Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Chih-Jen Lai"'
Autor:
Dokyun Kim, Eunha Kim, Semi Kim, Youseung Chung, Chih-Jen Lai, Inho Cha, Sung-Dong Cho, Yunseo Choi, Xinghong Dai, Stephanie Kim, Seokmin Kang, Mi-Jeong Kwak, Ziyi Liu, Younho Choi, Su-Hyung Park, Young Ki Choi, Jae U. Jung
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Dabie bandavirus (DBV), previously known as severe fever with thrombocytopenia syndrome (SFTS) virus, induces a characteristic thrombocytopenia with a mortality rate ranging from 12% to as high as 30%. The sero-prevalence of DBV in healthy p
Externí odkaz:
https://doaj.org/article/6081eecbaf4b4ea0952b801b20c85d73
Autor:
Jinyeop Song, Bo-Seong Jeong, Seong-Woo Kim, Seong-Bin Im, Seonghoon Kim, Chih-Jen Lai, Wonki Cho, Jae U Jung, Myung-Ju Ahn, Byung-Ha Oh
Publikováno v:
eLife, Vol 12 (2023)
Immunoglobulin G (IgG) antibodies are widely used for diagnosis and therapy. Given the unique dimeric structure of IgG, we hypothesized that, by genetically fusing a homodimeric protein (catenator) to the C-terminus of IgG, reversible catenation of a
Externí odkaz:
https://doaj.org/article/63898ee2d57b4962bbcf50134986f256
Publikováno v:
Viruses, Vol 16, Iss 1, p 128 (2024)
SFTSV is an emerging tick-borne virus causing hemorrhagic fever with a case fatality rate (CFR) that can reach up to 27%. With endemic infection in East Asia and the recent spread of the vector tick to more than 20 states in the United States, the SF
Externí odkaz:
https://doaj.org/article/1934faf453d646d29ec87aedb8d63a38
Autor:
Tian Xia, Xin Wu, Eunjin Hong, Kyle Jung, Chih-Jen Lai, Mi-Jeong Kwak, Hogyu Seo, Stephanie Kim, Zhongyi Jiang, Inho Cha, Jae U Jung
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011232 (2023)
Due to climate changes, there has been a large expansion of emerging tick-borne zoonotic viruses, including Heartland bandavirus (HRTV) and Dabie bandavirus (DBV). As etiologic agents of hemorrhagic fever with high fatality, HRTV and DBV have been re
Externí odkaz:
https://doaj.org/article/5881408929ae41b6bb272edd69438342
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/f4b7829f502246228e068391dd769f8d
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
More than 80% of SARS-CoV-2 variants, including Alpha and Omicron, contain an N501Y mutation in the receptor-binding domain (RBD) of the spike protein. The N501Y change is an adaptive mutation enabling tighter interaction with the human ACE2 receptor
Externí odkaz:
https://doaj.org/article/bfc3c6c3b8b14652a2710c45c89cdd42
Autor:
Chang-Hsun Ho, Mei-Lin Chen, Hau-Lun Huang, Chih-Jen Lai, Chih-Hsin Liu, Chih-Pin Chuu, Yu-Hsin Lin
Publikováno v:
Marine Drugs, Vol 20, Iss 9, p 542 (2022)
The standard of care for prostate cancer (PCa) is androgen deprivation therapy (ADT). Although hormone-sensitive PCa is curable by ADT, most conditions progress to castration-resistant prostate cancer (CRPCa) and metastatic CRPCa (mCRPCa). Front-line
Externí odkaz:
https://doaj.org/article/bb95d9cf20d24da5a50da642f7b4c68d
Autor:
Young-Il Kim, Dokyun Kim, Kwang-Min Yu, Hogyu David Seo, Shin-Ae Lee, Mark Anthony B. Casel, Seung-Gyu Jang, Stephanie Kim, WooRam Jung, Chih-Jen Lai, Young Ki Choi, Jae U. Jung
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of the CoV disease 2019 (COVID-19) pandemic, enters host cells via the interaction of its receptor-binding domain (RBD) of the spike protein with host angiotensin-convert
Externí odkaz:
https://doaj.org/article/28c7b10f0f2446b1a7fdbe067aabdadd
Autor:
Ying-Yu Kuo, Wai-Tim Jim, Liang-Cheng Su, Chi-Jung Chung, Ching-Yu Lin, Chieh Huo, Jen-Chih Tseng, Shih-Han Huang, Chih-Jen Lai, Bo-Chih Chen, Bi-Juan Wang, Tzu-Min Chan, Hui-Ping Lin, Wun-Shaing Wayne Chang, Chuang-Rung Chang, Chih-Pin Chuu
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 5, Pp 10748-10766 (2015)
Head and neck cancers, which affect 650,000 people and cause 350,000 deaths per year, is the sixth leading cancer by cancer incidence and eighth by cancer-related death worldwide. Oral cancer is the most common type of head and neck cancer. More than
Externí odkaz:
https://doaj.org/article/f45b562dd00b40aaa9c480f89ca0b447
Publikováno v:
Cells, Vol 8, Iss 4, p 295 (2019)
Patients receiving docetaxel developed a drug resistance within a few months. We generated docetaxel-resistant PC/DX25 and DU/DX50 CRPC cells from PC-3 and DU-145 PCa cells, respectively. We investigated the mechanism behind why PC/DX25 and DU/DX50 c
Externí odkaz:
https://doaj.org/article/74778620261241d0960f9f020d1d9a5a