Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions

Autor: Zaufel, Alex, van de Wiel, Sandra M.W., Yin, Lu, Fauler, Günter, Chien, Daphne, Dong, Xinzhong, Gilmer, John F., Truong, Jennifer K., Dawson, Paul A., van de Graaf, Stan F.J., Fickert, Peter, Moustafa, Tarek

Publikováno v: In BBA - Molecular Basis of Disease 1 August 2021 1867(8)

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Molecular Display of the Animal Meta-Venome for Discovery of Novel Therapeutic Peptides.

Autor: Hsiao MH; Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; These authors contributed equally to this work., Miao Y; Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; These authors contributed equally to this work., Liu Z; Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Biology, Zanvyl Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, USA., Schütze K; School of Biological Sciences, Seoul National University, Seoul, South Korea., Limjunyawong N; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Center of Research Excellence in Allergy and Immunology, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand., Chien DC; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Monteiro WD; Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Chu LS; Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Morgenlander W; Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Jayaraman S; Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Jang SE; School of Biological Sciences, Seoul National University, Seoul, South Korea., Gray JJ; Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Zhu H; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Viral Oncology Program, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Dong X; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Steinegger M; School of Biological Sciences, Seoul National University, Seoul, South Korea.; Artificial Intelligence Institute, Seoul National University, Seoul, South Korea.; Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea., Larman HB; Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 28. Date of Electronic Publication: 2024 May 28.