Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Chien-Ming Hsieh"'
Autor:
Ming-Thau Sheu, Shyr-Yi Lin, Wei-Jie Cheng, Hong-Liang Lin, Chien-Ming Hsieh, Hsiu-O Ho, Ling-Chun Chen, Meng-Huang Wu
Publikováno v:
Carbohydrate Polymer Technologies and Applications, Vol 8, Iss , Pp 100576- (2024)
Bone regeneration remains a critical challenge in orthopedic medicine. Extracellular matrix proteins play important roles in bionic mineralization and osteogenesis. Sacchachitin nanofibers (SCNFs) oxidized via TEMPO have shown great potential as biom
Externí odkaz:
https://doaj.org/article/5a9309ef1bb945cbb70d4acbb2e1c5a2
Autor:
Athika Darumas Putri, Bayu Tri Murti, Yankuba B. Manga, Suvardhan Kanchi, Yi‐June Huang, Chih‐Wei Peng, Po‐Kang Yang, Chien‐Ming Hsieh
Publikováno v:
Advanced Sensor Research, Vol 3, Iss 5, Pp n/a-n/a (2024)
Abstract Cancer is one of the most life‐threatening diseases worldwide. Numerous diagnostic and therapeutic techniques, such as nanomaterials‐based cancer detection and imaging‐guided focal therapy, are successfully developed to achieve highly
Externí odkaz:
https://doaj.org/article/ecc1454d653840908e59b27e7b8e4a5b
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115636- (2023)
Doxorubicin is a widely-used chemotherapeutic drug, however its high toxicity poses a significant challenge for its clinical use. To address this issue, a physiologically-based pharmacokinetic (PBPK) model was implemented to quantitatively assess dox
Externí odkaz:
https://doaj.org/article/39991fef80c34e1191d6c48f6f7edb3f
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 283 (2023)
Oral delivery has become the route of choice among all other types of drug administrations. However, typical chronic disease drugs are often poorly water-soluble, have low dissolution rates, and undergo first-pass metabolism, ultimately leading to lo
Externí odkaz:
https://doaj.org/article/8a0d5c610f7142d79291ec4413f11392
Autor:
Ling-Chun Chen, Wei-Jie Cheng, Shyr-Yi Lin, Ming-Tse Hung, Ming-Thau Sheu, Hong-Liang Lin, Chien-Ming Hsieh
Publikováno v:
Drug Delivery, Vol 28, Iss 1, Pp 2205-2217 (2021)
Therapeutic efficacies of orally administrated hydrophobic chemodrugs are decreased by poor water solubilities and reduced oral bioavailabilities by P-glycoprotein (P-gp) and CYP450. In this study, CPT11 alone or combined with dual-function inhibitor
Externí odkaz:
https://doaj.org/article/60fba43b184147e68b3468e03e99b7c1
Autor:
Yu-Hsuan Liu, Ling-Chun Chen, Wen-Ting Cheng, Pu-Sheng Wei, Chien-Ming Hsieh, Ming-Thau Sheu, Shyr-Yi Lin, Hsiu-O Ho, Hong-Liang Lin
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 473 (2023)
In recent years, combining different types of therapy has emerged as an advanced strategy for cancer treatment. In these combination therapies, oral delivery of anticancer drugs is more convenient and compliant. This study developed an irinotecan/rap
Externí odkaz:
https://doaj.org/article/00f9819882f5406098df3f61eed0e1a9
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 478 (2022)
Due to the increasing rate of drug resistance in Candida spp., higher doses of antifungal agents are being used resulting in toxicity. Drug delivery systems have been shown to provide an effective approach to enhance the efficacy and reduce the toxic
Externí odkaz:
https://doaj.org/article/f69d5ed6b79b4f33b99e3c205d150eb4
Autor:
Chia-En Chang, Chien-Ming Hsieh, Ling-Chun Chen, Chia-Yu Su, Der-Zen Liu, Hua-Jing Jhan, Hsiu-O Ho, Ming-Thau Sheu
Publikováno v:
Drug Delivery, Vol 25, Iss 1, Pp 632-643 (2018)
The synergistic combination of docetaxel (DTX) and cisplatin (CIS) by local drug delivery with a pluronic lecithin organogel (PLO) to facilitate high drug concentrations at tumor sites and less nonspecific distribution to normal organs is thought to
Externí odkaz:
https://doaj.org/article/efe77688b05d48be8190a9703af79528
Autor:
Athika Darumas Putri, Pai-Shan Chen, Yu-Lin Su, Jia-Pei Lin, Jing-Ping Liou, Chien-Ming Hsieh
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1728 (2021)
Histone deacetylase (HDAC) inhibitors have emerged as a new class of antitumor agent for various types of tumors. MPT0B291, a novel selective inhibitor of HDAC6, demonstrated significant antiproliferative activity in various human cancer cell types.
Externí odkaz:
https://doaj.org/article/7083347998ce4540aa8976983b0653e0
Autor:
Ritu Ojha, I-Chung Chen, Chien-Ming Hsieh, Kunal Nepali, Row-Wen Lai, Kai-Cheng Hsu, Tony Eight Lin, Shiow-Lin Pan, Mei-Chuan Chen, Jing-Ping Liou
Publikováno v:
Journal of Medicinal Chemistry. 64:17824-17845
Pragmatic insertion of pargyline, a LSD1 inhibitor, as a surface recognition part in the HDAC inhibitory pharmacophore was planned in pursuit of furnishing potent antiprostate cancer agents. Resultantly, compound