Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Chie Oshita"'
Autor:
Akiko Kume, Takashi Sugino, Tadashi Ashizawa, Koichi Mitsuya, Ken Yamaguchi, Haruo Miyata, Maho Omiya, Akira Iizuka, Yasuto Akiyama, Yoko Nakasu, Chie Oshita, Masaru Komiyama, Nakamasa Hayashi
Publikováno v:
Oncology Reports. 32:159-166
The frequent recurrence of glioblastoma multiforme (GBM) after standard treatment with temozolomide (TMZ) is a crucial issue to be solved in the clinical field. O6‑methylguanine‑DNA methyltransferase (MGMT) is considered one of the major mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0bdff6132cad8ed4801fbe307a28529
https://doi.org/10.3892/or.2014.3195
https://doi.org/10.3892/or.2014.3195
Autor:
Chie Oshita, Akiko Kume, Masaru Komiyama, Ken Yamaguchi, Koichi Mitsuya, Tadashi Ashizawa, Yoko Nakasu, Yasuto Akiyama, Akira Iizuka, Nakamasa Hayashi
Publikováno v:
Immunology Letters. 159:15-22
Antibody direct cloning from single B cells is simple and efficient and has been successful in antibody identification of infectious diseases. However, although a recent whole-exome sequencing revealed abundant heterogeneic mutation accumulation in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb6b7a4a4fdb60fd7a3a19b8c04b5d1
https://doi.org/10.1016/j.imlet.2014.02.004
https://doi.org/10.1016/j.imlet.2014.02.004
Autor:
Koichi Mitsuya, Haruo Miyata, Chie Oshita, Masahiro Nogami, Nakamasa Hayashi, Akira Iizuka, Yoko Nakasu, Reiko Watanabe, Yasuto Akiyama, Ken Yamaguchi, Mika Yagoto, Ichiro Ito, Akiko Kume, Tadashi Ashizawa, Masaru Komiyama, Takashi Sugino
Publikováno v:
Oncology Reports. 31:1683-1690
Glioblastoma multiforme (GBM) is one of the most malignant and aggressive tumors, and has a very poor prognosis with a mean survival time of2 years, despite intensive treatment using chemo-radiation. Therefore, novel therapeutic approaches including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224688834cca97251c50f870b8ad1eb4
https://doi.org/10.3892/or.2014.3049
https://doi.org/10.3892/or.2014.3049
Autor:
Toshio Furuya, Akira Asai, Masami Otsuka, Masaru Komiyama, Mika Yagoto, Haruo Miyata, Koichi Mitsuya, Ken Yamaguchi, Yoko Nakasu, Chie Oshita, Kenji Matsuno, Akiko Kume, Tadashi Okawara, Akira Iizuka, Yasuto Akiyama, Reiko Watanabe, Takuma Oishi, Masahiro Nogami, Naohisa Ogo, Ichiro Ito, Tadashi Ashizawa
Publikováno v:
International Journal of Oncology. 43:219-227
Signal transducer and activator of transcription (STAT) 3, a member of a family of DNA-binding molecules, is a potential target in the treatment of cancer. The highly phosphorylated STAT3 in cancer cells contributes to numerous physiological and onco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41eb03424cbe98100a5ab8433e59463b
https://doi.org/10.3892/ijo.2013.1916
https://doi.org/10.3892/ijo.2013.1916
Autor:
Ryuji Tanosaki, Masako Takikawa, Kazutoh Takesako, Chie Oshita, Naoya Yamazaki, Ken Yamaguchi, Akifumi Yamamoto, Yoshio Kiyohara, Akiko Kume, Yasuto Akiyama, Haruo Miyata, Tadashi Ashizawa, Akira Iizuka, Shusuke Yoshikawa
Publikováno v:
Oncology Reports
Metastatic and chemoresistant melanoma can be a good target of immunotherapy because it is an intractable cancer with a very poor prognosis. Previously, we tested a dendritic cell (DC)-based phase I vaccine, and confirmed that it was safe. In the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5789fbbc2044a0e101037f62065b0ed1
