Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Chih Yung Tang"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Loss-of-function mutations in the human gene encoding the neuron-specific Ca2+ channel CaV2.1 are linked to the neurological disease episodic ataxia type 2 (EA2), as well as neurodevelopmental disorders such as developmental delay and develo
Externí odkaz:
https://doaj.org/article/c101447efafa40999fb74b6482cc9c59
Autor:
Chang-Heng Hsieh, Chia-Cheng Chou, Ya-Ching Fang, Po-Hao Hsu, Yi-Hung Chiu, Chi-Sheng Yang, Guey-Mei Jow, Chih-Yung Tang, Chung-Jiuan Jeng
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-24 (2023)
Abstract Background Mutations in the human gene encoding the neuron-specific Eag1 (KV10.1; KCNH1) potassium channel are linked to congenital neurodevelopmental diseases. Disease-causing mutant Eag1 channels manifest aberrant gating function and defec
Externí odkaz:
https://doaj.org/article/c9fe821cf1bb4203a23a19546faaf519
Autor:
Chung-Jiuan Jeng, Ssu-Ju Fu, Chia-Ying You, Yi-Jheng Peng, Cheng-Tsung Hsiao, Tsung-Yu Chen, Chih-Yung Tang
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
The voltage-dependent ClC-1 chloride channel, whose open probability increases with membrane potential depolarization, belongs to the superfamily of CLC channels/transporters. ClC-1 is almost exclusively expressed in skeletal muscles and is essential
Externí odkaz:
https://doaj.org/article/ff9b0382f8cd4703acbf7270b4cd1390
Publikováno v:
IBRO Reports, Vol 2, Iss C, Pp 63-71 (2017)
Ca2+ influx through voltage-gated Ca2+ channels (CaVs) at the plasma membrane is the major pathway responsible for the elevation of the intracellular Ca2+ concentration ([Ca2+]i), which activates various physiological activities. Calmodulin (CaM) is
Externí odkaz:
https://doaj.org/article/8e40fc5794ec4643a60502f05acc2d43
Autor:
Ssu-Ju Fu, Meng-Chun Hu, Yi-Jheng Peng, Hsin-Yu Fang, Cheng-Tsung Hsiao, Tsung-Yu Chen, Chung-Jiuan Jeng, Chih-Yung Tang
Publikováno v:
Cells, Vol 9, Iss 6, p 1332 (2020)
Voltage-gated ClC-2 channels are essential for chloride homeostasis. Complete knockout of mouse ClC-2 leads to testicular degeneration and neuronal myelin vacuolation. Gain-of-function and loss-of-function mutations in the ClC-2-encoding human CLCN2
Externí odkaz:
https://doaj.org/article/8820b3f04a634771ac8403cf89d97a3e
Autor:
Fan-Lu Kung, Jung-Lung Tsai, Chien-Hsing Lee, Kuo-Long Lou, Chih-Yung Tang, Horng-Huei Liou, Kuan-Ling Lu, Yi-Hung Chen, Wun-Jheng Wang, Ming-Cheng Tsai
Publikováno v:
Journal of the Formosan Medical Association, Vol 107, Iss 8, Pp 600-608 (2008)
Background/Purpose: Inward rectifying potassium channel 6.2 (Kir6.2 Δ C26 channel) is closely related to ATP-sensitive potassium channels. Whether sodium azide, barium ion, d-amphetamine or procaine acts directly on the Kir6.2 Δ C26 channel remains
Externí odkaz:
https://doaj.org/article/f4bc47890e5a48a9bb418c136a1ff423
Autor:
Ssu Ju Fu, Chung Jiuan Jeng, Cheng Tsung Hsiao, Chih Yung Tang, Thomas F. Tropea, Tanya Bardakjian, Bing Wen Soong, Pedro Gonzalez-Alegre
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 8247, p 8247 (2021)
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8247, p 8247 (2021)
Volume 22
Issue 15
Loss-of-function mutations in the KV4.3 channel-encoding KCND3 gene are linked to neurodegenerative cerebellar ataxia. Patients suffering from neurodegeneration associated with iron deposition may also present with cerebellar ataxia. The mechanism un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bcfeb920e03ebb3e572284c99154f27
http://europepmc.org/articles/PMC8347726
http://europepmc.org/articles/PMC8347726
Autor:
Bing-Wen Soong, Ssu Ju Fu, Yo Tsen Liu, Ciao Yu Zhong, Chung Jiuan Jeng, Cheng Tsung Hsiao, Chih Yung Tang, Yi Hsiang Lu
Publikováno v:
Human Mutation. 40:2088-2107
Mutations in the human voltage-gated K+ channel subunit KV 4.3-encoding KCND3 gene have been associated with the autosomal dominant neurodegenerative disorder spinocerebellar ataxia types 19 and 22 (SCA19/22). The precise pathophysiology underlying t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b249f1cbe6addaf077d48b707eb547c
https://doi.org/10.1002/humu.23865
https://doi.org/10.1002/humu.23865
Autor:
Meng Chun Hu, Chung Jiuan Jeng, Tsung-Yu Chen, Ssu Ju Fu, An Ting Cheng, Cheng Tsung Hsiao, Chih Yung Tang
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 11; Pages: 5859
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5859, p 5859 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5859, p 5859 (2021)
The ClC-2 channel plays a critical role in maintaining ion homeostasis in the brain and the testis. Loss-of-function mutations in the ClC-2-encoding human CLCN2 gene are linked to the white matter disease leukodystrophy. Clcn2-deficient mice display
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97eaa45dedb72e931a02ec77bb407189
Autor:
Bing-Wen Soong, Chen Tsung Hsiao, Luca Bosco, Emanuele Bellacchio, Alessandro Capuano, Chung Jiuan Jeng, Guido Primiano, Ginevra Zanni, Serenella Servidei, Chih Yung Tang, Federica Graziola, Ssu Ju Fu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4986, p 4986 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences
Volume 22
Issue 9
KCND3 encodes the voltage-gated potassium channel KV4.3 that is highly expressed in the cerebellum, where it regulates dendritic excitability and calcium influx. Loss-of-function KV4.3 mutations have been associated with dominant spinocerebellar atax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab372a8768c30c9f31a2041c52011c94
https://www.mdpi.com/1422-0067/22/9/4986
https://www.mdpi.com/1422-0067/22/9/4986