Výsledky vyhledávání - "Chidiebere U."

Akademický článek

Exploration of semi-carbazone derivatives as promising agents against cholera: Insights from spectroscopic analysis, reactivity studies (ELF, HOMO-LUMO, NBO), solvation effects, and molecular docking investigations

Autor: Aniekan E. Owen, Isaac A. Anyambula, Chioma U. Benson, Folasade O. Ojumola, John A. Alawa, Innocent Benjamin, Solomon O. Iyam, Chidiebere U. Ogar, Mmefone A. Ojong, Rejoice Ojong, Ejike R. Okafor, Hitler Louis

Publikováno v: Chemical Physics Impact, Vol 8, Iss , Pp 100438- (2024)

This study is aimed at evaluating the impact of solvation on the structural, spectroscopy (UV, NMR, FT-IR), reactivity, bonding interactions, and the drug potential of Pyridine 4-Carbaldehyde Semi-carbazone (PCS) against the disease (cholera) causing

Externí odkaz: https://doaj.org/article/0a3339fcc9af43c284321e8cee1b406c

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Akademický článek

Nanocage-incorporated engineered destabilized 3'UTR ARE of ERBB2 inhibits tumor growth and liver and lung metastasis in EGFR T790M osimertinib- and trastuzumab-resistant and ERBB2-expressing NSCLC via the reduction of ERBB2

Autor: Chidiebere U. Awah, Joo Sun Mun, Aloka Paragodaarachchi, Baris Boylu, Martin Nzegwu, Hiroshi Matsui, Olorunseun Ogunwobi

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

Non-small cell lung cancer (NSCLC) caused more deaths in 2017 than breast cancer, prostate, and brain cancers combined. This is primarily due to their aggressive metastatic nature, leading to more fatal rates of cancer patients. Despite this conditio

Externí odkaz: https://doaj.org/article/d0be878fbec7454e8fe5d7d025ee83e3

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Akademický článek

Genome-scale CRISPR Cas9a knockout screen reveals genes that control glioblastoma susceptibility to the alkylating agent temozolomide

Autor: Chidiebere U. Awah, Jan Winter, Olorunseun O. Ogunwobi

Publikováno v: All Life, Vol 15, Iss 1, Pp 88-93 (2022)

Glioblastoma is the most fatal of all primary human brain tumors, with a 14-month median survival. The mainstay therapy for this tumor involves temozolomide, surgery, radiotherapy, and tumor-treating electric field. Cancer resistance to commonly avai

Externí odkaz: https://doaj.org/article/971edc64f2c945ada4efd9545c0baf71

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Akademický článek

Destabilized 3’UTR elements therapeutically degrade ERBB2 mRNA in drug-resistant ERBB2+ cancer models

Autor: Chidiebere U. Awah, Yana Glemaud, Fayola Levine, Kiseok Yang, Afrin Ansary, Fu Dong, Leonard Ash, Junfei Zhang, Olorunseun O. Ogunwobi

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

Breast, lung, and colorectal cancer resistance to molecular targeted therapy is a major challenge that unfavorably impacts clinical outcomes leading to hundreds of thousands of deaths annually. In ERBB2+ cancers regardless of the tissue of origin, ma

Externí odkaz: https://doaj.org/article/c0558a24851944ae854a1c8e6f92e72b

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Akademický článek

Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy

Autor: Amol Mehta, Chidiebere U. Awah, Adam M. Sonabend

Publikováno v: Frontiers in Neurology, Vol 9 (2018)

Despite advances in surgery, radiotherapy, and chemotherapy, glioblastoma (GBM) remains a malignancy with poor prognosis. The molecular profile of GBM is diverse across patients, and individual responses to therapy are highly variable. Yet, patients

Externí odkaz: https://doaj.org/article/3dee0bb578ed44af90a3ab5dee530c6e

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