Výsledky vyhledávání - "Chiayung Chu"

The Vi Conjugate Typhoid Vaccine Is Safe, Elicits Protective Levels of IgG Anti-Vi, and Is Compatible with Routine Infant Vaccines

Autor: Feng-Ying C. Lin, Shousun C. Szu, John B. Robbins, Rachel Schneerson, Vu Dinh Thiem, Steven Hunt, Nguyen Hong Son, Do Gia Canh, Nguyen Duc Mao, Chiayung Chu, Dang Duc Anh

Publikováno v: Clinical and Vaccine Immunology. 18:730-735

Typhoid fever remains a serious problem in developing countries. Current vaccines are licensed for individuals who are 5 years old or older. A conjugate of the capsular polysaccharide (CP) of Salmonella enterica serovar Typhi (Vi) bound to recombinan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c386a9c164cb89be73713e29d1996a5
https://doi.org/10.1128/cvi.00532-10

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O-Acetylation in the O-specific polysaccharide isolated from Shigella flexneri serotype 2a

Autor: Chiayung Chu, Joanna Kubler-Kielb, Evgeny Vinogradov, Rachel Schneerson

Publikováno v: Carbohydrate Research. 342:643-647

Shigella flexneri causes diarrheal diseases especially in infants and children in developing countries. Modifications of the lipopolysaccharide (LPS) molecule, like bacteriophage-mediated glucosylation and acetylation of the O-specific chain (O-SP),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d95f668b57c929bfc97ea98340e6b7c
https://doi.org/10.1016/j.carres.2006.09.017

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Treatment with Succinic Anhydride Improves the Immunogenicity of Shigella flexneri Type 2a O-Specific Polysaccharide–Protein Conjugates in Mice

Autor: Nathaniel W. Tolson, Danka Pavliakova, Slavomir Bystricky, Chiayung Chu, John B. Robbins, Joseph Shiloach, Dolores A. Bryla, Rachel Schneerson, Jeanne B. Kaufman

Publikováno v: Infection and Immunity. 67:5526-5529

Seroepidemiological data and a clinical trial with a Shigella sonnei O-specific polysaccharide (O-SP)– Pseudomonas aeruginosa recombinant exoprotein A ( r EPA) conjugate provide evidence that a critical level of immunoglobulin G (IgG) lipopolysacch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3972bbca8f6238936f34d44ea1e6639
https://doi.org/10.1128/iai.67.10.5526-5529.1999

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Protein conjugates of synthetic saccharides elicit higher levels of serum IgG lipopolysaccharide antibodies in mice than do those of the O-specific polysaccharide fromShigella dysenteriaetype 1

Autor: Vince Pozsgay, John B. Robbins, Chiayung Chu, Lewis K. Pannell, Jennifer Wolfe, Rachel Schneerson

Publikováno v: Proceedings of the National Academy of Sciences. 96:5194-5197

Our development of vaccines to prevent shigellosis is based on the hypothesis that a critical (protective) level of serum IgG to the O-specific polysaccharide (O-SP) domain ofShigellalipopolysaccharide (LPS) confers immunity. The O-SP is a hapten and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2214ada92d1913ad855e07459751b8ba
https://doi.org/10.1073/pnas.96.9.5194

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Phase I clinical trial of O-acetylated pectin conjugate, a plant polysaccharide based typhoid vaccine

Autor: Nguyen Duc Thinh, Shousun C. Szu, Steven Hunt, Kimi Lin, Chiayung Chu

Publikováno v: Vaccine. 32(22)

Typhoid fever remains an important cause of morbidity and mortality in the developing countries. Vi capsular polysaccharide conjugate vaccine demonstrated safety and efficacy in young children in high endemic regions. A novel typhoid conjugate vaccin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5144a94889f92d861a844f8d9829575b
https://pubmed.ncbi.nlm.nih.gov/24657719

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Phase 1 Study of a Recombinant Mutant Protective Antigen of Bacillus anthracis

Autor: Rachel Schneerson, Feng-Ying C. Lin, German A. Benavides, Joseph Shiloach, Chunyan Guo, Mahtab Moayeri, Joseph A. Bellanti, Stephen H. Leppla, Chiayung Chu, John B. Robbins, Arthur B. Karpas

A phase 1 study of a recombinant mutant protective antigen (rPA) vaccine was conducted in 186 healthy adults aged 18 to 45 years. Volunteers were randomized to receive one of three formulations of rPA (formalin treated, alum adsorbed, or both), in 10

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https://europepmc.org/articles/PMC3272932/

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Autor: Justen H. Passwell, Joseph Shiloach, Shai Ashkenzi, Hadas Even-Nir, Nahid Farzam, Rachel Schneerson, Yonit Banet-Levi, Liat Lerner-Geva, Chiayung Chu, John B. Robbins, Reut Ramon-Saraf, Baruch Yerushalmi

Publikováno v: Vaccine. 28(10)

Background Despite its high worldwide morbidity and mortality, there is yet no licensed vaccine for shigellosis. We reported the safety and immunogenicity of Shigella O-specific polysaccharide–protein conjugates in adults and young children and eff

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https://pubmed.ncbi.nlm.nih.gov/31378536

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Preparation, characterization, and immunogenicity of conjugates composed of the O-specific polysaccharide of Shigella dysenteriae type 1 (Shiga's bacillus) bound to tetanus toxoid

Autor: Joseph Shiloach, Chiayung Chu, Rachel Schneerson, S S Szu, JohnB Robbins, Dolores A. Bryla, B K Liu, Douglas Watson

Publikováno v: Infection and Immunity. 59:4450-4458

The background for developing conjugate vaccines for shigellosis composed of the O-specific polysaccharide (O-SP) bound to a protein is described elsewhere (C. Y. Chu, R. Schneerson, and J. B. Robbins, submitted for publication). Briefly, there is di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffb0eb56d75ad381bc3fea6d0694f9a
https://doi.org/10.1128/iai.59.12.4450-4458.1991

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