Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Chiara Zurzolo"'
Autor:
Roberto Notario Manzano, Thibault Chaze, Eric Rubinstein, Esthel Penard, Mariette Matondo, Chiara Zurzolo, Christel Brou
Publikováno v:
eLife, Vol 13 (2024)
Tunneling nanotubes (TNTs) are open actin- and membrane-based channels, connecting remote cells and allowing direct transfer of cellular material (e.g. vesicles, mRNAs, protein aggregates) from the cytoplasm to the cytoplasm. Although they are import
Externí odkaz:
https://doaj.org/article/6f310202fe5e423d9eeabde9031a6014
Autor:
Stéphanie Lebreton, Simona Paladino, Mickaël Lelek, Marc Tramier, Christophe Zimmer, Chiara Zurzolo
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The spatiotemporal compartmentalization of membrane-associated glycosylphosphatidylinositol-anchored proteins (GPI-APs) on the cell surface regulates their biological activities. These GPI-APs occupy distinct cellular functions such as enzymes, recep
Externí odkaz:
https://doaj.org/article/9fa0b161e643413bbf6e4506620c1af9
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-12 (2023)
Abstract Tunnelling Nanotubes (TNTs) facilitate contact-mediated intercellular communication over long distances. Material transfer via TNTs can range from ions and intracellular organelles to protein aggregates and pathogens. Prion-like toxic protei
Externí odkaz:
https://doaj.org/article/30b17a8cf2c048d692577a0c2a5b2580
Autor:
Patricia Chastagner, Frida Loria, Jessica Y Vargas, Josh Tois, Marc I Diamond, George Okafo, Christel Brou, Chiara Zurzolo
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 12, Pp 1-20 (2020)
Abstract Tau accumulation in the form of neurofibrillary tangles in the brain is a hallmark of tauopathies such as Alzheimer's disease (AD). Tau aggregates accumulate in brain regions in a defined spatiotemporal pattern and may induce the aggregation
Externí odkaz:
https://doaj.org/article/ac1f9fb33cb0485ebf048cfa49feb9f0
Publikováno v:
Cell Stress, Vol 4, Iss 2, Pp 30-43 (2020)
Intercellular communication is a fundamental property of multicellular organisms, necessary for their adequate responses to changing environment. Tunneling nanotubes (TNTs) represent a novel means of intercellular communication being a long cell-to-c
Externí odkaz:
https://doaj.org/article/38e9dc302e1e4c859b22805c0d195c8d
Autor:
Aysegul Dilsizoglu Senol, Maura Samarani, Sylvie Syan, Carlos M Guardia, Takashi Nonaka, Nalan Liv, Patricia Latour-Lambert, Masato Hasegawa, Judith Klumperman, Juan S Bonifacino, Chiara Zurzolo
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001287 (2021)
The accumulation of α-synuclein (α-syn) aggregates in specific brain regions is a hallmark of synucleinopathies including Parkinson disease (PD). α-Syn aggregates propagate in a "prion-like" manner and can be transferred inside lysosomes to recipi
Externí odkaz:
https://doaj.org/article/8d3afd767fd24d5ca05e43b7ded91e8a
Autor:
Anna Sartori-Rupp, Diégo Cordero Cervantes, Anna Pepe, Karine Gousset, Elise Delage, Simon Corroyer-Dulmont, Christine Schmitt, Jacomina Krijnse-Locker, Chiara Zurzolo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The architecture of functional TNTs is still under debate. Here, the authors combine correlative FIB-SEM, light- and cryo-electron microscopy approaches to elucidate the structure of TNTs in neuronal cells, showing that they form structures that are
Externí odkaz:
https://doaj.org/article/662b3487f2bf4b0b9737c82c133296c0
Autor:
Clara Grudina, Georgia Kouroupi, Takashi Nonaka, Masato Hasegawa, Rebecca Matsas, Chiara Zurzolo
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Parkinson's disease (PD) is the second most common neurodegenerative disorder whereby loss of midbrain dopaminergic neurons results in motor dysfunction. Transplantation of human induced pluripotent stem cells (iPSCs) into the brain of patients affec
Externí odkaz:
https://doaj.org/article/b5429555a6b94eadb2f0edc6d765e084
Autor:
Anna Pepe, Rosario Avolio, Danilo Swann Matassa, Franca Esposito, Lucio Nitsch, Chiara Zurzolo, Simona Paladino, Daniela Sarnataro
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Shadoo (Sho), a member of prion protein family, has been shown to prevent embryonic lethality in Prnp 0/0 mice and to be reduced in the brains of rodents with terminal prion diseases. Sho can also affect PrP structural dynamics and can incre
Externí odkaz:
https://doaj.org/article/1a4316d3a77d4fc7be9465ba7d6814ea
Autor:
Jennifer Ariazi, Andrew Benowitz, Vern De Biasi, Monique L. Den Boer, Stephanie Cherqui, Haifeng Cui, Nathalie Douillet, Eliseo A. Eugenin, David Favre, Spencer Goodman, Karine Gousset, Dorit Hanein, David I. Israel, Shunsuke Kimura, Robert B. Kirkpatrick, Nastaran Kuhn, Claire Jeong, Emil Lou, Robbie Mailliard, Stephen Maio, George Okafo, Matthias Osswald, Jennifer Pasquier, Roel Polak, Gabriele Pradel, Bob de Rooij, Peter Schaeffer, Vytenis A. Skeberdis, Ian F. Smith, Ahmad Tanveer, Niels Volkmann, Zhenhua Wu, Chiara Zurzolo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and
Externí odkaz:
https://doaj.org/article/b2e205f432ef419f9ebd1c6bb3338615