Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Chiatogu Onyewu"'
1
Neck and Waist Circumference Biomarkers of Cardiovascular Risk in a Cohort of Predominantly African-American College Students: A Preliminary Study
Autor: Catherine J. Klein, Eric P. Hoffman, Chiatogu Onyewu, Maria Eugenia Hurtado, Amy Schweitzer, Heather J. Hoffman, Thaddeus J. Arnold
Publikováno v: Journal of the Academy of Nutrition and Dietetics. 114:107-116
Receiver operating characteristic curves were constructed to assess the value of measuring neck and waist circumference and waist-to-hip ratio (WHR) as biomarkers of metabolic syndrome in college students (18 to 25 years of age). Participants (n=109)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64180e3648770188a73a633dfbe90ba5
https://doi.org/10.1016/j.jand.2013.07.005
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2
Targeting the Calcineurin Pathway Enhances Ergosterol Biosynthesis Inhibitors against Trichophyton mentagrophytes In Vitro and in a Human Skin Infection Model
Autor: Emily Eads, Chiatogu Onyewu, Yehuda Ullmann, Benjamin A. Horwitz, Wiley A. Schell, Israela Berdicevsky, Gil Kaufman, John R. Perfect, Joseph Heitman
Publikováno v: Antimicrobial Agents and Chemotherapy. 51:3743-3746
Fluconazole-FK506 or fluconazole-cyclosporine drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by scanning electron microscopy over a 7-day treatment period. The fl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0615e5dc0d25ba5c67ae2c67ac08596e
https://doi.org/10.1128/aac.00492-07
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4
The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicans
Autor: Chiatogu Onyewu, John R. Perfect, Floyd L. Wormley, Joseph Heitman
Publikováno v: Infection and Immunity. 72:7330-7333
In Candida albicans , calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae . However, the in vitro phenotypes of C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ef4f11b766b88a0850d82053174ef1
https://doi.org/10.1128/iai.72.12.7330-7333.2004
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5
In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus
Autor: Chiatogu Onyewu, John R. Perfect, Wiley A. Schell, William J. Steinbach, Joseph Heitman, Jill R. Blankenship
Publikováno v: Antimicrobial Agents and Chemotherapy. 48:1664-1669
The optimal treatment for invasive aspergillosis remains elusive, despite the increased efficacy of newer agents. The immunosuppressants cyclosporine (CY), tacrolimus (FK506), and sirolimus (formerly called rapamycin) exhibit in vitro and in vivo act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7230c276caab70bea5a5a80c92860f
https://doi.org/10.1128/aac.48.5.1664-1669.2004
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6
Ergosterol Biosynthesis Inhibitors Become Fungicidal when Combined with Calcineurin Inhibitors against Candida albicans , Candida glabrata , and Candida krusei
Autor: Chiatogu Onyewu, Joseph Heitman, Jill R. Blankenship, Maurizio Del Poeta
Publikováno v: Antimicrobial Agents and Chemotherapy. 47:956-964
Azoles target the ergosterol biosynthetic enzyme lanosterol 14α-demethylase and are a widely applied class of antifungal agents because of their broad therapeutic window, wide spectrum of activity, and low toxicity. Unfortunately, azoles are general
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a20bfc23b978b7567386ec2a74f3a5
https://doi.org/10.1128/aac.47.3.956-964.2003
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7
Calcineurin Promotes Infection of the Cornea by Candida albicans and Can Be Targeted To Enhance Fluconazole Therapy
Autor: Natalie A. Afshari, Chiatogu Onyewu, Joseph Heitman
Publikováno v: Antimicrobial Agents and Chemotherapy. 50:3963-3965
In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ece639628888e67f6752b43e331169
https://doi.org/10.1128/aac.00393-06
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8
Effect of the SORT1 low-density lipoprotein cholesterol locus is sex-specific in a fit, Canadian young-adult population
Autor: Angela E. Karlos, Gina M. Many, Jane Shearer, Eric P. Hoffman, Dustin S. Hittel, Chiatogu Onyewu, Elizabeth Gnatiuk
Publikováno v: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 38(2)
The SORT1 locus was originally identified by genome-wide association studies of low-density lipoprotein cholesterol (LDL-C) in adults. Although the effect sizes of this locus are relatively small, we hypothesized that a younger population would show
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b15cc49db39d2564c61049292596c10
https://pubmed.ncbi.nlm.nih.gov/23438231
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