Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Chie Fujiwara"'
2
Discovery of a Novel Class of State-Dependent NaV1.7 Inhibitors for the Treatment of Neuropathic Pain
Autor: Yutaka Kitano, Chie Fujiwara, Sayaka Suzuki, Ryuta Koishi, Tomihisa Yokoyama, Satoshi Shibuya, Daigo Asano, Yuki Domon, Kyosuke Tanaka, Hiroko Kimoto, Akiko Shimizugawa, Tsuyoshi Shinozuka, Kazufumi Kubota, Hiroyuki Kobayashi
Publikováno v: Chemical and Pharmaceutical Bulletin. 68:653-663
The discovery of a novel class of state-dependent voltage-gated sodium channel (NaV)1.7 inhibitors is described. By the modification of amide or urethane bond in NaV1.7 blocker III, structure-activity relationship studies that led to the identificati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89845e45af2cb38ea79da89f3f6a10c8
https://doi.org/10.1248/cpb.c20-00126
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3
Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor
Autor: Tomihisa Yokoyama, Sakiko Takahashi, Kiyoshi Takasuna, Noriyuki Hayashi, Hiroyuki Kobayashi, Ryuta Koishi, Chie Fujiwara, Eri Tokumaru, Yasuyuki Abe, Kyosuke Tanaka, Sayaka Suzuki, Kazufumi Kubota, Daigo Asano, Narayan Karanjule, Tsuyoshi Shinozuka, Masahiro Inoue, Hiroko Kimoto, Tsuda Toshifumi, Yutaka Kitano, Kiyono Ueda, Toshiyuki Watanabe, Yuki Domon, Tomoko Sakakura, Akiko Shimizugawa
Publikováno v: Journal of Medicinal Chemistry. 63:10204-10220
A highly potent, selective NaV1.7 inhibitor, DS-1971a, has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led to the discovery of novel series of cycloalkane derivatives with high NaV1.7 inhibitory pot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6dfbfcf9264e87757e4b9e81ee00d139
https://doi.org/10.1021/acs.jmedchem.0c00259
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6
A voltage-dependent chloride channel from Tetrahymena ciliary membrane incorporated into planar lipid bilayers
Autor: Yutaka Kirino, Chie Fujiwara-Hirashima, Mihoko Takahashi, Kazunori Anzai
Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1280(2):207-216
Membrane vesicles from cilia of Tetrahymena thermophila were incorporated into a planar phospholipid bilayer membrane, and single-channel currents across the planar membrane were recorded under voltage-clamp conditions. A novel and reproducible chlor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1473084893bf1df34acf80c6df63e7
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7
A synthetic peptide corresponding to 86–93 of the human type I IL-1 receptor binds human recombinant IL-1 (α and β) and inhibits IL-1 actions in vitro and in vivo
Autor: Chie Fujiwara, Chiyuki Abe, Masao Tanihara, Etsuko Abe, Tatsuo Suda, Yutaka Mizushima, Suzuki Yasuo
Publikováno v: Biochemical and Biophysical Research Communications. 188:912-920
A synthetic peptide corresponding to 86-93 of the human type I IL-1 receptor and its analogues bound human recombinant (hr) IL-1 (alpha and beta) and inhibited dose-dependently both Con A-stimulated proliferation of mouse spleen cells and hrIL-1 beta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68adb29645b1a9354a96a90140f6c822
https://doi.org/10.1016/0006-291x(92)91142-d
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8
A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation
Autor: Noriaki Shimizu, Hiroyasu Utiyama, Naoko Mochizuki, Chie Fujiwara, Junji Sagara, Tsukasa Oda, Mitsue ohta
Publikováno v: Journal of biochemistry. 111(2)
ETR103 cDNA was cloned as an immediate early gene in the course of macrophagic differentiation of HL-60 cells stimulated by TPA (12-O-tetradecanoylphorbol-13-acetate). The induction by TPA was immediate-early (within 30 min) and transient. This gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6709f477462ab2908e1784c9316a027e
https://pubmed.ncbi.nlm.nih.gov/1569051
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9
Cation Channels from Ciliary Membrane of Tetrahymena Reconstituted into Planar Lipid Bilayer. Comparison between the Channels from the Wild T. Thermophila and from Its Mutant Which Does Not Show Ciliary Reversal1
Autor: Mihoko Takahashi, Yutaka Kirino, Seiji Nagao, Yoshinori Nozawa, Chie Fujiwara, Kazunori Anzai
Publikováno v: The Journal of Biochemistry. 104:344-348
Cation channels in ciliary membrane vesicles from wild type Tetrahymena thermophila and from its mutant which does not show ciliary reversal or avoiding reaction were reconstituted into a planar lipid bilayer. Since the mutant does not produce the re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a87df20126cdedd329c89b201ad7135
https://doi.org/10.1093/oxfordjournals.jbchem.a122471
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