Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Chie Kadowaki"'
Autor:
Chie Kadowaki, Yoshinori Kohmura, Donald R. Gauthier, Kazunobu Igawa, David A. Conlon, Shinji Kato, Shigemitsu Okada, Anthony O. King, Yong-Li Zhong, Brenda Pipik, Akihiro Takezawa, Robert A. Reamer, Jaemoon Lee, Hua Zhou, David Askin
Publikováno v:
Organic Process Research & Development. 12:1245-1252
A practical and efficient synthesis of the potent HIV integrase inhibitor 1 is described. Starting from readily available 3,4-dihydro-2H-pyran, the six-step synthesis features a through process without purification of any of the intermediates until t
Autor:
Benjamin Marcune, Sandor Karady, Ross A. Miller, Stan S. Hall, Toshiaki Mase, Kenneth J. Fitch, Kenji Maeda, Satoshi Kii, J. J. Dannenberg, Chie Kadowaki, David M. Tschaen, Robert A. Reamer, Kenichi Asakawa
Publikováno v:
Tetrahedron Letters. 46:5081-5084
2-Lithio benzimidazoles were acylated with esters, lactones, and lactams. The tetrahedral hemiacetal intermediates responsible for the efficient conversion were characterized by low temperature NMR.
Autor:
Chie Kadowaki, Isao Kadota, Stephan Thorand, Philip Wai Hong Chan, Yoshinori Yamamoto, Kumi Sato, Choul Hong Park, Hiroyoshi Takamura
Publikováno v:
Tetrahedron. 58:1799-1816
Stereocontrolled syntheses of the AB and EFGH ring systems of gambierol ( 1 ) are described. The two key intermediates 3 and 55 , representing the AB and EFGH ring frameworks, were prepared from 2-deoxy- d -ribose via linear sequences. Brown's asymme
Publikováno v:
Tetrahedron Letters. 42:6199-6202
Publikováno v:
Tetrahedron Letters. 41:5769-5772
A new strategy for the convergent assembly of six-membered polycyclic ether ring fragments has been developed based upon the novel reaction between vinylstannanes with triflates in the presence of a strong base. The application of the present method
Publikováno v:
Tetrahedron Letters. 39:6369-6372
Stereoselective synthesis of the H ring of gambierol was achieved from 2-deoxy-D-ribose by using the intramolecular reaction of allylstannane with aldehyde as a key step. Modified Stille coupling was successfully applied for the construction of the t
Publikováno v:
Tetrahedron Letters. 42:6195-6197
The EFGH ring segment of gambierol was synthesized from 2-deoxy- d -ribose in 40 steps. The present synthesis includes a SmI 2 -mediated reductive cyclization and a Pd-catalyzed coupling of enol triflate with a zinc bis-homoenolate as key steps.
Autor:
Chie Kadowaki, Shinichi Saito, Yoshinori Yamamoto, Isao Kadota, Vladimir Gevorgyan, Matthew M. Salter
Publikováno v:
ChemInform. 28
Palladium catalyzed addition of certain carbon pronucleophiles 2 to conjugated enynes 1 afforded the corresponding allenes 3 in good to excellent yields. The most reactive methynes such as methylmalononitrile 2c enabled to undergo double addition lea
Publikováno v:
ChemInform. 29
Stereoselective synthesis of the H ring of gambierol was achieved from 2-deoxy-D-ribose by using the intramolecular reaction of allylstannane with aldehyde as a key step. Modified Stille coupling was successfully applied for the construction of the t
Publikováno v:
ChemInform. 33
The EFGH ring segment of gambierol was synthesized from 2-deoxy- d -ribose in 40 steps. The present synthesis includes a SmI 2 -mediated reductive cyclization and a Pd-catalyzed coupling of enol triflate with a zinc bis-homoenolate as key steps.