Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Chih Chao Liang"'
Autor:
Anaid Benitez, Marie Sebald, Radhakrishnan Kanagaraj, Monica C. Rodrigo-Brenni, Ying Wai Chan, Chih-Chao Liang, Stephen C. West
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112062- (2023)
Summary: Our genomes harbor conserved DNA sequences, known as common fragile sites (CFSs), that are difficult to replicate and correspond to regions of genome instability. Following replication stress, CFS loci give rise to breaks or gaps (termed CFS
Externí odkaz:
https://doaj.org/article/5ee6d94af6324807961f58a87846f6c4
Autor:
Chih-Chao Liang, Martin A. Cohn
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100348- (2021)
Summary: Cells possess multiple DNA repair pathways to tackle a variety of DNA lesions. Often, DNA repair proteins function as large protein complexes. Here, we describe a protocol to purify DNA repair protein complexes from nuclei of mammalian cells
Externí odkaz:
https://doaj.org/article/b0cd4c24efd14ed6a19dabff89ac40c0
Autor:
Sarah J. Young, Marie Sebald, Rajvee Shah Punatar, Meghan Larin, Laura Masino, Monica C. Rodrigo-Brenni, Chih-Chao Liang, Stephen C. West
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108289- (2020)
Summary: MutSα and MutSβ play important roles in DNA mismatch repair and are linked to inheritable cancers and degenerative disorders. Here, we show that MSH2 and MSH3, the two components of MutSβ, bind SLX4 protein, a scaffold for the assembly of
Externí odkaz:
https://doaj.org/article/fcd87da1d9a44e2dbf954e4228e5b795
Autor:
David Lopez-Martinez, Marian Kupculak, Di Yang, Yasunaga Yoshikawa, Chih-Chao Liang, Ronghu Wu, Steven P. Gygi, Martin A. Cohn
Publikováno v:
Cell Reports, Vol 27, Iss 10, Pp 2990-3005.e5 (2019)
Summary: Interstrand crosslinks (ICLs) of the DNA helix are a deleterious form of DNA damage. ICLs can be repaired by the Fanconi anemia pathway. At the center of the pathway is the FANCD2/FANCI complex, recruitment of which to DNA is a critical step
Externí odkaz:
https://doaj.org/article/8b1b2e0eb6dc4f549943a994d0233d7e
Autor:
Chih-Chao Liang, Zhuolun Li, David Lopez-Martinez, William V. Nicholson, Catherine Vénien-Bryan, Martin A. Cohn
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2-FANCI complex, providing insight into how the complex is recruited to stalled replication forks.
Externí odkaz:
https://doaj.org/article/c919cf65091d44ba84e82fd2b5331de6
Publikováno v:
Key Engineering Materials. 905:333-337
In the period of silicon and silicon carbide wafer slicing process, the abrasive oil, silicon carbide (SiC), silicon and trace elements e.g., iron, zinc, copper, and nickel is generated as an oily mixture of insoluble matter. The SiC is the main comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5ad27b8ce8ea0238e360a88af5e287a
https://doi.org/10.4028/www.scientific.net/kem.905.333
https://doi.org/10.4028/www.scientific.net/kem.905.333
Autor:
Anna Motnenko, Chih-Chao Liang, Di Yang, David Lopez-Martinez, Yasunaga Yoshikawa, Bao Zhan, Katherine E Ward, Jiayang Tian, Wilhelm Haas, Paolo Spingardi, Benedikt M Kessler, Skirmantas Kriaucionis, Steven P Gygi, Martin A Cohn
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007643 (2018)
The Fanconi Anemia (FA) pathway is important for repairing interstrand crosslinks (ICLs) between the Watson-Crick strands of the DNA double helix. An initial and essential stage in the repair process is the detection of the ICL. Here, we report the i
Externí odkaz:
https://doaj.org/article/0732015a852349df980e56c133ef0fcb
Publikováno v:
Cell Reports, Vol 10, Iss 12, Pp 1947-1956 (2015)
The Fanconi anemia (FA) pathway is critical for the cellular response to toxic DNA interstrand crosslinks (ICLs). Using a biochemical purification strategy, we identified UHRF1 as a protein that specifically interacts with ICLs in vitro and in vivo.
Externí odkaz:
https://doaj.org/article/a1d9f7c26ed34c688c2f85208c881d4d
Publikováno v:
Journal of Physics: Conference Series. 2468:012100
In this study, the aluminum dross collected in the production process of the aluminum smelting industry was used as the raw material for mixing with an alkaline solution to make aluminum hydroxide where aluminum was extracted by a titration procedure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5a9867b78fe60eb140dc9f5476a9aa9
https://doi.org/10.1088/1742-6596/2468/1/012100
https://doi.org/10.1088/1742-6596/2468/1/012100
UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity
Autor:
Chih-Chao Liang, Alan R. Lehmann, Martin A. Cohn, Federica Bertoletti, Simone Sabbioneda, Lina Cipolla, Antonio Maffia
Publikováno v:
Nucleic Acids Research
Accurate DNA replication is critical for the maintenance of genome integrity and cellular survival. Cancer-associated alterations often involve key players of DNA replication and of the DNA damage-signalling cascade. Post-translational modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73da0f9d7cdf36a841ae9c182c6d62c
https://doi.org/10.1093/nar/gkz824
https://doi.org/10.1093/nar/gkz824