Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chien-Huan Weng"'
Autor:
Luis Felipe Campesato, Sadna Budhu, Jeremy Tchaicha, Chien-Huan Weng, Mathieu Gigoux, Ivan Jose Cohen, David Redmond, Levi Mangarin, Stephane Pourpe, Cailian Liu, Roberta Zappasodi, Dmitriy Zamarin, Jill Cavanaugh, Alfredo C. Castro, Mark G. Manfredi, Karen McGovern, Taha Merghoub, Jedd D. Wolchok
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The tryptophan metabolite kynurenine is an endogenous ligand of the aryl hydrocarbon receptor (AHR). Here, the authors show that AHR targeting in IDO/TDO-expressing tumours counteracts a regulatory T cell/macrophage suppressive axis and synergizes wi
Externí odkaz:
https://doaj.org/article/fdf441e3eec44fe9aa3a5806a8a6b86b
Autor:
Taha Merghoub, Roberta Zappasodi, Cailian Liu, Jedd Wolchok, Levi Mangarin, Pamela Holland, Chien-Huan Weng, David Schroder
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/6db3aa0bd16540348176b34c069f6441
Autor:
Chien-Huan Weng, Linda Hamadene, Shabnam Eghbali, Divya Venkatesh, Sébastien Monette, Levi Mangarin, Fadi Samaan, Cailian Liu, Pamela Holland, Jedd Wolchok, Taha Merghoub
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Jeremy Tchaicha, Mathieu Gigoux, Alfredo C. Castro, Levi Mangarin, Luis Felipe Campesato, Taha Merghoub, Jedd D. Wolchok, Dmitriy Zamarin, Cailian Liu, Karen McGovern, Ivan J. Cohen, Sadna Budhu, Jill Cavanaugh, Stephane Pourpe, David Redmond, Roberta Zappasodi, Chien-Huan Weng, Mark G. Manfredi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Tryptophan catabolism by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2 (IDO/TDO) promotes immunosuppression across different cancer types. The tryptophan metabolite L-Kynurenine (Kyn) interacts with the ligand-activated t
Publikováno v:
Nature reviews. Clinical oncology. 19(1)
The discovery and clinical implementation of immune-checkpoint inhibitors (ICIs) targeting CTLA4, PD-1 and PD-L1 has revolutionized the treatment of cancer, as recognized by the 2018 Nobel Prize for Medicine and Physiology. This groundbreaking new ap
Autor:
Chien-Huan Weng, Tseng-Hsi Lin, Ching-Heng Lin, Yu-Ting Lin, Yi-Huei Chen, Chien-Hsiang Weng, Abby L’Heureux
Publikováno v:
Pancreas. 50(4)
Autor:
Chien-Huan Weng, Fadi Samaan, Sadna Budhu, Levi Mangarin, Sébastien Monette, Cailian Liu, Stephane Pourpe, Linda Hamadene, Hong Zhong, Xia Yang, David Schroder, Roberta Zappasodi, Pamela Holland, Jedd D. Wolchok, Taha Merghoub
Publikováno v:
Cancer Research. 82:6150-6150
Multiple suppressive mechanisms within the tumor microenvironment (TME) are capable of blunting anti-tumor T cell responses. These include engagement of inhibitory receptors expressed in tumor-associated, exhausted CD8 T cells, such as programmed cel
Autor:
Levi Mangarin, Cailian Liu, Roberta Zappasodi, Pamela Holland, Jedd Wolchok, Taha Merghoub, Chien-Huan Weng, David Schroder
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Multiple suppressive mechanisms within the tumor microenvironment are capable of blunting anti-tumor T cell responses, including the engagement of inhibitory receptors expressed in tumor-associated, exhausted CD8+ T cells, such as programm
Autor:
Chien-Huan Weng, Abby L’Heureux, Tseng-Hsi Lin, Daniel R. Wieland, Yi-Huei Chen, Chien-Hsiang Weng, Ching-Heng Lin
Publikováno v:
JAMA Network Open
Key Points Question Are thyroid disorders associated with colorectal cancer risk in an East Asian population? Findings In this case-control study that included 139 426 adults in Taiwan with or without a diagnosis of primary colorectal cancer, both hy
Autor:
Uma Chandrasekaran, Chien-Huan Weng, Casey T. Weaver, Govind Bhagat, Eugenia G. Giannopoulou, Alessandra B. Pernis, Rolf Jessberger, Woelsung Yi, Sanjay Gupta, Yurii Chinenov
Publikováno v:
Arthritis & Rheumatology. 68:1454-1466
Objective Treg cells need to acquire an effector phenotype to function in settings of inflammation. Whether effector Treg cells can limit disease severity in lupus is unknown. Interferon regulatory factor 4 (IRF-4) is an essential controller of effec