Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Chieh-Ju C. Tang"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Mutations in many centriolar protein-encoding genes cause primary microcephaly. Here the authors show that human microcephaly protein RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building
Externí odkaz:
https://doaj.org/article/17908d7c695d4446b67c1c19166df732
Autor:
En-Ju Chou, Liang-Yi Hung, Chieh-Ju C. Tang, Wen-Bin Hsu, Hsin-Yi Wu, Pao-Chi Liao, Tang K. Tang
Publikováno v:
Cell Reports, Vol 14, Iss 12, Pp 2975-2987 (2016)
CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that CPAP maintains spindle pole integrity through its phosphorylation by Aurora-A during mitosis. Depletion of CPA
Externí odkaz:
https://doaj.org/article/1bb22a2249ab43efa6ec85328495d44f
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
The meiotic generation of haploid gametes with equal contents of genetic material is important for sexual reproduction in mammals. Errors in the transmission of chromosomes during meiosis may lead to aneuploidy, which is the leading cause of miscarri
Externí odkaz:
https://doaj.org/article/de359b5c75ad4b11bf29cb671ccd4d77
Publikováno v:
Journal of Biomedical Science. Mar2005, Vol. 12 Issue 2, p297-310. 14p. 3 Color Photographs, 3 Graphs.
Publikováno v:
Journal of Biomedical Science. May/Jun2004, Vol. 11 Issue 3, p370-376. 7p. 3 Black and White Photographs, 1 Graph.
Autor:
Yi-Nan Lin, Tang K. Tang, Ching-Wen Chang, En-Ju Chou, Chieh-Ju C. Tang, Wen-Bin Hsu, Yu-Chih Lin, Chien-Ting Wu
Publikováno v:
The EMBO Journal. 32:1141-1154
Centrioles are cylindrical structures that are usually composed of nine triplets of microtubules (MTs) organized around a cartwheel-shaped structure. Recent studies have proposed a structural model of the SAS-6-based cartwheel, yet we do not know the
Autor:
Tang K. Tang, Yi-Nan Lin, Ching-Wen Chang, Chien-Ting Wu, Yu-Chih Lin, Chieh-Ju C. Tang, Wen-Bin Hsu
Publikováno v:
The Journal of Cell Biology
CEP120 cooperates with CPAP to promote centriole elongation in a cell cycle– and microtubule-dependent manner.
Centriole duplication begins with the formation of a single procentriole next to a preexisting centriole. CPAP (centrosomal protein
Centriole duplication begins with the formation of a single procentriole next to a preexisting centriole. CPAP (centrosomal protein
Publikováno v:
Journal of Cell Science
Centriole duplication is a tightly ordered process during which procentrioles are assembled in G1-S and elongate during S and G2. Here, we show that human CEP295 (Drosophila Ana1) is not essential for initial cartwheel assembly, but is required to bu
Autor:
Yu-Chih Lin, Chieh-Ju C. Tang, Chien-Ting Wu, Kuo-Sheng Wu, Shin-Yi Lin, Ching-Wen Chang, Yi-Nan Lin, Tang K. Tang, Wen-Bin Hsu
Publikováno v:
The EMBO Journal. 30:4790-4804
Centriole duplication involves the growth of a procentriole next to the parental centriole. Mutations in STIL and CPAP/CENPJ cause primary microcephaly (MCPH). Here, we show that human STIL has an asymmetric localization to the daughter centriole and
Autor:
Yi-Nan Lin, Sheng-Chung Lee, Chih-Chieh Chang, Kuo-Tai Yang, Tang K. Tang, Shu-Kuei Li, Chieh-Ju C. Tang
Publikováno v:
Molecular Biology of the Cell
We report for the first time the subcellular localization of endogenous Aurora-C and examine its roles during female mouse meiosis. The most dramatic effect observed in the oocyte injected with kinase-deficient Aurora-C mRNA is cytokinesis failure in