Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Chie Makino"'
Autor:
Chie, Makino, Akiko, Watanabe, Manabu, Kato, Hideyuki, Shiozawa, Hideo, Takakusa, Daisuke, Nakai, Tomoyo, Honda, Nobuaki, Watanabe
Publikováno v:
Drug metabolism and pharmacokinetics. 45
Our previous study in rats demonstrated that the metabolic pathways of DS-8500a, a novel GPR119 agonist, include cleavage pathways: reductive cleavage of the oxadiazole ring in the liver and hydrolysis of the amide side chain. In the present study, i
Autor:
Chie Makino, Akiko Watanabe, Manabu Kato, Hideyuki Shiozawa, Hideo Takakusa, Daisuke Nakai, Tomoyo Honda, Nobuaki Watanabe
Publikováno v:
Drug Metabolism and Pharmacokinetics. 45:100459
Autor:
Veronika Rozehnal, Ilona Schreck, Osamu Ando, Tsuneo Deguchi, Chie Makino, Hiroshi Yamazaki, Nobuaki Watanabe, Hideyuki Shiozawa, Akiko Watanabe, Tomoko Ishizuka, Norie Murayama
A 1,2,4-oxadiazole ring-containing compound DS-8500a was developed as a novel G protein-coupled receptor 119 agonist. In vivo metabolic fates of [14C]DS-8500a differently radiolabeled in the benzene ring or benzamide side carbon in rats were investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8f1ae2301ed630b4a364b1d890d9ea
Publikováno v:
Bioanalysis. 4:263-269
Background: Drug-induced toxicity such as idiosyncratic drug toxicity is believed to be reduced when either reactive metabolite formation or exposure to a drug is minimized. The objective of the present study was therefore to clarify the relationship
Publikováno v:
Drug Metabolism and Pharmacokinetics. 24:100-107
The metabolic bioactivation of a drug to a reactive metabolite (RM) and its covalent binding to cellular macromolecules is believed to be involved in clinical adverse events, including idiosyncratic drug toxicities. Therefore, it is important to asse
Autor:
Hideo Takakusa, Hideo Yukinaga, Osamu Okazaki, Hiroshi Masumoto, Shintaro Nakayama, Chie Makino, Kenichi Sudo
Publikováno v:
Drug Metabolism and Disposition. 36:1770-1779
Bioactivation of a drug to a reactive metabolite and its covalent binding to cellular macromolecules is believed to be involved in clinical adverse events, including idiosyncratic drug toxicities (IDTs). For the interpretation of the covalent binding
Publikováno v:
Chemical research in toxicology. 20(3)
The covalent binding of reactive intermediates to macromolecules might have potential involvement in severe adverse drug reactions. Thus, quantification of reactive metabolites is necessary during the early stage of drug discovery to avoid serious to
Publikováno v:
Journal of nutritional science and vitaminology. 38(4)
We studied the effects of oligosaccharides which were obtained from tamarind xyloglucan by cellulase digestion on absorption of 3-O-methyl-D-glucose using the everted sacs from rat small intestine. Among oligosaccharides tested, octasaccharide and no