Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.

Autor: Hinklin RJ; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States. Electronic address: rhinklin@arraybiopharma.com., Baer BR; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Boyd SA; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Chicarelli MD; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Condroski KR; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., DeWolf WE Jr; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Fischer J; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Frank M; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Hingorani GP; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Lee PA; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Neitzel NA; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Pratt SA; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Singh A; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Sullivan FX; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Turner T; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Voegtli WC; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Wallace EM; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Williams L; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States., Aicher TD; Array BioPharma Inc., 3200 Walnut St., Boulder, CO 80301, United States.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Jan 01; Vol. 28 (1), pp. 115232. Date of Electronic Publication: 2019 Dec 02.