Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Chie Otsuka"'
Autor:
Makiko Suzuki, Kaeko Murota, Chie Otsuka, Yoshitaka Takahashi, Miyuki Yokoro, Masumi Kimoto, Hideaki Tsuji, Hiromi Yamashita
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 76:1334-1342
N(G), N(G)-Dimethyl-L-arginine (asymmetric dimethylarginine: ADMA) is an endogenous competitive inhibitor of nitric oxide synthase (NOS). Plasma ADMA concentrations have been reported to increase in connection with diseases associated with an impaire
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 74:2463-2469
Rice has evolved metabolic and morphological adaptations to low-oxygen stress to grow in submerged paddy fields. To characterize the molecular components that mediate the response to hypoxia in rice, we identified low-oxygen stress early response gen
Autor:
Tomoe Negishi, Chie Otsuka, Keinosuke Okamoto, Yoji Okugawa, Kazuo Negishi, David Loakes, Sakae Arimoto, Chin Wei Yung
Publikováno v:
Mutagenesis. 23:509-513
We have analysed the influence of neighbouring base sequences on the mutagenesis induced by 7,8-dihydro-8-oxoguanine (8-oxoG or G(o)), a typical oxidative lesion of DNA, using the yeast oligonucleotide transformation technique. Two oligonucleotides,
Publikováno v:
Nucleic Acids Research
We have studied the mutagenic properties of ribonucleotide analogues by reverse transcription to understand their potential as antiretroviral agents by mutagenesis of the viral genome. The templating properties of nucleotide analogues including 6-(be
Autor:
Shoichi Higashi, Chie Otsuka, Kazuo Negishi, Takanori Nakamura, Tomoe Negishi, Masakatsu Watanabe
Publikováno v:
Genes and Environment. 28:74-76
Publikováno v:
Nucleic acids symposium series (2004). (49)
Pyrimidine analogues, N4-hydroxycytosine (C(oh)), N4-methoxycytosine (C(mo)) and 6H, 8H-3,4-dihydropyrimido[4,5-c][1,2]oxazin-7-one (P) can form base pairs with both adenine and guanine. We examined the mutagenic properties of these ribonucleotide an
Autor:
Chie Otsuka, Hiroshi Omote, Tomofusa Tsuchiya, Makoto Yasuda, Yoshinori Moriyama, Masato Otsuka, Yuji Morita
Publikováno v:
Journal of bacteriology. 187(5)
NorM is a member of the multidrug and toxic compound extrusion (MATE) family and functions as a Na + /multidrug antiporter in Vibrio parahaemolyticus , although the underlying mechanism of the Na + /multidrug antiport is unknown. Acidic amino acid re
Publikováno v:
Mutation research. 578(1-2)
Rev1p in yeast is essential for the translesion of abasic sites and 6-4 photoproducts. It plays a role as a translesion polymerase, but also supports translesion catalyzed by other polymerases. The protein has two domains, BRCT and Y-family polymeras
Publikováno v:
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs. 6(2)
Blood cells are subject to various kinds of stresses in flow fields. Hemolysis is the phenomenon in which a higher stress than normal damages the erythrocyte membrane and results in the leakage of its contents. Even if the stress is not strong enough
Autor:
Hisanori Okuto, Yasuhiro Hata, Sachi Sanadai, Vladimir N. Noskov, Kazuo Negishi, David Loakes, Chie Otsuka
Publikováno v:
Nucleic acids research. 30(23)
We have analyzed the mutagenic specificity of an abasic site in DNA using the yeast oligonucleotide transformation assay. Oligonucleotides containing an abasic site or its analog were introduced into B7528 or its derivatives, and nucleotide incorpora