Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Chien Liang Glenn Lin"'
Autor:
Zan Xu, Joshua Brian Foster, Rashelle Lashley, Xueqin Wang, Albert John Muhleman, Christopher Eli Masters, Chien-Liang Glenn Lin
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0309716 (2024)
Extracellular vesicles (EVs) play a crucial role in intercellular communication. Characterizing EV protein composition is essential to understand EV function(s). Isolating EVs from cell culture medium is a common approach to study EVs, but it remains
Externí odkaz:
https://doaj.org/article/f1a44859f63e4bd9b78fc65799ab0d19
Autor:
Zan Xu, Joshua B. Foster, Rashelle Lashley, Xueqin Wang, Emily Benson, Grahame Kidd, Chien-liang Glenn Lin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionWe previously discovered a pyridazine derivative compound series that can improve cognitive functions in mouse models of Alzheimer’s disease. One of the advanced compounds from this series, LDN/OSU-0215111-M3, was selected as the precli
Externí odkaz:
https://doaj.org/article/35750ae5a5f74f5e9ac22f471fdb6d6b
Autor:
Joshua B. Foster, Rashelle Lashley, Fangli Zhao, Xueqin Wang, Nydia Kung, Candice C. Askwith, Lin Lin, Michael W. Shultis, Kevin J. Hodgetts, Chien-Liang Glenn Lin
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-19 (2019)
Abstract Background The lack of effective treatment options for Alzheimer’s disease (AD) is of momentous societal concern. Synaptic loss is the hallmark of AD that correlates best with impaired memory and occurs early in the disease process, before
Externí odkaz:
https://doaj.org/article/8667be5d6cb241dcb817f7bf96dab56b
Autor:
Xueqin Wang, Zan Xu, Fangli Zhao, Kuanhung J. Lin, Joshua B. Foster, Tianqi Xiao, Nydia Kung, Candice C. Askwith, John P. Bruno, Valentina Valentini, Kevin J. Hodgetts, Chien-liang Glenn Lin
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100240- (2020)
Gulf War illness is associated with a combination of exposure to war-related chemical agents and traumatic stress. Currently, there are no effective treatments, and the pathophysiology remains elusive. Neurological problems are among the most commonl
Externí odkaz:
https://doaj.org/article/812793df0d1541d792d7a3180e11545f
Autor:
Qiongman Kong, Kou Takahashi, Delanie Schulte, Nathan Stouffer, Yuchen Lin, Chien-Liang Glenn Lin
Publikováno v:
Neurobiology of Disease, Vol 47, Iss 2, Pp 145-154 (2012)
Several lines of evidence indicate that glutamate plays a crucial role in the initiation of seizures and their propagation; abnormal glutamate release causes synchronous firing of large populations of neurons, leading to seizures. In the present stud
Externí odkaz:
https://doaj.org/article/3e4d15e6dff240d6b40f691a6b496143
Autor:
Kevin J. Hodgetts, Candice C. Askwith, Fang-li Zhao, Lin Lin, Nydia Kung, Chien-Liang Glenn Lin, Joshua B. Foster, Michael W. Shultis, Rashelle Lashley, Xueqin Wang
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-19 (2019)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background The lack of effective treatment options for Alzheimer’s disease (AD) is of momentous societal concern. Synaptic loss is the hallmark of AD that correlates best with impaired memory and occurs early in the disease process, before the onse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d2cb6c24507b8a183c267eda2b9311
http://link.springer.com/article/10.1186/s13195-019-0530-z
http://link.springer.com/article/10.1186/s13195-019-0530-z
Autor:
Yueming Chang, Qiongman Kong, Xiu Shan, Guilian Tian, Hristelina Ilieva, Don W Cleveland, Jeffrey D Rothstein, David R Borchelt, Philip C Wong, Chien-Liang Glenn Lin
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2849 (2008)
Accumulating evidence indicates that RNA oxidation is involved in a wide variety of neurological diseases and may be associated with neuronal deterioration during the process of neurodegeneration. However, previous studies were done in postmortem tis
Externí odkaz:
https://doaj.org/article/47b90d31b49b48ce8d3e00e9b55febff
Autor:
Chien-Liang Glenn Lin, Xueqin Wang, Kuanhung J. Lin, Zan Xu, Valentina Valentini, John P. Bruno, Nydia Kung, Candice C. Askwith, Tianqi Xiao, Kevin J. Hodgetts, Joshua B. Foster, Fang-li Zhao
Publikováno v:
Neurobiology of Stress, Vol 13, Iss, Pp 100240-(2020)
Neurobiology of Stress
Neurobiology of Stress
Gulf War illness is associated with a combination of exposure to war-related chemical agents and traumatic stress. Currently, there are no effective treatments, and the pathophysiology remains elusive. Neurological problems are among the most commonl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65e6496f391c2ccbd12319e97d5d3b9
https://doi.org/10.1016/j.ynstr.2020.100240
https://doi.org/10.1016/j.ynstr.2020.100240
Autor:
Qiongman Kong, Kevin J. Hodgetts, Marcie A. Glicksman, Sky Dominguez, Xuechao Xing, Kou Takahashi, Gregory D. Cuny, Ling-Chu Chang, Nathan Stouffer, Liching Lai, Qibing Liu, Chien-Liang Glenn Lin, Delanie A. Schulte, Yuchen Lin
Publikováno v:
The Journal of Experimental Medicine
Takahashi et al. demonstrate that restoring glial glutamate transporter EAAT2 function improves cognitive functions and synaptic integrity while reducing amyloid plaques in a sustained fashion after treatment cessation.
Glutamatergic systems pla
Glutamatergic systems pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0180b4243cdf6b04dd085cf6f361cf39
https://doi.org/10.1084/jem.20140413
https://doi.org/10.1084/jem.20140413
Autor:
Delanie A. Schulte, Kou Takahashi, Yuchen Lin, Qiongman Kong, Nathan Stouffer, Chien-Liang Glenn Lin
Publikováno v:
Neurobiology of Disease, Vol 47, Iss 2, Pp 145-154 (2012)
Several lines of evidence indicate that glutamate plays a crucial role in the initiation of seizures and their propagation; abnormal glutamate release causes synchronous firing of large populations of neurons, leading to seizures. In the present stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a24d27bccca31eec6d01bf9534a7195
http://www.sciencedirect.com/science/article/pii/S0969996112001210
http://www.sciencedirect.com/science/article/pii/S0969996112001210