Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Chih‐Hong Lou"'
Autor:
Tamara Mirzapoiazova, Liz Tseng, Bolot Mambetsariev, Haiqing Li, Chih-Hong Lou, Alex Pozhitkov, Sravani Keerthi Ramisetty, Sangkil Nam, Isa Mambetsariev, Brian Armstrong, Jyoti Malhotra, Leonidas Arvanitis, Mohd Wasim Nasser, Surinder K. Batra, Steven T. Rosen, Deric L. Wheeler, Sharad S. Singhal, Prakash Kulkarni, Ravi Salgia
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110132- (2024)
Summary: Although up to 80% small cell lung cancer (SCLC) patients’ response is good for first-line chemotherapy regimen, most patients develop recurrence of the disease within weeks to months. Here, we report cytostatic effect of leflunomide (Lefl
Externí odkaz:
https://doaj.org/article/c1d2afcf8682490aa1a6bb5963b1e1f1
Autor:
Xiaofang Tang, Yingjun Luo, Dongqiang Yuan, Riccardo Calandrelli, Naseeb Kaur Malhi, Kiran Sriram, Yifei Miao, Chih-Hong Lou, Walter Tsark, Alonso Tapia, Aleysha T. Chen, Guangyu Zhang, Daniel Roeth, Markus Kalkum, Zhao V. Wang, Shu Chien, Rama Natarajan, John P. Cooke, Sheng Zhong, Zhen Bouman Chen
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Impaired angiogenesis in diabetes is a key process contributing to ischemic diseases such as peripheral arterial disease. Epigenetic mechanisms, including those mediated by long noncoding RNAs (lncRNAs), are crucial links connecting diabetes and the
Externí odkaz:
https://doaj.org/article/17124107ddb64a87bca90326d3684d5f
Autor:
Gehong Dong, Yuping Li, Logan Lee, Xuxiang Liu, Yunfei Shi, Xiaoqian Liu, Alyssa Bouska, Qiang Gong, Lingbo Kong, Jinhui Wang, Chih-Hong Lou, Timothy W. McKeithan, Javeed Iqbal, Wing C. Chan
Publikováno v:
Haematologica, Vol 106, Iss 9 (2020)
Extra-nodal natural killer/T-cell lymphoma, nasal type (ENKTCL) is a highly aggressive lymphoma, where the tumor suppressor gene (TSG) PRDM1 is frequently lost/inactivated. We employed two different CRISPR/Cas9 approaches to generate PRDM1-/- primary
Externí odkaz:
https://doaj.org/article/b90b7fcf8a004c0eac1d1ca4bd97e208
Autor:
Yifei Miao, Nassim E. Ajami, Tse-Shun Huang, Feng-Mao Lin, Chih-Hong Lou, Yun-Ting Wang, Shuai Li, Jian Kang, Hannah Munkacsi, Mano R. Maurya, Shakti Gupta, Shu Chien, Shankar Subramaniam, Zhen Chen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
eNOS expression is dynamically regulated both transcriptionally and post-transcriptionally by various stimuli. Here the authors identify an enhancer-associated lncRNA (LEENE) that is co-regulated with, and enhances eNOS expression.
Externí odkaz:
https://doaj.org/article/a67095a0978f4a1bbc2ae67affad3970
Autor:
Soo-Mi Kweon, Jose Irimia-Dominguez, Gayeoun Kim, Patrick T. Fueger, Kinji Asahina, Keith K. Lai, Daniela S. Allende, Quincy R. Lai, Chih-Hong Lou, Walter M. Tsark, Ju Dong Yang, Dominic S. Ng, Ju-Seog Lee, Patrick Tso, Wendong Huang, Keane K.Y. Lai
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology.
