Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Chie, Takemi"'
Autor:
Daisuke Tsuzuki, Chie Takemi, Sumio Shinoda, Shizuo Narimatsu, Tetsuo Satoh, Hiroyuki Kataoka, Kazuo Asaoka, Hiroyuki Hichiya, Shigeo Yamamoto, Satoshi Suzuki
Publikováno v:
Biochemical Pharmacology. 64:1101-1110
A cDNA was cloned from Japanese monkey liver mRNA by reverse transcriptase–polymerase chain reaction (RT–PCR) using oligonucleotide primers based on the marmoset cytochrome P450 2D19 (CYP2D19) nucleotide sequence. The full-length cDNA encoded a 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3186b73524cb005d35ee8f2e9820ac4b
https://doi.org/10.1016/s0006-2952(02)01287-x
https://doi.org/10.1016/s0006-2952(02)01287-x
Autor:
Susumu Imaoka, Chie Takemi, Shizuo Narimatsu, Sumio Shinoda, Yoshihiko Funae, Hiroyuki Kataoka, Shigeo Yamamoto, Daisuke Tsuzuki, Keietsu Tamagake
Publikováno v:
Pharmacogenetics. 11:709-718
A single amino acid-substituted mutant protein, CYP2D6 (G42R) was expressed in Saccharomyces cerevisiae and its enzymatic properties were compared with those of other single (P34S, R296C and S486T) and double amino acid-substituted mutant proteins (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798beb5fa41a375ed378ffe3ec1d3251
https://doi.org/10.1097/00008571-200111000-00010
https://doi.org/10.1097/00008571-200111000-00010
Autor:
Chie Takemi, Hiroyuki Hichiya, Daisuke Tsuzuki, Keietsu Tamagake, Shino Kuramoto, Shigeo Yamamoto, Shizuo Narimatsu
Publikováno v:
Chirality. 15(4)
Bufuralol (BF), a nonselective beta-adrenoceptor blocking agent, has a chiral center in its molecule, yielding the enantiomers 1'R-BF and 1'S-BF. beta-Adrenoceptor blocking potency is much higher in 1'S-BF than in 1'R-BF. One of the metabolic pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1aef22eeae8c3fb1e08b6323274bae
https://pubmed.ncbi.nlm.nih.gov/12666241
https://pubmed.ncbi.nlm.nih.gov/12666241
Autor:
Chie Takemi, Urs A. Meyer, Noriaki Shimada, Daisuke Tsuzuki, Shigeo Yamamoto, Shizuo Narimatsu, Satoshi Suzuki, Frank J. Gonzalez, Tetsuo Satoh, Hiroyuki Kataoka
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 303(1)
A new HPLC method was developed using a chiral column to efficiently separate four 1"-hydroxybufuralol (1"-OH-BF) diastereomers that are major metabolites of bufuralol (BF). Employing this method, we examined diastereomer selectivity in the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306c5955f9bc8073c95b53134f5dea3e
https://pubmed.ncbi.nlm.nih.gov/12235248
https://pubmed.ncbi.nlm.nih.gov/12235248
Autor:
Y. Suzuki, Shigeo Yamamoto, Toyoko Hiroi, Chie Takemi, Hiroyuki Kataoka, Susumu Imaoka, Yoshihiko Funae, Daisuke Tsuzuki, Keietsu Tamagake, Shizuo Narimatsu, H. Hashimoto
Publikováno v:
Drug Metabolism and Pharmacokinetics. 15:82-83
To evaluate CYP2D6 mutants as drug-metabolizing enzymes, we expressed four single amino acid-substituted mutants (P34S, G42R, R296C and S486T) and two double amino acid-substituted mutants (P34S/S486T and R296C/S486T) in yeast cells. The profiles of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48e5fd78b9a9cfd0e6460fc3159446ea
https://doi.org/10.2133/dmpk.15.supplement_82
https://doi.org/10.2133/dmpk.15.supplement_82
Autor:
Shizuo, Narimatsu, Chie, Takemi, Daisuke, Tsuzuki, Hiroyuki, Kataoka, Shigeo, Yamamoto, Noriaki, Shimada, Satoshi, Suzuki, Tetsuo, Satoh, A, Meyer Urs, J, Gonzalez Frank
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics; October 2002, Vol. 303 Issue: 1 p172-8, 7p