Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Chibuzor Olelewe"'
Autor:
R. Tyler Mertens, Jong Hyun Kim, Samuel Ofori, Chibuzor Olelewe, Paul J. Kamitsuka, Gunnar F. Kwakye, Samuel G. Awuah
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116010- (2024)
Triple-negative breast cancer (TNBC) is associated with metabolic heterogeneity and poor prognosis with limited treatment options. New treatment paradigms for TNBC remains an unmet need. Thus, therapeutics that target metabolism are particularly attr
Externí odkaz:
https://doaj.org/article/7b0052f6d7a84bc88ec1ced1acc9d4e4
Autor:
Chibuzor Olelewe, Jong Hyun Kim, Samuel Ofori, Randall T. Mertens, Sailajah Gukathasan, Samuel G. Awuah
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104340- (2022)
Summary: Chemical agents that specifically exploit metabolic vulnerabilities of cancer cells will be beneficial but are rare. The role of oxidative phosphorylation (OXPHOS) in promoting and maintaining triple-negative breast cancer (TNBC) growth prov
Externí odkaz:
https://doaj.org/article/352aa5f49ee648eda75194e12d86adcc
Autor:
R. Tyler Mertens, Sailajah Gukathasan, Adedamola S. Arojojoye, Chibuzor Olelewe, Samuel G. Awuah
Publikováno v:
Chemical Reviews. 123:6612-6667
Publikováno v:
Chemical Communications. 58:10237-10240
Emerging synthetic development of chiral gold(iii) complexes has prompted new opportunities in catalysis and material science with limited utility in biomedicine.
Autor:
Chibuzor Olelewe, Samuel G. Awuah
Publikováno v:
Current Opinion in Chemical Biology. 72:102235
In pursuit of better treatment options for malignant tumors, metal-based complexes continue to show promise as attractive chemotherapeutics due to tunability, novel mechanisms, and potency exemplified by platinum agents. The metabolic character of tu