Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Chieko Hashizume"'
Autor:
Masateru Nomura, Joseph George, Chieko Hashizume, Takashi Saito, Yoshimichi Ueda, Yasuhito Ishigaki, Mutsumi Tsuchishima, Mikihiro Tsutsumi
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-18 (2022)
Abstract Background Mesenchymal stem cells (MSCs) are multipotent stromal cells and could exert hepatoprotective effects against acute liver injury, steatohepatitis, and fibrogenesis. Here, we evaluated the effects of human adipose derived stem cells
Externí odkaz:
https://doaj.org/article/9f816651cb0443af953d309389b41196
Publikováno v:
Molecular Medicine, Vol 25, Iss 1, Pp 1-13 (2019)
Abstract Background There are two isoforms of sphingomyelin synthase (SMS): SMS1 and SMS2. SMS1 is located in the Golgi apparatus only while SMS2 is located in both the plasma membrane and the Golgi apparatus. SMS1 and SMS2 act similarly to generate
Externí odkaz:
https://doaj.org/article/b894456745fd4dfb91d40a8854be0958
Novel PKD2 Missense Mutation p.Ile424Ser in an Individual with Multiple Hepatic Cysts: A Case Report
Autor:
Seiko Miura, Yo Niida, Chieko Hashizume, Ai Fujii, Yuta Takagaki, Kahoru Kusama, Sumiyo Akazawa, Tetsuya Minami, Tsuyoshi Mukai, Kengo Furuichi, Mutsumi Tsuchishima, Nobuhiko Ueda, Hiroyuki Takamura, Daisuke Koya, Tohru Ito
Publikováno v:
Medicines, Vol 9, Iss 4, p 25 (2022)
We report a novel missense mutation, p.Ile424Ser, in the PKD2 gene of an autosomal dominant polycystic kidney disease (ADPKD) patient with multiple liver cysts. A 57-year-old woman presented to our university hospital with abdominal fullness, decreas
Externí odkaz:
https://doaj.org/article/53bc3d2979f943a3aed29a2c47fc9887
Autor:
Jun Fujita, Makoto Taniguchi, Chieko Hashizume, Yoshibumi Ueda, Shota Sakai, Tadakazu Kondo, Mayumi Hashimoto-Nishimura, Kentaro Hanada, Takeo Kosaka, Toshiro Okazaki
Publikováno v:
Molecular Pharmacology. 101:322-333
Ceramide is a bioactive sphingolipid that mediates ionizing radiation- and chemotherapy-induced apoptosis. Neocarzinostatin (NCS) is a genotoxic anti-cancer drug that induces apoptosis in response to DNA double-strand breaks (DSBs) through ataxia tel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb8efda6bf7847b85d1cda7d87f5f30
https://doi.org/10.1124/molpharm.121.000379
https://doi.org/10.1124/molpharm.121.000379
Autor:
Kenta Arai, Ken Watanabe, Makoto Taniguchi, Kazuhiko Hayashi, Yoshibumi Ueda, Koichi Fukase, Toshiro Okazaki, Shingo Nagaya, Chieko Hashizume, Kazuya Kabayama, Lusi Oka Wardhani, Michiko Matsushita
Publikováno v:
The FASEB Journal. 34:3838-3854
The tumor microenvironment (TME) formation involving host cells and cancer cells through cell adhesion molecules (CAMs) is essential for the multiple steps of cancer metastasis and growth. Sphingomyelin synthase 2 (SMS2) is involved in inflammatory d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b527825d20c02aaf56adfa37c1f2d5c5
https://doi.org/10.1096/fj.201901783rr
https://doi.org/10.1096/fj.201901783rr
Autor:
Makoto Taniguchi, Yoshibumi Ueda, Yoritaka Fujii, Toshiro Okazaki, Chieko Hashizume, Ken Watanabe, Takeo Kosaka, Hiroyuki Takeya, Shingo Nagaya
Publikováno v:
Blood advances. 5(20)
Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. Here, we describe the hematologic phenotypes, such as reduced circulating platelets and dysfunctional hemost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee80677be84400fe5b61719dee1e7cdc
https://pubmed.ncbi.nlm.nih.gov/34478523
https://pubmed.ncbi.nlm.nih.gov/34478523
Publikováno v:
Molecular Medicine
Molecular Medicine, Vol 25, Iss 1, Pp 1-13 (2019)
Molecular Medicine, Vol 25, Iss 1, Pp 1-13 (2019)
BackgroundThere are two isoforms of sphingomyelin synthase (SMS): SMS1 and SMS2. SMS1 is located in the Golgi apparatus only while SMS2 is located in both the plasma membrane and the Golgi apparatus. SMS1 and SMS2 act similarly to generate sphingomye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c6fe6b46330e17d0678711b0889e0a
http://europepmc.org/articles/PMC6918654
http://europepmc.org/articles/PMC6918654
Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis‐associated colon cancer
Autor:
Makoto Taniguchi, Toshiro Okazaki, Chieko Hashizume, Takeo Kosaka, Toshio Ohnishi, Hidehiro Furumoto, Shinichi Kinami, Rongfen Gao, Jia Han
Publikováno v:
The FASEB Journal. 31:3816-3830
Sphingomyelin synthase 2 (SMS2) is the synthetic enzyme of sphingomyelin (SM), which regulates membrane fluidity and microdomain structure. SMS2 plays a role in LPS-induced lung injury and inflammation; however, its role in inflammation-mediated tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0892fd1ecc95c495f10b897a3ac2baf0
https://doi.org/10.1096/fj.201601225rr
https://doi.org/10.1096/fj.201601225rr
Publikováno v:
Seikagaku. The Journal of Japanese Biochemical Society. 88(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e3ed09e9c24f167b8781e4560dc159d
https://pubmed.ncbi.nlm.nih.gov/29624348
https://pubmed.ncbi.nlm.nih.gov/29624348
Publikováno v:
Cell Cycle
Centrosomes are comprised of 2 orthogonally arranged centrioles surrounded by the pericentriolar material (PCM), which serves as the main microtubule organizing center of the animal cell. More importantly, centrosomes also control spindle polarity an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98049ee8847c44ebeccac995c649c792
https://doi.org/10.4161/cc.26671
https://doi.org/10.4161/cc.26671