Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Chih-Hsin Lin"'
Autor:
Yih-Ru Wu, Kuo-Hsuan Chang, Chih-Ying Chao, Chih-Hsin Lin, Yi-Chun Chen, Tsai-Wei Liu, Guey-Jen Lee-Chen, Chiung-Mei Chen
Publikováno v:
Journal of the Formosan Medical Association, Vol 120, Iss 1, Pp 501-507 (2021)
Background: Oxidative stress could participate in the pathogenesis of Parkinson's disease (PD). However, the role of genetic variation of superoxide dismutase 2 (SOD2), an important regulator against oxidative stress, in PD remains to be elucidated.
Externí odkaz:
https://doaj.org/article/2ba9d2b2f09a43cfb151f6d1766de7a4
Autor:
Zheng-Kui Weng, Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Chih-Hsin Lin, Pei-Hsuan Tseng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen, Chiung-Mei Chen
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 219 (2023)
Misfolded aggregation of the hyperphosphorylated microtubule binding protein Tau in the brain is a pathological hallmark of Alzheimer’s disease (AD). Tau aggregation downregulates brain-derived neurotrophic factor (BDNF)/tropomycin receptor kinase
Externí odkaz:
https://doaj.org/article/9934b3950a89424da630b45ecdf060e8
Autor:
Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Pei-Ning Yang, Yen-Shi Lo, Yu-Chieh Chen, Chiung-Mei Chen, Yih-Ru Wu, Ching-Fa Yao, Kuo-Hsuan Chang, Guey-Jen Lee-Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2642 (2023)
Neuroinflammation and oxidative stress have been emerging as important pathways contributing to Parkinson’s disease (PD) pathogenesis. In PD brains, the activated microglia release inflammatory factors such as interleukin (IL)-β, IL-6, tumor necro
Externí odkaz:
https://doaj.org/article/3a8fda2e57474564a02e5f9ac62e56be
Gelatin Methacrylate Hydrogel for Tissue Engineering Applications—A Review on Material Modifications
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 171 (2022)
To recreate or substitute tissue in vivo is a complicated endeavor that requires biomaterials that can mimic the natural tissue environment. Gelatin methacrylate (GelMA) is created through covalent bonding of naturally derived polymer gelatin and met
Externí odkaz:
https://doaj.org/article/15c5837dc4ea493a9dcdee7ecefef300
Autor:
Chih-Hsin Lin, Pei-Cih Wei, Chiung-Mei Chen, Yu-Ting Huang, Jia-Lan Lin, Yen-Shi Lo, Jia-Li Lin, Chung-Yin Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the progressive loss of dopaminergic (DAergic) neurons in the ventral brain. A disaccharide trehalose has demonstrated the potential to mitigate the DAergic loss in dis
Externí odkaz:
https://doaj.org/article/1d8786097293497c8f665e0bdeb5344f
Autor:
Daniel Reker, Yunhua Shi, Ameya R. Kirtane, Kaitlyn Hess, Grace J. Zhong, Evan Crane, Chih-Hsin Lin, Robert Langer, Giovanni Traverso
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3710-3716.e4 (2020)
Summary: Inactive ingredients and generally recognized as safe compounds are regarded by the US Food and Drug Administration (FDA) as benign for human consumption within specified dose ranges, but a growing body of research has revealed that many ina
Externí odkaz:
https://doaj.org/article/fd986bf05042470bae906a99e91ac6a3
Publikováno v:
Polymers, Vol 13, Iss 14, p 2354 (2021)
Gelatin methacryloyl (GelMA) hydrogel is a photopolymerizable biomaterial widely used for three-dimensional (3D) cell culture due to its high biocompatibility. However, the drawback of GelMA hydrogel is its poor mechanical properties, which may compr
Externí odkaz:
https://doaj.org/article/acd8436ce249487c986c7dc8c97c37d4
Publikováno v:
Nanomaterials, Vol 11, Iss 7, p 1727 (2021)
Anticancer nanomedicines have been studied over 30 years, but fewer than 10 formulations have been approved for clinical therapy today. Despite abundant options of anticancer drugs, it remains challenging to have agents specifically target cancer cel
Externí odkaz:
https://doaj.org/article/4868138b586a4a2db013e70594640c53
Autor:
Kuo-Hsuan Chang, Chiung-Mei Chen, Chih-Hsin Lin, Wen-Teng Chang, Pei-Ru Jiang, Ya-Chin Hsiao, Yih-Ru Wu, Guey-Jen Lee-Chen
Publikováno v:
Journal of the Formosan Medical Association, Vol 116, Iss 3, Pp 197-204 (2017)
Leucine-rich repeat kinase 2 (LRRK2) is a large protein encoding multiple functional domains. Mutations within different LRRK2 domains have been considered to be involved in the development of Parkinson disease by different mechanisms. Our previous s
Externí odkaz:
https://doaj.org/article/cc623358c56a4e4c9f36a432c2ad0b6e
Autor:
Chiung-Mei Chen, Chien-Yu Yen, Wan-Ling Chen, Chih-Hsin Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1062 (2021)
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic (DAergic) neurons and the presence of α-synuclein-containing Lewy bodies. The unstructured α-synuclein forms insoluble fibrils and aggregate
Externí odkaz:
https://doaj.org/article/42aff551a4ce40ea90127ece683cac5f