Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Chidochangu P, Mpamhanga"'
Autor:
Wen Chiy Liew, Kalyan C. Tirupula, Satoru Eguchi, Richard R. Neubig, Nick Holliday, Jean-Philippe Pin, Anthony P. Davenport, Walter G. Thomas, Amy E. Monaghan, Richard V. Benya, Leigh A. Stoddart, Adam J Pawson, Evi Kostenis, Stephen P.H. Alexander, Patrick Vanderheyden, Khuraijam Dhanachandra Singh, Anthony J. Harmar, Robert T. Jensen, Joanna L. Sharman, Tom I. Bonner, Eliot R. Spindel, Laura Storjohann, Sadashiva S. Karnik, Michael Spedding, J F Battey, Chidochangu P. Mpamhanga, Helen E. Benson
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [161], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::095e35ec420e2457dbada605f4c4c736
https://doi.org/10.2218/gtopdb/f16/2021.3
https://doi.org/10.2218/gtopdb/f16/2021.3
Autor:
J F Battey, Sadashiva S. Karnik, Robert T. Jensen, Chidochangu P. Mpamhanga, Wen Chiy Liew, Tom I. Bonner, Laura Storjohann, Eliot R. Spindel, Jean-Philippe Pin, Amy E. Monaghan, Anthony P. Davenport, Stephen P.H. Alexander, Walter G. Thomas, Patrick Vanderheyden, Leigh A. Stoddart, Evi Kostenis, Kalyan C. Tirupula, Anthony J. Harmar, Richard V. Benya, Joanna L. Sharman, Michael Spedding, Satoru Eguchi, Richard R. Neubig, Nick Holliday, Adam J Pawson, Helen E. Benson
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [194], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33f9272ee27f9adb0b5cf656b6b3c130
https://doi.org/10.2218/gtopdb/f16/2019.5
https://doi.org/10.2218/gtopdb/f16/2019.5
Autor:
Michael Spedding, Joanna L. Sharman, Anthony J. Harmar, Chidochangu P. Mpamhanga, Wen Chiy Liew, Jean-Philippe Pin, Walter G. Thomas, Kalyan C. Tirupula, Anthony P. Davenport, Adam J Pawson, Eliot R. Spindel, Leigh A. Stoddart, Evi Kostenis, Richard V. Benya, Patrick Vanderheyden, Tom I. Bonner, Laura Storjohann, Satoru Eguchi, Robert T. Jensen, Richard R. Neubig, Nick Holliday, Stephen P.H. Alexander, Sadashiva S. Karnik, Amy E. Monaghan, J F Battey, Helen E. Benson
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [191], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfea89f5b7467241e262068af2b90122
https://doi.org/10.2218/gtopdb/f16/2019.4
https://doi.org/10.2218/gtopdb/f16/2019.4
Autor:
Iain T. Collie, Julie A. Frearson, Paul G. Wyatt, Laura A. T. Cleghorn, Ruth Brenk, Chidochangu P. Mpamhanga, Roderick G. Walker, Torsten Luksch, Jeremy C. Mottram, Andrew Woodland, Neil R. Norcross, Ian H. Gilbert, Leah S. Torrie
Publikováno v:
Chemmedchem
New drugs are urgently needed for the treatment of tropical parasitic diseases such as leishmaniasis and human African trypanosomiasis (HAT). This work involved a high-throughput screen of a focussed kinase set of ∼3400 compounds to identify potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2202f6601d8578d3a2bae1b2198e8018
https://doi.org/10.1002/cmdc.201100344
https://doi.org/10.1002/cmdc.201100344
Autor:
David A. Robinson, Alan H. Fairlamb, Ian H. Gilbert, Iain T. Collie, Han B. Ong, Julie A. Frearson, Chidochangu P. Mpamhanga, Paul G. Wyatt, Ruth Brenk, Kevin D. Read, Daniel Spinks, Emma Shanks
Publikováno v:
Chemmedchem
Genetic studies indicate that the enzyme pteridine reductase 1 (PTR1) is essential for the survival of the protozoan parasite Trypanosoma brucei. Herein, we describe the development and optimisation of a novel series of PTR1 inhibitors, based on benz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4c491acee852439be6822f1a2c4436
https://doi.org/10.1002/cmdc.201000450
https://doi.org/10.1002/cmdc.201000450
Autor:
David A. Robinson, Alan H. Fairlamb, Laste Stojanovski, Helen P. Price, Olawale G. Raimi, Michael R. Hodgkinson, M. Lucia S. Güther, Laura A. T. Cleghorn, Ruth Brenk, James A. Brannigan, Chidochangu P. Mpamhanga, Leah S. Torrie, Daan M. F. van Aalten, Paul G. Wyatt, Michael A. J. Ferguson, Anthony J. Wilkinson, Stuart P. McElroy, Ondrej Smid, Stephen Brand, Kevin D. Read, Raymond Hui, Wei Qiu, Julie A. Frearson, Irene Hallyburton, Ian H. Gilbert, Deborah F. Smith
Publikováno v:
Nature