http://europepmc.org/articles/PMC3583475
http://europepmc.org/articles/PMC3583475
Autor:
Akira Asai, Takane Yokotagawa, Sachiko Tai, Osamu Takahashi, Tadashi Okawara, Hiroshi Sato, Ayumu Muroya, Yasuto Akiyama, Chie Oshita, Masami Otsuka, Yoshiaki Masuda, Tadashi Ashizawa, Yutaka Uehara, Kenji Matsuno, Hidee Ishii, Toshio Furuya, Naohisa Ogo
Publikováno v:
ACS Medicinal Chemistry Letters. 1:371-375
The signal transducer and activator of transcription 3 (STAT3) is considered to be an attractive therapeutic target for oncology drug development. We identified a N-[2-(1,3,4-oxadiazolyl)]-4-quinolinecarboxamide derivative, STX-0119, as a novel STAT3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd699a3088b69c9cd94c74b7f57b9a32
https://doi.org/10.1021/ml1000273
https://doi.org/10.1021/ml1000273
Autor:
Akiko Kume, Chie Oshita, Masahiro Nogami, Tadashi Ashizawa, Haruo Miyata, Tohru Mochizuki, Masaru Komiyama, Kazumichi Ozawa, Ken Yamaguchi, Yasuto Akiyama, Naoki Sakura
Publikováno v:
Biomedical research (Tokyo, Japan). 35(2)
Of all potential biological therapeutics, monoclonal antibody (mAb)-based therapies are becoming the dominant focus of clinical research. In particular, smaller recombinant antibody fragments such as single-chain variable fragments (scFv) have become
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ef831f960c9e0f9c34a110c2931df0
https://pubmed.ncbi.nlm.nih.gov/24759178
https://pubmed.ncbi.nlm.nih.gov/24759178
Autor:
Haruo Miyata, Akiko Kume, Yoshio Kiyohara, Masaru Komiyama, Tadashi Ashizawa, Chie Oshita, Akira Iizuka, Yasuto Akiyama, Yoji Nakamura, Masahiro Nogami, Shusuke Yoshikawa, Ken Yamaguchi
Publikováno v:
Cancer immunology, immunotherapy : CII. 61(12)
Many cancer-testis antigen genes have been identified; however, few human leukocyte antigen (HLA)-A24-restricted cytotoxic T cell (CTL) epitope peptides are available for clinical immunotherapy. To solve this problem, novel tools increasing the effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc6af5db62765906f21d7ac36554060
https://pubmed.ncbi.nlm.nih.gov/22707303
https://pubmed.ncbi.nlm.nih.gov/22707303
Autor:
Toshio Furuya, Naohisa Ogo, Chie Oshita, Haruo Miyata, Yoshiaki Masuda, Akira Asai, Masami Otsuka, Tadashi Okawara, Hidee Ishii, Tadashi Ashizawa, Kenji Matsuno, Yasuto Akiyama
Publikováno v:
International journal of oncology. 38(5)
Signal transducer and activator of transcription (STAT)3, a member of a family of DNA-binding molecules mediating numerous physiological and oncogenic signaling pathways, is a novel target in cancer cells which show high phosphorylation of STAT3. Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19a333508e96a5c1675d62d6b4f212e
https://pubmed.ncbi.nlm.nih.gov/21369699
https://pubmed.ncbi.nlm.nih.gov/21369699
Autor:
Tadashi Ashizawa, Sachiko Tai, Shuji Saito, Akira Iizuka, Haruhiko Kondo, Shigeki Yamaguchi, Ken Yamaguchi, Chie Oshita, Yoji Nakamura, Yasuto Akiyama
Publikováno v:
Cancer Science. 102:apr cover-apr cover
Carcinoembryonic antigen (CEA) is a very common tumor marker because many types of solid cancer usually produce a variety of CEA and a highly sensitive measuring kit has been developed. However, immunological responses associated with CEA have not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581bb54a54d6cc2a5a11c5ead241f6f9
https://doi.org/10.1111/j.1349-7006.2011.01882.x
https://doi.org/10.1111/j.1349-7006.2011.01882.x