Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Chih Yung S. Lee"'
Publikováno v:
eLife, Vol 9 (2020)
RNA granules are protein/RNA condensates. How specific mRNAs are recruited to cytoplasmic RNA granules is not known. Here, we characterize the transcriptome and assembly of P granules, RNA granules in the C. elegans germ plasm. We find that P granule
Externí odkaz:
https://doaj.org/article/9e4b10e3533e4857b1b554528c08c9fe
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
RNA granules are protein/RNA condensates. How specific mRNAs are recruited to cytoplasmic RNA granules is not known. Here, we characterize the transcriptome and assembly of P granules, RNA granules in the C. elegans germ plasm. We find that P granule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbe150959aa36274c62c6d538e5099a
https://doi.org/10.7554/elife.52896
https://doi.org/10.7554/elife.52896
Publikováno v:
PLoS Genetics, Vol 3, Iss 8, p e131 (2007)
Retrotransposons are mobile genetic elements that proliferate through an RNA intermediate. Transposons do not encode transcription factors and thus rely on host factors for mRNA expression and survival. Despite information regarding conditions under
Externí odkaz:
https://doaj.org/article/0c9ef371f0ac487fa341fe43773498b7
Animals with germ plasm assemble cytoplasmic RNA granules (germ granules) that segregate with the embryonic germ lineage. How germ granules assemble and recruit RNA is not well understood. Here we characterize the assembly and RNA composition of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0145df57aa24d4022cbdce2094d5bc7
Autor:
Geraldine Seydoux, Chih Yung S. Lee
Publikováno v:
Nature Cell Biology. 21:116-117
Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50f898312afe6f919ee405a06bf6fe06
https://doi.org/10.1038/s41556-019-0278-5
https://doi.org/10.1038/s41556-019-0278-5
The Nanos RNA-binding protein has been implicated in the specification of primordial germ cells (PGCs) in metazoans, but the underlying mechanisms remain poorly understood. We have profiled the transcriptome of PGCs lacking thenanoshomologuesnos-1and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d5c1925ffb7f026dfaa856ec0a151c
https://doi.org/10.1101/163642
https://doi.org/10.1101/163642
Autor:
Chih Yung S. Lee, Alexandre Paix, Harold E. Smith, Jarrett Smith, Deepika Calidas, Yuemeng Wang, Michael W. Krause, Helen Schmidt, Tu Lu, Geraldine Seydoux
Publikováno v:
Genetics
Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome editing, but is thought to be less efficient than error-prone nonhomologous end joining in most cell types. We have investigated HDR of double-strand breaks i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7981511489a271d60f4ed6a00e7b422
https://doi.org/10.1534/genetics.114.170423
https://doi.org/10.1534/genetics.114.170423
Autor:
Andrew Folkmann, Amanda Charlesworth, Chih Yung S. Lee, Lauren Bernard, Geraldine Seydoux, John Paul T. Ouyang, Uri Seroussi, Julie M. Claycomb
Publikováno v:
Dev Cell
SUMMARYP granules are perinuclear condensates in C. elegans germ cells proposed to serve as hubs for self/non-self RNA discrimination by Argonautes. We report that a mutant (meg-3 meg-4) that does not assemble P granules in primordial germ cells lose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00afeace4918aee75dd9320ffd1a63d9
https://doi.org/10.1016/j.devcel.2019.07.026
https://doi.org/10.1016/j.devcel.2019.07.026
Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA bindingand degradation
Publikováno v:
Molecular Biology of the Cell
The prolyl hydroxylase Ofd1 enables yeast cells to adapt to hypoxia by regulating the DNA binding and degradation of the hypoxic transcription factor Sre1N. These two regulatory functions are inseparable in vivo. A mathematical model of the Ofd1 syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c7aa048d0954b76090d72d2e5b935b
http://europepmc.org/articles/PMC3442422
http://europepmc.org/articles/PMC3442422