Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Chih‐Chiang Chan"'
Autor:
Jui-Yu Yeh, Hua-Chuan Chao, Cheng-Li Hong, Yu-Chien Hung, Fei-Yang Tzou, Cheng-Tsung Hsiao, Jeng-Lin Li, Wen-Jie Chen, Cheng-Ta Chou, Yu-Shuen Tsai, Yi-Chu Liao, Yu-Chun Lin, Suewei Lin, Shu-Yi Huang, Marina Kennerson, Yi-Chung Lee, Chih-Chiang Chan
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 5, Pp 1091-1114 (2024)
Abstract PAR3/INSC/LGN form an evolutionarily conserved complex required for asymmetric cell division in the developing brain, but its post-developmental function and disease relevance in the peripheral nervous system (PNS) remains unknown. We mapped
Externí odkaz:
https://doaj.org/article/5359f09eb23c4e93a0c5ca897d7a0804
Autor:
Kun-Yang Lin, Wen-Der Wang, Chi-Hung Lin, Elham Rastegari, Yu-Han Su, Yu-Tzu Chang, Yung-Feng Liao, Yi-Chieh Chang, Haiwei Pi, Bo-Yi Yu, Shu-Hwa Chen, Chung-Yen Lin, Mei-Yeh Lu, Tsu-Yi Su, Fei-Yang Tzou, Chih-Chiang Chan, Hwei-Jan Hsu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Retrotransposons are known to be involved in aging. Here the authors show that the retrotransposon silencer Piwi contributes to germline stem cell loss during aging in Drosophila.
Externí odkaz:
https://doaj.org/article/f818031002264c058f9fd632e6d09a5a
Mitochondrial Function and Parkinson’s Disease: From the Perspective of the Electron Transport Chain
Autor:
Jeng-Lin Li, Tai-Yi Lin, Po-Lin Chen, Ting-Ni Guo, Shu-Yi Huang, Chun-Hong Chen, Chin-Hsien Lin, Chih-Chiang Chan
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Parkinson’s disease (PD) is known as a mitochondrial disease. Some even regarded it specifically as a disorder of the complex I of the electron transport chain (ETC). The ETC is fundamental for mitochondrial energy production which is essential for
Externí odkaz:
https://doaj.org/article/18714a49deee42e988cb053a52a5efb9
Autor:
Chen-Yi Wu, Jhih-Gang Jhang, Wan-Syuan Lin, Pei-Huan Chuang, Chih-Wei Lin, Li-An Chu, Ann-Shyn Chiang, Han-Chen Ho, Chih-Chiang Chan, Shu-Yi Huang
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103437- (2021)
Summary: Exosomes are important for cell–cell communication. Deficiencies in the human dihydroceramide desaturase gene, DEGS1, increase the dihydroceramide-to-ceramide ratio and cause hypomyelinating leukodystrophy. However, the disease mechanism r
Externí odkaz:
https://doaj.org/article/d55d5ad4e81547aca45b87af80fcaba8
Autor:
Yu-Chien Hung, Kuan-Lin Huang, Po-Lin Chen, Jeng-Lin Li, Serena Huei-An Lu, Jui-Chih Chang, Han-Yi Lin, Wen-Chun Lo, Shu-Yi Huang, Tai-Ting Lee, Tai-Yi Lin, Yuzuru Imai, Nobutaka Hattori, Chin-San Liu, Su-Yi Tsai, Chun-Hong Chen, Chin-Hsien Lin, Chih-Chiang Chan
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109729- (2021)
Summary: Human ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) is an evolutionarily conserved core subunit of mitochondrial respiratory chain complex III. We recently identified the disease-associated variants of UQCRC1 from patients with fa
Externí odkaz:
https://doaj.org/article/ab4d2d7451494750a93b10dd3d60e8b3
Autor:
Fei-Yang Tzou, Tsu-Yi Su, Wan-Syuan Lin, Han-Chun Kuo, Yu-Lian Yu, Yu-Han Yeh, Chung-Chih Liu, Ching-Hua Kuo, Shu-Yi Huang, Chih-Chiang Chan
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108972- (2021)
Summary: Disruption of sphingolipid homeostasis is known to cause neurological disorders, but the mechanisms by which specific sphingolipid species modulate pathogenesis remain unclear. The last step of de novo sphingolipid synthesis is the conversio
Externí odkaz:
https://doaj.org/article/d549c70fb1f546f3ba3ccb7c7a1fdb6b
Autor:
Friederike E Kohrs, Ilsa-Maria Daumann, Bojana Pavlovic, Eugene Jennifer Jin, F Ridvan Kiral, Shih-Ching Lin, Filip Port, Heike Wolfenberg, Thomas F Mathejczyk, Gerit A Linneweber, Chih-Chiang Chan, Michael Boutros, P Robin Hiesinger
Publikováno v:
eLife, Vol 10 (2021)
Rab GTPases are molecular switches that regulate membrane trafficking in all cells. Neurons have particular demands on membrane trafficking and express numerous Rab GTPases of unknown function. Here, we report the generation and characterization of m
Externí odkaz:
https://doaj.org/article/1d73470d06fd4145826f1e3724bfe42d
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 8 (2020)
Maple syrup urine disease (MSUD) is an inherited error in the metabolism of branched-chain amino acids (BCAAs) caused by a severe deficiency of the branched-chain α-ketoacid dehydrogenase (BCKDH) complex, which ultimately leads to neurological disor
Externí odkaz:
https://doaj.org/article/239a50f00f7946199d4f946cf053c179
Autor:
Jung-Kun Wen, Yi-Ting Wang, Chih-Chiang Chan, Cheng-Wen Hsieh, Hsiao-Man Liao, Chin-Chun Hung, Guang-Chao Chen
Publikováno v:
eLife, Vol 6 (2017)
Autophagy is essential for maintaining cellular homeostasis and survival under various stress conditions. Autophagy-related gene 9 (Atg9) encodes a multipass transmembrane protein thought to act as a membrane carrier for forming autophagosomes. Howev
Externí odkaz:
https://doaj.org/article/b0e14c26d7834408bb452097e7b91d5e
Autor:
Smita Cherry, Eugene Jennifer Jin, Mehmet Neset Özel, Zhiyuan Lu, Egemen Agi, Dong Wang, Wei-Hung Jung, Daniel Epstein, Ian A Meinertzhagen, Chih-Chiang Chan, P Robin Hiesinger
Publikováno v:
eLife, Vol 2 (2013)
The small GTPase Rab7 is a key regulator of endosomal maturation in eukaryotic cells. Mutations in rab7 are thought to cause the dominant neuropathy Charcot-Marie-Tooth 2B (CMT2B) by a gain-of-function mechanism. Here we show that loss of rab7, but n
Externí odkaz:
https://doaj.org/article/768194f82ab142ea8d1eef5d042a5971