Although midnolin has been studied for over 20 years, its biological roles in vivo remain largely unknown, especially due to the lack of a functional animal model. Indeed, given our recent discovery that knockdown of midnolin suppresses liver cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df00c74f49dbfdd38891754a9ac979aa
https://doi.org/10.1152/ajpgi.00011.2023
https://doi.org/10.1152/ajpgi.00011.2023
Autor:
Chih-Hong Lou, Jennifer Dumdie, Alexandra Goetz, Eleen Y. Shum, David Brafman, Xiaoyan Liao, Sergio Mora-Castilla, Madhuvanthi Ramaiah, Heidi Cook-Andersen, Louise Laurent, Miles F. Wilkinson
Publikováno v:
Stem Cell Reports, Vol 6, Iss 6, Pp 844-857 (2016)
Summary: Nonsense-mediated RNA decay (NMD) is a highly conserved pathway that selectively degrades specific subsets of RNA transcripts. Here, we provide evidence that NMD regulates early human developmental cell fate. We found that NMD factors tend t
Externí odkaz:
https://doaj.org/article/98086608a1714f32a8e3dc874d165deb
Autor:
Lingbo Kong, Wing C. Chan, Logan Lee, Javeed Iqbal, Jinhui Wang, Timothy W. McKeithan, Xiaoqian Liu, Alyssa Bouska, Chih Hong Lou, Qiang Gong, Gehong Dong, Yuping Li, Yunfei Shi, Xuxiang Liu
Publikováno v:
Haematologica
Extra-nodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL) is a highly aggressive lymphoma, in which the tumor suppressor gene PRDM1 is frequently lost or inactivated. We employed two different CRISPR/Cas9 approaches to generate PRDM1-/- pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cc1a0d6019fd36d92aaca353209245
https://doi.org/10.3324/haematol.2020.254276
https://doi.org/10.3324/haematol.2020.254276
Autor:
Punnajit Lim, Chih-Hong Lou, Yusuke Higuchi, Jia-Ling Teo, Xiaohui Hu, Nyam-Osor Chimge, Patrick T. Fueger, Keisuke Chosa, Elizabeth Melendez, Keane K. Y. Lai, Masaya Ono, Michael G. Kahn, John Termini, Cu Nguyen
Publikováno v:
Cancers, Vol 13, Iss 5884, p 5884 (2021)
Cancers; Volume 13; Issue 23; Pages: 5884
Cancers
Cancers; Volume 13; Issue 23; Pages: 5884
Cancers
Simple Summary The coupling of metabolism with cellular status is critically important and highly evolutionarily conserved. However, how cells coordinate metabolism with transcription as they change their status is not clear. Utilizing multiomic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd3fbb1c5848e252ef414dd7303e0e6
https://www.mdpi.com/2072-6694/13/23/5884
https://www.mdpi.com/2072-6694/13/23/5884
Autor:
Anjana Bhardwaj, Abhishek Sohni, Chih-Hong Lou, Karel De Gendt, Fanmao Zhang, Eunah Kim, Panneerdoss Subbarayalu, Waikin Chan, Stefanie Kerkhofs, Frank Claessens, Sarah Kimmins, Manjeet K Rao, Marvin Meistrich, Miles F Wilkinson
Publikováno v:
Endocrinology
Concordant transcriptional regulation can generate multiple gene products that collaborate to achieve a common goal. Here we report a case of concordant transcriptional regulation that instead drives a single protein to be produced in the same cell t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740c9140701f8f8d53d79429b71d3016
https://pubmed.ncbi.nlm.nih.gov/34902009
https://pubmed.ncbi.nlm.nih.gov/34902009
Autor:
Amanda J. Roberts, Jozef Gecz, Josh L. Espinoza, Mimi H. Phan, Miles F. Wilkinson, Heidi Cook-Andersen, Jennifer N Dumdie, David Skarbrevik, Samantha H Jones, Neal R. Swerdlow, Chih-Hong Lou, Lulu Huang, Lachlan A. Jolly, Eleen Shum, Kim H
Publikováno v:
Molecular psychiatry, vol 23, iss 8
Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts. NMD is regulated in a tissue-specific and developmentally controlled manner, raisin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56ceebdabc4fe42e203d813e4d9b135
https://doi.org/10.1038/mp.2017.173
https://doi.org/10.1038/mp.2017.173