Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Chih-Li Lin"'
Autor:
Sing-Hua Tsou, Sheng-Chieh Lin, Wei-Jen Chen, Hui-Chih Hung, Chun-Cheng Liao, Edy Kornelius, Chien-Ning Huang, Chih-Li Lin, Yi-Sun Yang
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1444 (2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by excessive fat accumulation in the liver. Intracellular oxidative stress induced by lipid accumulation leads to various hepatocellular injuries including fibrosis. Ho
Externí odkaz:
https://doaj.org/article/f45733bea4b44a6a93c9c709193feab7
Autor:
Yi-Fang Yang, Chuang-Ming Wang, I.-Hsin Hsiao, Yi-Liang Liu, Wen-Hao Lin, Chih-Li Lin, Hui-Chih Hung, Guang-Yaw Liu
Publikováno v:
Cellular & Molecular Biology Letters, Vol 27, Iss 1, Pp 1-25 (2022)
Abstract Peptididylarginine deiminase type 2 (PADI2) catalyzes the conversion of arginine residues to citrulline residues on proteins. We demonstrate that PADI2 induces T cell activation and investigate how PADI2 promotes activated T cell autonomous
Externí odkaz:
https://doaj.org/article/802dbea7a5d24e36b93b82939b615eb4
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder involving progressive pancreatic dysfunction. A substantial proportion of patients with T2DM cannot achieve euglycemia despite pharmacologic therapy. Preceding clinical studies
Externí odkaz:
https://doaj.org/article/7eabdda7862c4873a2452a582b4961cc
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Insulin resistance could be associated with the development of Alzheimer disease (AD). The neuropathological hallmarks of AD are beta amyloid (Aβ) produced from sequential cleavage initiated by β-secretase and degraded by insuli
Externí odkaz:
https://doaj.org/article/ee04d100b4d34711a691fe8e5ef5e31e
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Nonalcoholic fatty liver disease (NAFLD) is recognized as the liver component of metabolic syndrome. The regulation of hepatic lipid should be emphasized to prevent accompanying illness. As AMP-activated protein kinase (AMPK) and sterol regulatory el
Externí odkaz:
https://doaj.org/article/88ddba1e8da34de69a9d3db62974e292
Autor:
Edy Kornelius, Sing-Hua Tsou, Ching-Chi Chang, Ying-Jui Ho, Sheng-Chieh Lin, Wei-Liang Chen, Chien-Ning Huang, Chih-Li Lin
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1338 (2022)
Diabetic neuropathy (DN) is a type of sensory nerve damage that can occur in patients with diabetes. Although the understanding of pathophysiology is incomplete, DN is often associated with structural and functional alterations of the affected neuron
Externí odkaz:
https://doaj.org/article/9836d3da7f50473d8f9de3f1076960e8
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 2, Pp 198-206 (2018)
A growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer's disease (AD). In particular, dysregulation of cholesterol homeostasis in the brain has been reported to considerably in
Externí odkaz:
https://doaj.org/article/22877bf82df34ce3b45599c47477b1f0
Autor:
Tatiana A. Korolenko, Nina I. Dubrovina, Marina V. Ovsyukova, Nataliya P. Bgatova, Michael V. Tenditnik, Alexander B. Pupyshev, Anna A. Akopyan, Natalya V. Goncharova, Chih-Li Lin, Evgeny L. Zavjalov, Maria A. Tikhonova, Tamara G. Amstislavskaya
Publikováno v:
Cells, Vol 10, Iss 10, p 2557 (2021)
Autophagy attenuation has been found in neurodegenerative diseases, aging, diabetes mellitus, and atherosclerosis. In experimental models of neurodegenerative diseases, the correction of autophagy in the brain reverses neuronal and behavioral deficit
Externí odkaz:
https://doaj.org/article/cff7cac16e3b438c8afab5d419c4b85b
Autor:
Chih-Li Lin, Ruijuan Xu, Jae Kyo Yi, Fang Li, Jiang Chen, Evan C. Jones, Jordan B. Slutsky, Liqun Huang, Basil Rigas, Jian Cao, Xiaoming Zhong, Ashley J. Snider, Lina M. Obeid, Yusuf A. Hannun, Cungui Mao
Publikováno v:
Stem Cell Reports, Vol 9, Iss 5, Pp 1488-1500 (2017)
Summary: Ceramides and their metabolites are important for the homeostasis of the epidermis, but much remains unknown about the roles of specific pathways of ceramide metabolism in skin biology. With a mouse model deficient in the alkaline ceramidase
Externí odkaz:
https://doaj.org/article/b32260bfe78b480f9413d2cad245e063
Autor:
Ying-Jui Ho, Mei-Shiuan Shen, Chun-Hwei Tai, Hsin-Hua Li, Jian-Horng Chen, Wen-Chieh Liao, Pai-Yi Chiu, I-Yen Lee, Chih-Li Lin, Ching-Sui Hung
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Dementia with Lewy bodies (DLB) is caused by accumulation of Lewy bodies, destruction of mitochondria, and excess of glutamate in synapses, which eventually leads to excitotoxicity, neurodegeneration, and cognitive impairments. Ceftriaxone (CEF) redu
Externí odkaz:
https://doaj.org/article/efa53133fe364b5ea162f722eee6c9b4