng Xue, Rui Cao, Wenjun Zhou, Andrea R. Ortiz, Brittany Stork, Vatsala Mundra, Nagireddy Putluri, Brian York, Maoping Chu, Jiang Chang, Sung Yun Jung, Liang Xie, Jiangping Song, Lilei Zhang, Zheng Sun
Publikováno v:
Circulation. 145:448-464
Background: The nuclear receptor Rev-erbα/β, a key component of the circadian clock, emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not been studied in vivo. Circadian disruption is implicated in heart diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50457f9344d2a36e4c6b4d6a8dc06844
https://doi.org/10.1161/circulationaha.121.056076
https://doi.org/10.1161/circulationaha.121.056076
Publikováno v:
Dev Dyn
Background Heterochromatin protein 1 (HP1) is associated with and plays a role in compact chromatin conformation, but the function of HP1 in vertebrate embryogenesis is not understood completely. Results Here, we explore the activity of HP1 in early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2475da09be6e63145591304057e3c53e
https://pubmed.ncbi.nlm.nih.gov/33595886
https://pubmed.ncbi.nlm.nih.gov/33595886
Publikováno v:
Circulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615ba5c429cc33fb1ebe951375e9df11
https://pubmed.ncbi.nlm.nih.gov/32339045
https://pubmed.ncbi.nlm.nih.gov/32339045
Autor:
Chenbei Chang, Gordon P. Meares, Nicolas F. Berbari, Magda Gerigk, Rajani Rajbhandari, Markus Bredel, Amber L. Rowse, G. Kenneth Gray, Chih-Liang Tien, Susan Nozell, Sindhu Nair, Etty N. Benveniste, Kayln C. Mulhern, Samuel C. Fehling
Publikováno v:
Glia. 66:987-998
Previously, we determined microRNA-31 (miR-31) is a non-coding tumor suppressive gene frequently deleted in glioblastoma (GBM); miR-31 suppresses tumor growth, in part, by limiting the activity of NF-κB. Herein, we expand our previous studies by cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11525688eaacf2a9b3c86c872620100f
https://doi.org/10.1002/glia.23296
https://doi.org/10.1002/glia.23296
Publikováno v:
Circulation Research. 123
The onset and the injury of heart attacks both show a circadian rhythmicity with a peak during the sleep to active transition. Studies using cell type specific clock mutant demonstrated the intrinsic varying susceptibility of the cardiomyocytes to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16aaa902fdfd96baabd7cf78c4989698
https://doi.org/10.1161/res.123.suppl_1.431
https://doi.org/10.1161/res.123.suppl_1.431
Autor:
Rongli Zhang, Thomas P. Burris, Lilei Zhang, Xudong Liao, Austin C Griffin, Keiki Sugi, Chen Fu, Yuyan Shen, Ricky E Chan, Chih-Liang Tien, Mukesh K. Jain
Publikováno v:
JCI Insight. 2
A cure for heart failure remains a major unmet clinical need, and current therapies targeting neurohomonal and hemodynamic regulation have limited efficacy. The pathological remodeling of the myocardium has been associated with a stereotypical gene e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef24153af2233c43938528e4c7114c11
https://doi.org/10.1172/jci.insight.95177
https://doi.org/10.1172/jci.insight.95177
Publikováno v:
Neuroscience Letters. 454:152-156
Machado–Joseph disease is an autosomal dominant spinocerebellar degeneration caused by the expansion of a polyglutamine tract within the gene product, ataxin-3. We have previously shown that increased oxidative stress and decreased expression of Hs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a68ba95b80ac2d4d63fce4d4aa9fc4b
https://doi.org/10.1016/j.neulet.2009.03.004
https://doi.org/10.1016/j.neulet.2009.03.004