African sleeping sickness or human African trypanosomiasis, caused by Trypanosoma brucei spp., is responsible for approximately 30,000 deaths each year. Available treatments for this disease are poor, with unacceptable efficacy and safety profiles, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd82f45690f4d286a7da2fb6fd9f8b40
http://europepmc.org/articles/PMC2917743
http://europepmc.org/articles/PMC2917743
Autor:
David A. Robinson, William N. Hunter, Emma Shanks, Alan H. Fairlamb, Ian H. Gilbert, Daniel Spinks, Iain T. Collie, Chidochangu P. Mpamhanga, Lindsay B. Tulloch, Paul G. Wyatt, Julie A. Frearson, Ruth Brenk
Publikováno v:
Journal of Medicinal Chemistry
The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual screening campaign for fragments inhibiting PTR1 was carried out. Two novel chemical series were identified containing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255720e57c1d46d64c446b46a179286a
http://europepmc.org/articles/PMC2966039
http://europepmc.org/articles/PMC2966039
Autor:
I. Cozzani, Pietro Giorgio Tiscar, Beining Chen, Dario Compagnone, Chidochangu P. Mpamhanga, M. Del Carlo, Marcello Mascini
Publikováno v:
Analytical Letters. 39:1627-1642
We describe a set of label‐free piezoelectric biosensors for fast, qualitative, and direct detection of HSP 70 in crude extract of the mussel mantle. A monoclonal anti‐HSP 70 antibody and three heptapeptides chosen using a computational/combinato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d442b9cea050392c9f5087a3b89e79f7
https://doi.org/10.1080/00032710600713529
https://doi.org/10.1080/00032710600713529
Autor:
Chidochangu P. Mpamhanga, Tom I. Bonner, Wen Chiy Liew, Jean-Philippe Pin, Anthony P. Davenport, Helen E. Benson, Anthony J. Harmar, Adam J. Pawson, Michael Spedding, Richard R. Neubig, Joanna L. Sharman, Stephen P.H. Alexander, Amy E. Monaghan
Publikováno v:
Davenport, A P, Alexander, S P H, Sharman, J L, Pawson, A J, Benson, H E, Monaghan, A E, Liew, W C, Mpamhanga, C P, Bonner, T I, Neubig, R R, Pin, J P, Spedding, M & Harmar, A J 2013, ' International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list : recommendations for new pairings with cognate ligands ', Pharmacological reviews, vol. 65, no. 3, pp. 967-86 . https://doi.org/10.1124/pr.112.007179
In 2005, the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of the human gene sequences known or predicted to encode G protein-coupled receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f2c78da59cca081ceb8adeac92af38
https://www.pure.ed.ac.uk/ws/files/10297308/International_Union_of_Basic_and_Clinical_Pharmacology._LXXXVIII._G_protein_coupled_receptor_list.pdf
https://www.pure.ed.ac.uk/ws/files/10297308/International_Union_of_Basic_and_Clinical_Pharmacology._LXXXVIII._G_protein_coupled_receptor_list.pdf
Autor:
Adam J. Pawson, Anthony J. Harmar, Anthony P. Davenport, Helen E. Benson, Nc-Iuphar, Veny Lukito, Vincent Bombail, Michael Spedding, Joanna L. Sharman, John A. Peters, Chidochangu P. Mpamhanga
Publikováno v:
Nucleic Acids Research Database issue (41), D1083-1088. (2013)
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2013, 41 (Database issue), pp.D1083-1088. ⟨10.1093/nar/gks960⟩
Sharman, J L, Benson, H E, Pawson, A J, Lukito, V, Mpamhanga, C P, Bombail, V, Davenport, A P, Peters, J A & Spedding, M & Harmar, A J 2013, ' IUPHAR-DB: updated database content and new features ', Nucleic Acids Research, vol. 41, no. D1, pp. D1083-D1088 . https://doi.org/10.1093/nar/gks960
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2013, 41 (Database issue), pp.D1083-1088. ⟨10.1093/nar/gks960⟩
Sharman, J L, Benson, H E, Pawson, A J, Lukito, V, Mpamhanga, C P, Bombail, V, Davenport, A P, Peters, J A & Spedding, M & Harmar, A J 2013, ' IUPHAR-DB: updated database content and new features ', Nucleic Acids Research, vol. 41, no. D1, pp. D1083-D1088 . https://doi.org/10.1093/nar/gks960
International audience; The International Union of Basic and Clinical Pharmacology (IUPHAR) database, IUPHAR-DB (http://www.iuphar-db.org) is an open access, online database providing detailed, expert-driven annotation of the primary literature on hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449192ad1361ea1e547becae80bee35e
http://prodinra.inra.fr/record/328028
http://prodinra.inra.fr/record/328028