Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Chichi Huang"'
Autor:
Yuqi Wang, Quan Quan, Camille Gleason, Helin Yu, Lujia Peng, Yanshen Kang, Ling Jiang, Kailun Wu, Jie Pan, Moxiyele Bao, Qing Zhu, Meiqi Yi, Ming Fang, Yue Zheng, Ling Qiu, Bin Xu, Xiang Li, Jinfeng Song, Jiamu Sun, Zheng Zhang, Zijun Su, Jara Lin, Yuanyuan Xie, April Xu, Xiling Song, Chichi Huang, Zhirong Shen, Lai Wang, Jing Song
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTPharmaceutical companies have recently focused on accelerating the timeline for initiating first-in-human (FIH) trials to allow quick assessment of biologic drugs. For example, a stable cell pool can be used to produce materials for the toxic
Externí odkaz:
https://doaj.org/article/ba17fb85493c4f9899ea329c80eb8296
Autor:
Meiqi Yi, Jian Sun, Hanzi Sun, Yifei Wang, Shan Hou, Beibei Jiang, Yuanyuan Xie, Ruyue Ji, Liu Xue, Xiao Ding, Xiaomin Song, April Xu, Chichi Huang, Quan Quan, Jing Song
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAspartic acid (Asp) isomerization is a spontaneous non-enzymatic post-translation modification causing a change in the structure of the protein backbone, which is commonly observed in therapeutic antibodies during manufacturing and storage. T
Externí odkaz:
https://doaj.org/article/491684443e3b468c8519952468d40754
Autor:
Lauren E. Boucher, Elisabeth Geyer Prinslow, Michael Feldkamp, Fang Yi, Rupesh Nanjunda, Sheng-Jiun Wu, Tun Liu, Eilyn R. Lacy, Steven Jacobs, Natalia Kozlyuk, Brian Del Rosario, Bingyuan Wu, Patricia Aquino, Robert C. Davidson, Samantha Heyne, Nicholas Mazzanti, James Testa, Michael D. Diem, Elsa Gorre, Andrew Mahan, Hirsh Nanda, Harsha P. Gunawardena, Alexis Gervais, Anthony A. Armstrong, Alexey Teplyakov, Chichi Huang, Adam Zwolak, Partha Chowdhury, Wan Cheung Cheung, Jinquan Luo
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTSingle-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric antigen receptor T cells or natural killer cells. However, scFv domains exhibit lo
Externí odkaz:
https://doaj.org/article/07a49e5767d741f0bc24b50e3af689e1
Autor:
Chen-Ni Chin, Thai Dinh, Michael J. Hunter, Serena M. Nelson, Jose Antonio Chavez, Stephen C Beck, Anthony A. Armstrong, Jennifer L. Furman, Cassandre R. Cavanaugh, Shamina M. Rangwala, Chichi Huang, Tanesha Cash-Mason, Xiefan Lin-Schmidt, Victoria J South, Shannon E. Mullican
Publikováno v:
Nature Medicine. 23:1150-1157
Growth differentiation factor 15 (GDF15), a distant member of the transforming growth factor (TGF)-β family, is a secreted protein that circulates as a 25-kDa dimer. In humans, elevated GDF15 correlates with weight loss, and the administration of GD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e19bc608fabd84931b74c1f4df934a4
https://doi.org/10.1038/nm.4392
https://doi.org/10.1038/nm.4392
Autor:
Chichi Huang, Andrew Miller, Mindi Walker, Denise Chroscinski, Ram Achuthanandam, Thomas Nesspor, Peter J. Bugelski, Dorie Makropoulos, Kerry Brosnan, Justin Avery, Devon D. Egenolf, Krista Wilson
Publikováno v:
Current Pharmaceutical Biotechnology
CNTO 530 is an erythropoietin receptor agonist MIMETIBODYTM construct. CNTO 530 has been shown to be active in a number of rodent models of acquired anemia (e.g. renal insufficiency and chemotherapy induced anemia). We investigated the efficacy of CN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6e0ddd4abbea364d75bbd218fbbb2c
https://doi.org/10.2174/1389201011314020015
https://doi.org/10.2174/1389201011314020015
Autor:
Jerry Lee, Michael P. Maher, Judith Ann Connor, Lu Lu, Elena Garcia, Chichi Huang, Hong Zhou, Yi Liu, Wai-Ping Fung-Leung, Nancy Wu, Karen Ngo, Brian Scott, Ross Fellows, Alan D. Wickenden, Wilson Edwards, Ronald V. Swanson, Ellen Chi, Rachelle Bonesteel
Publikováno v:
The Journal of biological chemistry. 289(33)
Ion channels are an attractive class of drug targets, but progress in developing inhibitors for therapeutic use has been limited largely due to challenges in identifying subtype selective small molecules. Animal venoms provide an alternative source o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9782a1925c7d3d97c492daaaefaf5517
https://pubmed.ncbi.nlm.nih.gov/24939846
https://pubmed.ncbi.nlm.nih.gov/24939846
Publikováno v:
Journal of Biological Chemistry. 275:22202-22212
We find that monoclonal antibody YTA-1 recognizes an epitope formed by a combination of the integrin alpha(L) and beta(2) subunits of LFA-1. Using human/mouse chimeras of the alpha(L) and beta(2) subunits, we determined that YTA-1 binds to the predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8c6b8dad2d9bfc4ce8633969034846
https://doi.org/10.1074/jbc.m002883200
https://doi.org/10.1074/jbc.m002883200
Publikováno v:
Journal of Biological Chemistry. 275:21514-21524
To establish a structure and function map of the β2 integrin subunit, we mapped the epitopes of a panel of β2 monoclonal antibodies including function-blocking, nonblocking, and activating antibodies using human/mouse β2 subunit chimeras. Activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1516a53c9388c04ec9d148dfd006e6f7
https://doi.org/10.1074/jbc.m002286200
https://doi.org/10.1074/jbc.m002286200
Publikováno v:
Proceedings of the National Academy of Sciences. 94:3156-3161
We have used immunoprecipitation with mAbs to probe folding during biosynthesis of the β2integrin subunit of lymphocyte function-associated antigen 1 (LFA-1; CD11a/CD18) before and after association with the αLsubunit. An evolutionarily conserved r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e66f1a27f82802495291d4cfd66e767
https://doi.org/10.1073/pnas.94.7.3156
https://doi.org/10.1073/pnas.94.7.3156
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1088
The MIMETIBODY™ platform was developed to expand the opportunities for application of biotherapeutics. While the utility of antibodies as antagonists has been well demonstrated, their application as agonists has been more challenging. For steric re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::299a46488d19f32cfe8c9697c45f87f9
https://pubmed.ncbi.nlm.nih.gov/24146401
https://pubmed.ncbi.nlm.nih.gov/24146401