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Akademický článek
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Publikováno v:
Nucleic Acids Research
TDP-43 is an important pathological protein that aggregates in the diseased neuronal cells and is linked to various neurodegenerative disorders. In normal cells, TDP-43 is primarily an RNA-binding protein; however, how the dimeric TDP-43 binds RNA vi
Autor:
James C.K. Shen, Pan Hsien Kuo, Yi Ting Wang, Yun-Ru Chen, Chien Hao Chiang, Shuying Wang, Hanna S. Yuan, Jhe Ruei Liang
Publikováno v:
The Journal of Biological Chemistry
Background: TDP-43 forms aggregates in various neurodegenerative disorders. Results: The C-terminal-truncated RRM2 of TDP-43 forms non-amyloid fibrils in vitro and plays a dominant role in forming inclusions in vivo. Conclusion: The proteolytic cleav
Autor:
Pan Hsien Kuo, Che Kun James Shen, Cédric Grauffel, Chien Hao Chiang, Carmay Lim, Hanna S. Yuan, Lien Szu Wu, Lyudmila G. Doudeva
Publikováno v:
Scientific Reports
Scientific reports, vol 6, iss 1
Scientific reports, vol 6, iss 1
The RNA-binding protein TDP-43 forms intracellular inclusions in amyotrophic lateral sclerosis (ALS). While TDP-43 mutations have been identified in ALS patients, how these mutations are linked to ALS remains unclear. Here we examined the biophysical
Autor:
Chien-hao Chiang, 江健豪
97
This study was designed to investigate the different types of feedback on written assessment given by Taiwanese junior high school teachers, as well as the quality and validity of this feedback. Current conceptualizations of how to construct
This study was designed to investigate the different types of feedback on written assessment given by Taiwanese junior high school teachers, as well as the quality and validity of this feedback. Current conceptualizations of how to construct
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/rnvz75
Autor:
Chien-hao Chiang, 江健豪
94
For the ancient Greeks, ritual, a religious and sacred activity, is performed for harvest, safe journey, appeasing gods and so on. Ritual is about communication, demonstration and reciprocation. Firstly, communication: ritual tries to communi
For the ancient Greeks, ritual, a religious and sacred activity, is performed for harvest, safe journey, appeasing gods and so on. Ritual is about communication, demonstration and reciprocation. Firstly, communication: ritual tries to communi
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/26464915862183394699
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C217-C217
TDP-43 is an RNA-binding protein with multiple function in the regulation of mRNA splicing and translation. However in diseased neuronal cells, TDP-43 forms aggregates and is linked to various neurodegenerative disorders, including amyotrophic latera
Akademický článek
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Autor:
Yi-Ting Wang1, Pan-Hsien Kuo1, Chien-Hao Chiang1,2, Jhe-Ruei Liang1,3, Yun-Ru Chen4, Shuying Wang5,6, Shen, James C. K.1, Yuan, Hanna S.1,7 hanna@sinica.edu.tw
Publikováno v:
Journal of Biological Chemistry. 3/29/2013, Vol. 288 Issue 13, p9049-9057. 9p.