Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Chichung Chan"'
Autor:
Amy Guan, Bo Gao, Ning Li, Chengde Wu, Jian Li, Yongguo Li, Yan Pan, Liang Shen, Miao He, Lei Huang, Jikui Sun, Yu Tao, Chichung Chan, Gong Zhen, Hongyu Yuan, Li Yi, Zhengang Peng, Li Jie, Xiulian Lu, Chen Shuhui, Dongling Hao
Publikováno v:
ACS Medicinal Chemistry Letters. 9:256-261
[Image: see text] The identification and lead optimization of a series of pyridopyrimidinone derivatives are described as a novel class of efficacious dual PI3K/mTOR inhibitors, resulting in the discovery of 31. Compound 31 exhibited high enzyme acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b3dbc008661a0a0c9ac0473178d68b
https://doi.org/10.1021/acsmedchemlett.8b00002
https://doi.org/10.1021/acsmedchemlett.8b00002
Autor:
Jian Lin, Chichung Chan, Chengde Wu, Chunli Shen, Shuhua Han, Xin Li, Tingting Guo, Shuhui Chen, Qiang Xiao, Lu Huang, Hailiang Chen, Ronghua Tu, Yong Xu, Xuehai Wang
Publikováno v:
The Journal of Immunology. 196:210.15-210.15
Bruton’s Tyrosine Kinase (BTK) plays a crucial role in B cell differentiation and proliferation, making it an attractive target to treat inflammatory and autoimmune diseases. A small molecule BTK inhibitor, WX486, showed a high potency and selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::588d6e2a87343c437061fcb16824bc59
https://doi.org/10.4049/jimmunol.196.supp.210.15
https://doi.org/10.4049/jimmunol.196.supp.210.15